1H4X,1AUZ,1TIL,1VC1


Conserved Protein Domain Family
STAS_anti-anti-sigma_factors

?
cd07043: STAS_anti-anti-sigma_factors 
Click on image for an interactive view with Cn3D
Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation
Anti-anti-sigma factors play an important role in the regulation of several sigma factors and their corresponding anti-sigma factors. Upon dephosphorylation they bind the anti-sigma factor and induce the release of the sigma factor from the anti-sigma factor. In a feedback mechanism the anti-anti-sigma factor can be inactivated via phosphorylation by the anti-sigma factor. Well studied examples from Bacillus subtilis are SpoIIAA (regulating sigmaF and sigmaC which play an important role in sporulation) and RsbV (regulating sigmaB involved in the general stress response). The STAS domain is also found in the C- terminal region of sulphate transporters and stressosomes.
Statistics
?
PSSM-Id: 132914
View PSSM: cd07043
Aligned: 472 rows
Threshold Bit Score: 43.2784
Threshold Setting Gi: 24214027
Created: 16-Oct-2008
Updated: 2-Oct-2020
Structure
?
Program:
Drawing:
Aligned Rows:
 
anti sigmaregulatory
Conserved site includes 18 residues -Click on image for an interactive view with Cn3D
Feature 1:anti sigma factor interaction site
Evidence:
  • Structure:1TIL; Geobacillus stearothermophilus SpoIIAA SpoIIAB complex, contacts determined at 4A
    View structure with Cn3D

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1                        # ###     #                       # ### ###  ##                
1H4X_A        3 FQLEMVtreTVVIRLFGELDHHAVEQIRAKISTAIFqgavtTIIWNFERLsFMDXSGVGLVLGRMRELeavagRTILLNP 82  Lysinibacillus s...
1TIL_F        8 IDLEVKq-dVLIVRLSGELDHHTAEELREQVTDVLEnrairHIVLNLGQLtFMDASGLGVILGRYKQIknvggQMVVCAV 86  Geobacillus stea...
YP_394040     6 FKTIYSd-nKLSLKFKGELTLYNLMKYKKEIDKIAFsk-enAVVIDLLELsFLDSAGSIFLNNLQKELelkelKVDITCH 83  Sulfurimonas den...
YP_434335     3 VETKSStdgSVTISIRGQFDFGVVNQFRKAYEAHPQa---rSFCVDMRQTvRIDSSALGMLLNMRLYLggnraKIRIINC 79  Hahella chejuens...
ZP_01165421   6 IFTEQQa-nSVTFSLPHSFTEANYDQLICAVEPFLQgy--eRFVIDLSHTdRIDTVVLGCFLVLKEKIqaskgEVVLLNP 82  Neptuniibacter c...
YP_743246     6 YTARNGk--ELVLEIQGRFDFGLHKPFRRAYRGRAGl---eTYRVDLRQAeSMDSSALGMLLLLREHAsgqgaRVVLRHC 80  Alkalilimnicola ...
YP_864085    13 MIKTWNikgKIHIQLDEPLNAKNQVAFLKAVETHPQg---eQVSLHMDLVpYIDSSGLASLLQLRDHAhg-fhNVILCNP 88  Magnetococcus sp...
YP_864129     4 LHKEVQe-gVVILILEGRFDVSSIETFQEAYADQPPg---tIFKIHLDKVtYIDSAAFGLFHALKQHLgn-lgRVMLYNP 78  Magnetococcus sp...
YP_866001     3 IQQSIDa-eRVVLVLRGDLNHCAHQTFMRVIHSLSPd---tRCTIHLDMVaSIDSAGLGMLLVLFEQLgskpkTVLLCNP 78  Magnetococcus sp...
YP_866966     3 IHTSLNd-nELVISLVGSFSHAIFKEFKNAYLPLTPgp-sfRYCIDLSQVkSLDSSVLGMFLMLRAHAgeaeaDITLRNP 80  Magnetococcus sp...
Feature 1            #   ## #        
1H4X_A       83 SpTMRKVFQFSGLg--PWMMD 101 Lysinibacillus sphaericus
1TIL_F       87 SpAVKRLFDMSGLfkiIRVEA 107 Geobacillus stearothermophilus
YP_394040    84 NrDVLDMLELIRVq-kITLKK 103 Sulfurimonas denitrificans DSM 1251
YP_434335    80 SnEIRKIFEIAKFeksFIIES 100 Hahella chejuensis KCTC 2396
ZP_01165421  83 HgMTMQMLERANFsqlFQVEY 103 Neptuniibacter caesariensis
YP_743246    81 QeEVDEILRTANFqklFEIER 101 Alkalilimnicola ehrlichei MLHE-1
YP_864085    89 SeRVLHTLRVSNFhrlYTIQQ 109 Magnetococcus sp. MC-1
YP_864129    79 SdEVTHAIQVLGAhrsFEIMR 99  Magnetococcus sp. MC-1
YP_866001    79 CrQVAGALRNSNFyalFEIRD 99  Magnetococcus sp. MC-1
YP_866966    81 TnLVLRMLLAARFdtmFKIVT 101 Magnetococcus sp. MC-1

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap