1XP9,1XB7,2PJL,1KV6,2PJL,1YY4


Conserved Protein Domain Family
NR_LBD_ER_like

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cd07068: NR_LBD_ER_like 
Click on image for an interactive view with Cn3D
The ligand binding domain of estrogen receptor and estrogen receptor-related receptors
The ligand binding domain of estrogen receptor (ER) and estrogen receptor-related receptors (ERRs): Estrogen receptors are a group of receptors which are activated by the hormone estrogen. Estrogen regulates many physiological processes including reproduction, bone integrity, cardiovascular health, and behavior. The main mechanism of action of the estrogen receptor is as a transcription factor by binding to the estrogen response element of target genes upon activation by estrogen and then recruiting coactivator proteins which are responsible for the transcription of target genes. Additionally some ERs may associate with other membrane proteins and can be rapidly activated by exposure of cells to estrogen. ERRs are closely related to the estrogen receptor (ER) family. But, it lacks the ability to bind estrogen. ERRs can interfere with the classic ER-mediated estrogen signaling pathway, positively or negatively. ERRs share target genes, co-regulators and promoters with the estrogen receptor (ER) family. Like other members of the nuclear receptor (NR) superfamily of ligand-activated transcription factors, ER and ERRs have a central well conserved DNA binding domain (DBD), a variable N-terminal domain, a non-conserved hinge and a C-terminal ligand binding domain (LBD).
Statistics
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PSSM-Id: 132753
View PSSM: cd07068
Aligned: 21 rows
Threshold Bit Score: 262.158
Threshold Setting Gi: 74935853
Created: 30-Jan-2009
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 18 residues -Click on image for an interactive view with Cn3D
Feature 1:ligand binding site [chemical binding site]
Evidence:
  • Structure:1XP9_a; human estrogen receptor alpha binds to a Dihydrobenzoxathiin, molecule 18, contacts at 4A
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                          ## ### ##  
1XP9_A      9 MVSALLDAE-PPILYSEYdptrp-------------------------------------fseaSMMGLLTNLADRELVH 50  human
Q8WS79    237 ILEVLNSYE-PDALSVQTpppqvhttsitndeassssgsiklessvvtpngtcifqnnnnndpnEILSVLSDIYDKELVS 315 fruit fly
XP_392385 223 MLEALAACE-PDMLQVSNishtl-------------------------------------dtdqRVLGQLSDLYDRELVG 264 honey bee
EEB18499  226 ILEALSLNE-PDISVMAQdisna-------------------------------------dpavRTLNILSDLYDQELVK 267 human body louse
Q6VU64    202 ILEALQKADlPVMDSYHNhnlp--------------------------------------atrvHLLNTLIKLADRELVY 243 California sea hare
1YY4_A      6 LVLTLLEAE-PPHVLISRpsap--------------------------------------fteaSMMMSLTKLADKELVH 46  human
ACB10649  308 LISHLVNIE-PNPILTGYnpqct-------------------------------------ptegYLMALVTDLANREIEG 349 Florida lancelet
Q7ZU32    285 LISRIMEAE-PPEIYLMKdmkkp-------------------------------------fteaNVMMSLTNLADKELVH 326 zebrafish
P06212    309 MVSALLEAE-PPIVYSEYdpnrp-------------------------------------fneaSMMTLLTNLADRELVH 350 chicken
P81559    307 LISALMEAE-APIVYSEHdstkp-------------------------------------lseaSMMTLLTNLADRELVH 348 African clawed frog
Feature 1                               #   ##     #          #                   #           
1XP9_A     51 MINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPG-KLLFAPNLLLDrnqgkcvegmvEIFDMLLATSSRF 129 human
Q8WS79    316 VIGWAKQIPGFIDLPLNDQMKLLQVSWAEILTLQLTFRSLPFNG-KLCFATDVWMDehlak-ecgytEFYYHCVQIAQRM 393 fruit fly
XP_392385 265 IIGWAKQIPGFSSLALNDQMRLLQSTWAEILTFSLAWRSMPNNG-RLRFAQDFTLDerlar-echctELYTHCIQIVERL 342 honey bee
EEB18499  268 IITWAKHIPGFLDLTLNDQMRLLQSTWAEILTLTVTYRSLPGTG-ELKFAADFSFDekmar-ecgamDIYQHCMHIVERQ 345 human body louse
Q6VU64    244 LINWAKHVPGYTCLTLGDQVHLIECCWMELLLLNCAFRSMEHEGrTLVFAPDFHLErqqwa-ltgmgDVLEQVSAVSEQM 322 California sea hare
1YY4_A     47 MISWAKKIPGFVELSLFDQVRLLESCWMEVLMMGLMWRSIDHPG-KLIFAPDLVLDrdegkcvegilEIFDMLLATTSRF 125 human
ACB10649  350 LVDWAARLPGYGMLPMDDQVNLIRTVWLDLLMLGLVWRSMEHRGeWLVFAPDLLMDrslcr-lsgmeYICTPMLEFARQF 428 Florida lancelet
Q7ZU32    327 MISWAKKIPGFVELSLFDQVHLLECCWLEVLMLGLMWRSVNHPG-KLIFSPDLCLSrdesscvqglvEIFDMLLAATSRF 405 zebrafish
P06212    351 MINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPG-KLLFAPNLLLDrnqgkcvegmvEIFDMLLATAARF 429 chicken
P81559    349 MINWAKRVPGFVDLTLHDQVHLLECAWLEILMVGLIWRSVEHPG-KLSFAPNLLLDrnqgrcveglvEIFDMLVTTATRF 427 African clawed frog
Feature 1                                                                                     
1XP9_A    130 RmMNLQGEEFVCLKSIILLNSGVYtflsstlksleEKDHIHRVLDKITDTLIHLMAkagltlqqqhqRLAQLLLILSHIR 209 human
Q8WS79    394 ErISPRREEYYLLKALLLANCDILl---------dDQSSLRAFRDTILNSLNDVVYllrhs--savsHQQQLLLLLPSLR 462 fruit fly
XP_392385 343 QrLGLTREEYYVLKALILANSDARs---------dEPQALYRFRDSILNSLSDCMAavrpg--qalrATQNMFLVLPSLR 411 honey bee
EEB18499  346 EkLNITKEEYYIIKALVLANSDVRi---------dDLPPLKKLRDNILSALADCVAvlrpn--ttslHMNHLLLCLPALR 414 human body louse
Q6VU64    323 LlHGLNKEELLLLQATVLVNAEVRpl--------dSFLKIQEMRQLILDVFMEVAGrhqgf--gnwrHAPSILLLLTHIR 392 California sea hare
1YY4_A    126 ReLKLQHKEYLCVKAMILLNSSMYplvta-tqdadSSRKLAHLLNAVTDALVWVIAksgissqqqsmRLANLLMLLSHVR 204 human
ACB10649  429 AdLQVPQEVYVCLKALTLYTTAVSrl--------qDYRQVQRLQHEINEALAEACSstfg---fspgNIARLMMIVSQVR 497 Florida lancelet
Q7ZU32    406 ReLKLQREEYVCLKAMILLNSNMClgsseggedlqSRSKLLCLLDSVTDALVWAISktglsfqqrstRLAHLLMLLSHIR 485 zebrafish
P06212    430 RmMNLQGEEFVCLKSIILLNSGVYtflsstlksleERDYIHRVLDKITDTLIHLMAksglslqqqhrRLAQLLLILSHIR 509 chicken
P81559    428 RmMRLRGEEFICLKSIILLNSGVYtflsstlesleDTDLIHIILDKIIDTLVHFMAksglslqqqqrRLAQLLLILSHIR 507 African clawed frog
Feature 1          #  ##     #    #          
1XP9_A    210 HMSNKGMEHLysMKCKNVVPLYDLLLEMLDA 240 human
Q8WS79    463 QADDILRRFWrgIARDEVITMKKLFLEMLEP 493 fruit fly
XP_392385 412 QVDGIVRRFWssVYRTGKVPMNKLFVEMLEA 442 honey bee
EEB18499  415 QADYINRRFWtaVHREGKVYMNKLFIEMLES 445 human body louse
Q6VU64    393 QAGERGITYFqkLKMEGCVTFCDLLTEMLDA 423 California sea hare
1YY4_A    205 HASNKGMEHLlnMKCKNVVPVYDLLLEMLNA 235 human
ACB10649  498 QLSSLGVDHLnrLRGAETVSVEGLLREIVDE 528 Florida lancelet
Q7ZU32    486 HVSNKGMDHLhcMKMKKMVPLYDLLLEMLDA 516 zebrafish
P06212    510 HMSNKGMEHLynMKCKNVVPLYDLLLEMLDA 540 chicken
P81559    508 HMSNKGMEHLysMKCKNVVPLYDLLLEMLDA 538 African clawed frog

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