Conserved Protein Domain Family
NR_DBD_FXR

?
cd06962: NR_DBD_FXR 
DNA-binding domain of Farnesoid X receptor (FXR) family is composed of two C4-type zinc fingers
DNA-binding domain of Farnesoid X receptor (FXR) family is composed of two C4-type zinc fingers. Each zinc finger contains a group of four Cys residues which co-ordinates a single zinc atom. FXR interacts with specific DNA sites upstream of the target gene and modulates the rate of transcriptional initiation. FXR is a member of the nuclear receptor family of ligand activated transcription factors. Bile acids are endogenous ligands for FXRs. Upon binding of a ligand, FXR binds to FXR response element (FXRE), which is an inverted repeat of TGACCT spaced by one nucleotide, either as a monomer or as a heterodimer with retinoid X receptor (RXR), to regulate the expression of various genes involved in bile acid, lipid, and glucose metabolism. Like other members of the nuclear receptor (NR) superfamily of ligand-activated transcription factors, FXR has a central well conserved DNA binding domain (DBD), a variable N-terminal domain, a flexible hinge and a C-terminal ligand binding domain (LBD).
Statistics
?
PSSM-Id: 143520
View PSSM: cd06962
Aligned: 5 rows
Threshold Bit Score: 176.695
Threshold Setting Gi: 46577705
Created: 4-Feb-2009
Updated: 2-Oct-2020
Structure
?
Aligned Rows:
 
Feature 1:zinc binding site [ion binding site]
Evidence:
  • Comment:Zinc finger, C4-type: The domain contains two groups of four Cys residues. Each group is involved in the co-ordination of a single zinc atom.

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1           #  #             #  #               #     #         #  #                     
NP_989444    125 EELCVVCGDKASGYHYNALTCEGCKGFFRRSITKNAVYKCKNGGNCEMDMYMRRKCQECRLRKCKQMGMLAECLLTEIQC 204 chicken
NP_001082243 128 EELCVVCGDKASGYHYNALTCEGCKGFFRRSITKNAVYRCKNGGHCEMDMYMRRKCQECRLKKCKAVGMLAECLLTEVQC 207 African clawed ...
AAH92785     134 EELCVVCGDKASGYHYNALTCEGCKGFFRRSITKNAVYKCKSGGNCEMDMYMRRKCQECRLRKCKEMGMLAECLLTEIQC 213 zebrafish
NP_001123279  94 LELCLVCGDRASGFHYNALSCEGCKGFFRRSITKNAKYNCTRGGNCEMDMYMRRKCQECRLRKCREVGMLAECLLTEEQC 173 purple urchin
Q96RI1       134 DELCVVCGDRASGYHYNALTCEGCKGFFRRSITKNAVYKCKNGGNCVMDMYMRRKCQECRLRKCKEMGMLAECMYTGLLT 213 human
Feature 1            
NP_989444    205 KSKR 208 chicken
NP_001082243 208 KSKR 211 African clawed frog
AAH92785     214 KSKR 217 zebrafish
NP_001123279 174 KSKR 177 purple urchin
Q96RI1       214 EIQC 217 human

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap