AraC/XylS family transcriptional regulators similar to HpaA, N-terminal cupin domain
Members of this family contain an N-terminal cupin domain and a C-terminal AraC/XylS family helix-turn-helix (HTH) DNA-binding domain, similar to Escherichia coli 4-hydroxyphenylacetate catabolism regulatory protein HpaA (also known as 4HPA). HpaA is encoded by the hpaA gene which is located upstream of hpaBC. It is activated by 4-HPA, 3-HPA and phenylacetate, and represents a member of the AraC/XylS family of regulators that recognizes aromatic effectors. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.
Feature 1: metal binding site [ion binding site], 4 residue positions
Conserved feature residue pattern:H H [HQ] H
Evidence:
Comment:The four-coordinate metallocenter usually includes three histidines and one glutamate; however, this protein may bind metal via different amino acids
Jiyao W et al.(2023). "The conserved domain database in 2023.",