3CGI


Conserved Protein Domain Family
BMC_PduU-EutS

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cd07046: BMC_PduU-EutS 
Click on image for an interactive view with Cn3D
1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain
PduU encapsulates several related enzymes within a shell composed of a few thousand protein subunits. PduU exists as a hexamer which might further assemble into the flat facets of the polyhedral outer shell of the pdu organelle. This proteinaceous noncarboxysome microcompartment is involved in coenzyme B12-dependent degradation of 1,2-propanediol. The core of PduU is related to the typical BMC domain and its natural oligomeric state is a cyclic hexamer. Unlike other typical BMC domain proteins, the 3D topology of PduU reveals a circular permuted variation on the typical BMC fold which leads to several unique features. The exact functions related to those unique features are still not clear. Another difference is the presence of a deep cavity on one side of the hexamer as well as an intermolecular six-stranded beta barrel that seems to block the central pore that is present in other BMC domain proteins. EutS proteins included in this CD are sequence homologs of PduU. They are encoded within eut operon and may be required for the formation of the outer shell of bacterial eut polyhedral organelles which are involved in the cobalamin-dependent degradation of ethanolamine. Although it has been suggested that EutS might also form hexamers and play similar functional roles in the construction of the eut organelle outer shell at present no experimental evidence directly supports this view.
Statistics
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PSSM-Id: 132886
View PSSM: cd07046
Aligned: 19 rows
Threshold Bit Score: 159.341
Threshold Setting Gi: 212696378
Created: 7-Oct-2002
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
putativeputative
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:putative hexamer interface [polypeptide binding site]
Evidence:
  • Comment:Based on Synechocystis sp. CcmK2 (2A1B) and CcmK4 (2A10)

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                          #  #        #  ##     #    # #
3CGI_A         8 DRMIQEYVPGKQVTLAHLIANPGKDLFKKLGLQDAv--------sAIGILTITPSEASIIACDIATKSGAVEIGFLDRFT 79  Salmonella typh...
ABC25524       5 QRIIQELVPGKQITLAHIIANPDPILYQKLGLNPAvey----akaAIGVLTVSPAETAIIMADIGIKSAGVELGFVDRFS 80  Roseburia inuli...
ZP_01723369    6 KRFIQEFVPGKQLTLSHLIANPDPEMFQKLGIQESg---------ALGIMTCTPSETVIIAGDLATKAANVRLGFLDRFT 76  Bacillus sp. B1...
ZP_01962309   27 LRLTRVRVPGKSLDFAHVITPSDPAVYQNLALNIGvhegedhtgeSIGIMRVTPWEAIVVATDVAVKAADVQVGFMDRFS 106 Ruminococcus ob...
ZP_01962310    9 IRIVQETVAGKEITFAHVMGGPAPIIYQKLGLNPQvdy----rssAIGIMNMTPSESAVIASDIAVKSGNVYLGFADRFT 84  Ruminococcus ob...
YP_001396790  13 VRIIQETVPGKQITIAHIIASPDDIIYKKLGLNPTidy----gkaAIGIVCMSPSETAIITGDIASKAANIDIGFVDRFS 88  Clostridium klu...
ZP_02038426   27 LRIVRVKVIGRAISLAQLIGVSDRRIYENLGLHIGthqgedhtgeSIGLLHITPWEATVAAADIAMKSGDVELGFLDRFS 106 Bacteroides cap...
YP_001558293   7 LRIVQELVPGKQISLAHIIAAPDPLLMEKLCFQKEner----mkaAIGILTMSPAETVIIGADLALKASGVTLQNVDYAS 82  Clostridium phy...
ZP_02089656   14 MRIIQESVPGKQITMAHIIASPDEVIYKKLGLDPKvdy----hrsAIGVLTLTPSETAIITADLAIKASNIQIGFIDRFS 89  Clostridium bol...
YP_001663552   5 QRIIQEYVPGKQITLAHIIASPQIELCEKLGIEKKe---------AIGIMTITPAEGAIIAADIALKTSTVKIGFLDRFS 75  Thermoanaerobac...
Feature 1                                             
3CGI_A        80 GAVVLTGDVSAVEYALKQVTRTLgemMQFTTCsITRT 116 Salmonella typhimurium
ABC25524      81 GSVIVTGTVSEVEASIQAILQYVentLGYAVTpVTRT 117 Roseburia inulinivorans
ZP_01723369   77 GSLVIVGSVSEVEMAMLEINRFLsevLGYTPSrITKS 113 Bacillus sp. B14905
ZP_01962309  107 GALIILGGLSQVMTAVEEVVKFFrdeLHFDVCeIHKS 143 Ruminococcus obeum ATCC 29174
ZP_01962310   85 GTMIITGEISDVMSAMTEVVDYFrdtLGYVVCnITKR 121 Ruminococcus obeum ATCC 29174
YP_001396790  89 GTLIITGGVAEVESAMKAVANYCrdkLFFTVCeITRT 125 Clostridium kluyveri DSM 555
ZP_02038426  107 GAVILLGNRAEVKSALEAVLTYFreeLHFSVCdLTER 143 Bacteroides capillosus ATCC 29799
YP_001558293  83 GTLVFTGTVSEVEAAMNAVVEYSnrtLSFTVCdITRT 119 Clostridium phytofermentans ISDg
ZP_02089656   90 GTLIITGTISDVNIAFERILEYTsseLDFTVCrITKA 126 Clostridium bolteae ATCC BAA-613
YP_001663552  76 GSLVIIGNISAVDEAIHRIMNTLvrvLNFSPCpITKS 112 Thermoanaerobacter sp. X514

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