2G13,2A10,2A1B


Conserved Protein Domain Family
BMC_CcmK_like

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cd07045: BMC_CcmK_like 
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Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain
Bacterial micro-compartments are primitive protein-based organelles that sequester specific metabolic pathways in bacterial cells. The prototypical bacterial microcompartment is the carboxysome shell, a bacterial polyhedral organelle which increase the efficiency of CO2 fixation by encapsulating RuBisCO and carbonic anhydrase. They can be divided into two types: alpha-type carboxysomes (alpha-cyanobacteria and proteobacteria) and beta-type carboxysomes (beta-cyanobacteria). Potential functional differences between the two types are not yet fully understood. In addition to these proteins there are several homologous shell proteins including those found in pdu organelles involved in coenzyme B12-dependent degradation of 1,2-propanediol and eut organelles involved in the cobalamin-dependent degradation of ethanolamine. Structure evidence shows that several carboxysome shell proteins and their homologs (Csos1A, CcmK1,2,4, and PduU) exist as hexamers which might further assemble into extended, tightly packed layers hypothesized to represent the flat facets of the polyhedral organelles outer shell. Although it has been suggested that other homologous proteins in this family might also form hexamers and play similar functional roles in the construction of their corresponding organelle outer shells at present no experimental evidence directly supports this view.
Statistics
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PSSM-Id: 132885
View PSSM: cd07045
Aligned: 32 rows
Threshold Bit Score: 54.0861
Threshold Setting Gi: 193215581
Created: 7-Oct-2002
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 17 residues -Click on image for an interactive view with Cn3D
Feature 1:Hexamer interface [polypeptide binding site]
Evidence:
  • Structure:2A10; Synechocystis sp. CcmK4 forms a hexamer; contacts defined at 3.5A.
    View structure with Cn3D
  • Structure:2A1B; Synechocystis sp. CcmK2 forms a hexamer; contacts defined at 3.5A.
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1             #  #        #  ##     #    #   ###                                ### # ## 
2G13_A         8 ALGMIETRGlVPAIEAADAMTKAAeVRLVGRQFv-gGGYVTVLVRGETGAVNAAVRAGADACerv-gdGLVAAHIIARVh 85  Halothiobacillu...
2A10_A         6 AVGSIETIGfPGILAAADAMVKAGrITIVGYIRa-gSARFTLNIRGDVQEVKTAMAAGIDAInrtegaDVKTWVIIPRPh 84  Synechocystis sp.
2A1B_A         4 AVGMIETRGfPAVVEAADSMVKAArVTLVGYEKi-gSGRVTVIVRGDVSGVQASVSAGIEAAnrvnggEVLSTHIIARPh 82  Synechocystis sp.
NP_561819      6 ALGMIETRGlVGAIEAADAMVKAAnVQLVGKEQv-gGGLVTVMVRGDVGAVKAATDAGAAAAer--vgDLISVHVIPRPh 82  Clostridium per...
Q7UVJ9         7 ALGMIETKGfVSAVEATDAMMKAAnVQFLGWDKi-gAGLATVFVTGDVAAVKAATDAGAAAAgr--vgEVVSVQVIPRPh 83  Pirellula sp.
ABD13950       4 ALGMIETKGlVASIEAADQMVKAAnVTLTGQEKi-gSGLVTVMIRGDVGAVKAAVDAGVQAAeg--vgEVVSSYVIPRPh 80  Lactobacillus r...
YP_001511924   5 ALGMIETRSlVAAIEAADTMVKSAdVKIVDLNYv-gSGIISVIVSGEVAAVQAAVSNGTEAVkg--igEIISTNVIPRPh 81  Alkaliphilus or...
YP_001663562   4 AIGLIETVGlVAAIEAADAAVKAAnVKLIGYELargSGLTTVKIKGDVGAVKAAVEAGKAAAlr--vgKVYAVHIIPRPd 81  Thermoanaerobac...
ACJ12449       4 AIGMIETRGyVASLAAADAMVKAAnVTLIGRAEv-gDGLVAVIINGDVGAVKAATEAGSETAat--igELVSVHVIPRPh 80  Rhodococcus sp....
ZP_03304513    7 AIGLIETLGmLPAIKALDAMLKAAdVKLVSYENi-gSTLVTVIVRGDVSSCISAVEAGVAEGek--igKITAHNVMKRPv 83  Anaerococcus hy...
Feature 1         #     
2G13_A        86 SEVENIL 92  Halothiobacillus neapolitanus
2A10_A        85 ENVVAVL 91  Synechocystis sp.
2A1B_A        83 ENLEYVL 89  Synechocystis sp.
NP_561819     83 FEVDAIL 89  Clostridium perfringens str. 13
Q7UVJ9        84 GDLEKIL 90  Pirellula sp.
ABD13950      81 EEVEKIL 87  Lactobacillus reuteri
YP_001511924  82 DEVSKIL 88  Alkaliphilus oremlandii OhILAs
YP_001663562  82 KQVGFIV 88  Thermoanaerobacter sp. X514
ACJ12449      81 ADLAKHF 87  Rhodococcus sp. T104
ZP_03304513   84 TNVSKVI 90  Anaerococcus hydrogenalis DSM 7454

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