1T8P,1E59,1FZT,1K6M,1RII,1UJB,1XQ9,1YFK,2A6P,2AXN,2P6O,2QNI,2RFL,3D8H,3DCY,3E9C,3EOZ,3EZN,3F2I,3F3K,3PGM,2F90,2IKQ,1H2E


Conserved Protein Domain Family
HP_PGM_like

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cd07067: HP_PGM_like 
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Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction.
Subgroup of the catalytic domain of a functionally diverse set of proteins, most of which are phosphatases. The conserved catalytic core of this domain contains a His residue which is phosphorylated in the reaction. This subgroup contains cofactor-dependent and cofactor-independent phosphoglycerate mutases (dPGM, and BPGM respectively), fructose-2,6-bisphosphatase (F26BP)ase, Sts-1, SixA, and related proteins. Functions include roles in metabolism, signaling, or regulation, for example, F26BPase affects glycolysis and gluconeogenesis through controlling the concentration of F26BP; BPGM controls the concentration of 2,3-BPG (the main allosteric effector of hemoglobin in human blood cells); human Sts-1 is a T-cell regulator; Escherichia coli Six A participates in the ArcB-dependent His-to-Asp phosphorelay signaling system. Deficiency and mutation in many of the human members result in disease, for example erythrocyte BPGM deficiency is a disease associated with a decrease in the concentration of 2,3-BPG.
Statistics
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PSSM-Id: 132718
View PSSM: cd07067
Aligned: 310 rows
Threshold Bit Score: 47.702
Threshold Setting Gi: 75544137
Created: 8-Jan-2008
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
catalytic core
Conserved site includes 5 residues -Click on image for an interactive view with Cn3D
Feature 1:catalytic core [active site]
Evidence:
  • Comment:The catalytic core includes a His group which is phosphorylated during phosphoryl transfer as well as two key Arg residues and an additional His residue which are hydrogen bonded to the phospho group before, during, and after transfer.
  • Structure:1H2E_A, Bacillus stearothermophilus PhoE bound with phosphate ion, contacts calculated at 3.5A.
    View structure with Cn3D
  • Structure:2IKQ_A, Mus musculus Sts-1 (Suppressor of T- Cell Receptor) phosphatase domain bound with phosphate ion, contacts calculated at 3.5A.
    View structure with Cn3D
  • Structure:1E59_A, Escherichia coli bound with a tungstate ion (a phosphate analog), contacts calculated at 3.5 A.
    View structure with Cn3D
  • Structure:2F90_A, human bisphosphoglycerate mutase homodimer bound with 3-phosphoglycerate and Alf4-, contacts calculated at 3.5 A.
    View structure with Cn3D
  • Comment:Alf4- mimics the intermediate in phosphoryl transfer reactions.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1          ##                                                     #                   
1T8P_A      5 KLIMLRHGEGAwnkenr-fcswvDQKLNSEGMEEARNCGKQLkaln--fefdLVFTSVLNRSIHTAWLILeelgqewvPV 81  human
1H2E_A      3 TLYLTRHGETKwnverr-mqgwqDSPLTEKGRQDAMRLGKRLeav----elaAIYTSTSGRALETAEIVRggr---liPI 74  Geobacillus stearo...
Q6M6A8     20 VVLLIRHGQTPttgqvl-pgqtpGLHLSDKGEEQAREVAQRLaev----pitAVYSSPMERAQETAAPTVsah---glEL 91  Corynebacterium gl...
Q9ZAX0      2 KLYLVRHGQTAsnvakkldtalpGPPLTELGHEQARQLAEKLate----pveAVYASHATRAQQTAAPLAqal---gmTV 74  Amycolatopsis meth...
Q745R9      2 QVLLVRHALPLrseh----gqgsDPDLSADGLAQIERLPKALerf----pisRVVSSPQRRAVQTAAPVAadr---glSV 70  Mycobacterium aviu...
Q9A6W6      3 IVHVIRHGRPAstwg----gadeDPGLDEFGLAQARAVADEIlslpeherpsRVVSSPLRRCRETAAPLAeal---gvAL 75  Caulobacter vibrio...
Q9F3Q7      2 RLLLIRHGQTPsnlkhlldtaepGPGLTALGQEQAAALPGALase----eigALYASTLVRTQLTAAPLAsat---glEV 74  Streptomyces coeli...
Q73U87     36 TVTFVRHAQSEanasgtidtevpGPGLSPEGKGQAEQVAHQLgrk----dydSVYASTMTRAQQTAAPLAael---gkQV 108 Mycobacterium aviu...
O06240      2 TVILLRHARSTsntagv-lagrsGVDLDEKGREQATGLIDRIgdl----pirAVASSPMLRCQRTVEPLAeal---clEP 73  Mycobacterium tube...
Q87UC2      3 HVRLIRHGESAanagqp-svdhaTIPLTLKGVEQAQSVARSFtha-----paLIVASPFSRAQATAMATVstf---paTP 73  Pseudomonas syring...
Feature 1                                                                                     
1T8P_A     82 ESSWRLNErhygaliglnreqmalnhgeeqvrlwrrsynvtpppieeshpyyqeiyndrrykvcdvpldqlprseslkdv 161 human
1H2E_A     75 YQDERLREihlgdwegkthdeirqmdpiaf-----------------------------dhfwqaphlyapqrgerfcdv 125 Geobacillus stearo...
Q6M6A8     92 TVEPGLIEcdfgewtgrkltelnaleewk-------------------------------avqktpstfrfpggesfvem 140 Corynebacterium gl...
Q9ZAX0     75 KRVEGVHEivvgdlegrhdreaiehyltvl-----------------------------shwtrgelhvpmpggetgeqa 125 Amycolatopsis meth...
Q745R9     71 EIDDRFAEydrdlpvyipveqirdempe---------------------------------ewarlaqghlpsavdedaf 117 Mycobacterium aviu...
Q9A6W6     76 VIDPRVGEiptpaalsaeerpawlra-------------------------------------afggrwdeivgdidytk 118 Caulobacter vibrio...
Q9F3Q7     75 RVRAGIREltagdlemrgdddaartymhta-----------------------------fawsagdvglrmpggengaea 125 Streptomyces coeli...
Q73U87    109 EVLPGIQEinagwyngksesmakstylvap-----------------------------anwlkgdvsdsipgsisgkef 159 Mycobacterium aviu...
O06240     74 LIDDRFSEvdygewtgrkigdlvdeplwr-------------------------------vvqahpsaavfpggeglaqv 122 Mycobacterium tube...
Q87UC2     74 FETWPIQEftyleparctnttvaqrrgwvea----------------------------ywarsdpaftegagaesflef 125 Pseudomonas syring...
Feature 1                                  ##                                                 
1T8P_A    162 lERLLPYWNERiapev---lrgkTILISAHGNSSRALLKHLegisdedi-initlptgVPILLElden-------lraVG 230 human
1H2E_A    126 qQRALEAVQSIvdrh-----egeTVLIVTHGVVLKTLMAAFkdtpldhlwsppymygtSVTIIEvdg--------gtfHV 192 Geobacillus stearo...
Q6M6A8    141 qDRMVEAIGNIaqqh-----pgeIVAAFSHADTIKAAVAHFvgtpldsf-qrifidtaSISAVEftgkss---gvsshML 211 Corynebacterium gl...
Q9ZAX0    126 rARFTGAIAGLaerhdl-trsdgVVVLVSHGGLIRIGAEWLapnvrpeladqglipntGIVELEia----------adGG 194 Amycolatopsis meth...
Q745R9    118 rARVRAAVDDLvaaa----dpedTVAVFSHGGVINVLLHEIlgtarll---sfpvdyaSVTRLLfsrsgqatvaavnsTE 190 Mycobacterium aviu...
Q9A6W6    119 wTRAVAAALGEh----------gGAAVFSHFVALNGAVSAAtgrpevm---afrpdhcSRTVFGie-----------dDR 174 Caulobacter vibrio...
Q9F3Q7    126 lARFDAVVAEAhet------gaeTVALVSHGAAIRMWVAARadnvdvdyaerhplantGIVILSgs----------pgQG 189 Streptomyces coeli...
Q73U87    160 nDQFTAAVNKIyns------ghrNPVVFSHANSIMVWTLMNtrnakdslmnthplpntGRVVINgn----------piTG 223 Mycobacterium aviu...
O06240    123 qTRAVAAVREHdrrladqhghdvLWLACTHGDVIKAVIADAfgmhldsf-qritadpgSVSVVRytql-------rpfVL 194 Mycobacterium tube...
Q87UC2    126 iARAQSLLVRLaeh------paqYIAVFSHGQFINAVAWLIertpqri----dgramaDWREYEi-------------TN 182 Pseudomonas syring...
Feature 1          
1T8P_A    231 pHQFL 235 human
1H2E_A    193 aVEGD 197 Geobacillus stearothermophilus
Q6M6A8    212 -LTNS 215 Corynebacterium glutamicum
Q9ZAX0    195 -WQCL 198 Amycolatopsis methanolica
Q745R9    191 -HVWD 194 Mycobacterium avium subsp. paratuberculosis
Q9A6W6    175 -LILI 178 Caulobacter vibrioides
Q9F3Q7    190 -WRAL 193 Streptomyces coelicolor
Q73U87    224 -WTLV 227 Mycobacterium avium subsp. paratuberculosis
O06240    195 -HVNH 198 Mycobacterium tuberculosis
Q87UC2    183 -PVPN 186 Pseudomonas syringae pv. tomato

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