1Y9I,1RFZ,1RFZ,1TLQ


Conserved Protein Domain Family
PgpA

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cd06971: PgpA 
Click on image for an interactive view with Cn3D
Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism
Phosphatidylglycerophosphatase A domain represents a family of bacterial membrane-associated enzymes involved in lipid metabolism. The prototype of this CD is a putative Phosphatidylglycerophosphatase A (PGPase A) from Listeria monocytogenes. PGPase A (EC: 3.1.3.27), encoded by the gene pgpA, specifically catalyzes the formation of phosphatidylglycerol from phosphatidyl glycerophosphate (PGP). It requires Mg2+ for activity and is inhibited by sulfhydryl agents and freezing/thawing. PGPase B encoded from pgpB is not included in this family, which also acts on phosphatidic acid (PA) and lysophosphatidic acid (LPA). Aside from PGPase A and B, evidence shows that there is another PGPase existing in E. coli. Thus, PGPase A is not essential for PGPase activity in E. coli.
Statistics
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PSSM-Id: 133477
View PSSM: cd06971
Aligned: 167 rows
Threshold Bit Score: 67.9483
Threshold Setting Gi: 14590282
Created: 8-Jan-2008
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
binucleartetramer
Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1:binuclear metal-binding site [ion binding site]
Evidence:
  • Structure:1Y9I; Listeria Monocytogenes PGPase with two metal ions, Ca2+ and Mg2+; defined at 3.5A contacts.
    View structure with Cn3D
  • Comment:Each monomer contains a hetero-binuclear center with two metal ions, Ca(2+) and Mg(2+), in its active site.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                        
1Y9I_A        14 ARSWLIERGve-idDIAELVLFLQQKYhpg--lelDICRQNVEHVlrkrevQNAVLTGIQLDVXaekgelvqplQNIISA 90  Listeria monocy...
YP_001273507 228 ILDYFVSEGil-lgDLVEAGLALVAGVevte-eisEKLEAQILKSlcdinvIALLMAAIRTEADftg----griREVDVS 301 Methanobrevibac...
O27183       136 VEELLEARGvt-idGMVDAGMDLVVGVdvta-elrDRLRSEIQRAlgdlnvRALLAAALHLEGDien----lriLGVDLR 209 Methanothermoba...
Q6LWV7        28 VVKLLSNLGvnfdnMLKCGMYMCICDEsdkq-kieTKFLEIMEKQiknpnvSTLLIAAITMDERgrn----gglPFDYDS 102 Methanococcus m...
YP_001325677   5 VIKLLSNYNisidsIINCGMELCICNEdeie-iirKKLERELLKNlsnpnlSTLIIASIKLEEEgkk----gnlPFNYDE 79  Methanococcus a...
NP_142348      5 LLKKLEAKGit-leKMLDAALELYIGGekg--rvrEKLREIMLHYled-vnVQALLTSAILLEE----------NFKVEG 70  Pyrococcus hori...
YP_001046649   4 IERRLEEKGiv-rrDIVAAAMELYVPHgieadeaaRRLDAKIGKAledpniSSLLLGALLLEDElyv----krkDSEIAD 78  Methanoculleus ...
NP_614955    214 IKTILEEEGie-lnDLVEAGRELFVGEwke--ehaSRVLEELERGlenpnvALAVFTALLIDRFvrlgt-ypeeCGELRE 289 Methanopyrus ka...
YP_001056418 187 DAYDLFERAlg-atRREFSQAFAALLKeaplpvkeGEELRELDKFlkdpnvWALILAASELDAMgtrglipglsAEEFKS 265 Pyrobaculum cal...
NP_558565    184 DRYDLFQRIfg-lsRREFAGLVKRLFEkaplpageEEILSALEELlkdpnvWALLIAAAELDAHatsggipglaPDEHSA 262 Pyrobaculum aer...
Feature 1             #  ##                                           #  ##               
1Y9I_A        91 DEGl-YGVDEILALSIVNVY-GSIGFTNYGYIDKV-KPGILAKLnehdgiavHTFLDDIVGAIAAAAASRLAH 160 Listeria monocytogenes
YP_001273507 302 DDPayLYTDEVLGLAISNQIaGTKATFNFKRYDEA-KPGIIGGL--------GPMVDDIFAGLIAGCMSKIFE 365 Methanobrevibacter smi...
O27183       210 DDPafLYSDEVLGMAVANQVaGTKAIFNFKRYDEE-KPGILGEL--------GPMVDDAVAGLIAGCMSRLFE 273 Methanothermobacter th...
Q6LWV7       103 DPTy-VYADEVIGMAIANEIaGTKATFNFKWYDAK-KPGVIGKLdk----egYMFLDDAVAGFVAGCMSKVFE 169 Methanococcus maripaludis
YP_001325677  80 DPNy-IYADEVIGMAIANEIaGTKATFNFKWYDRK-KPGIIGTLde----ngLVFLDDAIAGLIAGCMSKIFE 146 Methanococcus aeolicus...
NP_142348     71 DPVn-LIADELIGIDIAEYIgGKLGLFNFFYYDTK-KPGILSEL--------PPFLDDAIGGFIAGCMSRLFQ 133 Pyrococcus horikoshii OT3
YP_001046649  79 DPVf-LLSDEIIGMAIAEVIgGTYARFEFTRYDQK-KPGILGKL--------GPFLDDAVAGLIAGCTSRLYS 141 Methanoculleus marisni...
NP_614955    290 DPGw-VYFDEVLGQFVAMELgGYGALFNFKRYDEE-KPGILKEVde-----rWVMLDDVLAGLVAGAMTAAFR 355 Methanopyrus kandleri ...
YP_001056418 266 DSPr-LVADELLGVALADYLgGFQAVLTTYWVERVkKRGAFREL--------APFADDIMSALLASVYLSLYK 329 Pyrobaculum calidifont...
NP_558565    263 DTPr-IIIDELLGAALADYIgGFKAVLTTYWVERVkKDGGIPEL--------EMFRDDVLSALLAGVYLRLYE 326 Pyrobaculum aerophilum...

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