1IJX,1IJY


Conserved Protein Domain Family
CRD_FZ

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cd07066: CRD_FZ 
Click on image for an interactive view with Cn3D
CRD_domain cysteine-rich domain, also known as Fz (frizzled) domain
CRD_FZ is an essential component of a number of cell surface receptors, which are involved in multiple signal transduction pathways, particularly in modulating the activity of the Wnt proteins, which play a fundamental role in the early development of metazoans. CRD is also found in secreted frizzled related proteins (SFRPs), which lack the transmembrane segment found in the frizzled protein. The CRD domain is also present in the alpha-1 chain of mouse type XVIII collagen, in carboxypeptidase Z, several receptor tyrosine kinases, and the mosaic transmembrane serine protease corin. The CRD domain is well conserved in metazoans - 10 frizzled proteins have been identified in mammals, 4 in Drosophila and 3 in Caenorhabditis elegans. CRD domains have also been identified in multiple tandem copies in a Dictyostelium discoideum protein. Very little is known about the mechanism by which CRD domains interact with their ligands. The domain contains 10 conserved cysteines.
Statistics
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PSSM-Id: 143549
View PSSM: cd07066
Aligned: 133 rows
Threshold Bit Score: 45.9607
Threshold Setting Gi: 66820580
Created: 30-Sep-2008
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
putative Wnt
Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1:putative Wnt binding site [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                       # ##         ###                                                  
1IJX_A          4 ACEPVRi------pLCKSl-------pWEMTKMPNhlhhs-------------tqanAILAMEQfe-----------glL 46   house mouse
XP_646545      51 TCSNYIgdsi-dqpLCNEklpn--yknIYTSKNITiqyi--------------nqkiVEKTFISlt------------fL 101  Dictyostelium...
XP_636810      34 ECLNYIgdpi-dqqLCNSklqn-ngdrIYTTTNSQids----------------qtnIKKSFEAit------------fL 83   Dictyostelium...
XP_002131027   37 ECELINl------pRCGKl-------qSGFISLPNpfghwtqleivnssnykfleraSEVLMTQaesvhseeasnvtfeD 103  Ciona intesti...
XP_643987      36 KCLSFIgdsn-nqqLCNNklin-kqliYSTINKSNqiqs---------------lkmVEQSFKQlt------------fL 86   Dictyostelium...
XP_636816      34 QCMNYIgdsi-dqpLCKNklsnngefiYSTIGNSLnsqtl-------------sqqtIAKSFEAlt------------fI 87   Dictyostelium...
XP_646349      30 KCEILNpi-----sMCSNyl------gYKNIYLPYgytq--------------eiieANVTATLtnpmg------fsaiP 78   Dictyostelium...
XP_643884      31 KCEKYIgdgdsgkrICNGylan--pdsVYVHNKTQq--------------------eTLKDLRSlinll------elnnP 82   Dictyostelium...
XP_638502      35 KCEPYIgds--qitKCSTfl-----pnINSIYVSAns-------------------tQKDSMKTldnyfg----lllavG 84   Dictyostelium...
XP_638470      29 KCEQYIgds--vitPCNSiy------vSSTANQSTam------------------lsLNLYFSLlg------------gS 70   Dictyostelium...
Feature 1                                                                                         
1IJX_A         47 GTHCSPd--LLFFLCAMYAPICTidfq--------hepiKPCKSVCErarqgCEPILIkyrhs----------------- 99   house mouse
XP_646545     102 QSKCFDlnfAEFGICDIYFPPCFqtpttitpiksvslpqRLCKSACErmvsnCSSLGAslncsdplkfpriatly----n 177  Dictyostelium...
XP_636810      84 QDQCKDllfAQFGICDIYLAPCIevtltpl--ksislpqRFCKSVCDrmvsnCPRLEEqmdcsnsflfpeigtfy----d 157  Dictyostelium...
XP_002131027  104 FQRCEQq--IHQLTCAVIAPKCFflsrl------svssvPPCKRVCVevrerCSDLLIsgglq----------------- 158  Ciona intesti...
XP_643987      87 QGKCLNlnfAQFGICDIYFPSCVetsfg------islpkRLCKSVCKqivtdCPTLGVslncsdsnkfptigtly----n 156  Dictyostelium...
XP_636816      88 QNQCQDllfAEYGICNIYLSPCIittvapl--knislpqRLCNSACQrmvtnCPRLGEkidcsisflfpevgtly----n 161  Dictyostelium...
XP_646349      79 DLICKEn--IIKLFCISTYRECNsningi----sfplpsNPCQKNCFkvletCVPFLSffq------------------- 133  Dictyostelium...
XP_643884      83 SKECINp-sNYKIMCAMMFPECIeingtniv-kpitlpiYTCNSFCKealvtCSVPNTiascdggtnlpiqlpytpiewv 160  Dictyostelium...
XP_638502      85 SEKCKDsslTYQTLCSMYLKECEsftdnstl-ktvsipkRICRKTCNdvtklCNIESLfncsqne--------------- 148  Dictyostelium...
XP_638470      71 SASCQNa-yTFATLCSTYLPECEifidnstn-keiampkRVCLDTCNsvsknCQITSYfdcnqlepisklplfpke--ss 146  Dictyostelium...
Feature 1                                                                
1IJX_A        100 ----------wpeslACDELPvyd----------------------rgvCISPEA 122  house mouse
XP_646545     178 ltdygftanggffpvPCSDPLatfenkst-------------tselieiCPSPLL 219  Dictyostelium discoideum AX4
XP_636810     158 lspygytidngtfavPCSDPTiffnqvss-------------nssfieiCPSPLL 199  Dictyostelium discoideum AX4
XP_002131027  159 ----------wpvflDCQEFIecdi---------------------etvCRGRRS 182  Ciona intestinalis
XP_643987     157 ltkygytenngfyqvECSNPTnyyyneins-----------tnnqfieiCPSPLV 200  Dictyostelium discoideum AX4
XP_636816     162 lsdygykangglyevPCFNPTadydnsss-------------lnefieiCPSPLL 203  Dictyostelium discoideum AX4
XP_646349     134 -------------gfSCQQNDtdgkdlypitenyynltsyggssnqsiqCSNPNQ 175  Dictyostelium discoideum AX4
XP_643884     161 kynltiyggvddyrvNCTDPTlisdsgs--------------sseievgCVEPLI 201  Dictyostelium discoideum AX4
XP_638502     149 ---------pinnlpLCPLNYsiydlslvn-----------gdsnyelqCYSPLS 183  Dictyostelium discoideum AX4
XP_638470     147 dynlttyggelnyrlDCYDPPksnet------------------tvigyCPFPLV 183  Dictyostelium discoideum AX4

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