Conserved Protein Domain Family
NR_LBD_TR2_like

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cd06952: NR_LBD_TR2_like 
The ligand binding domain of the orphan nuclear receptors TR4 and TR2
The ligand binding domain of the TR4 and TR2 (human testicular receptor 4 and 2): TR4 and TR2 are orphan nuclear receptors. Several isoforms of TR4 and TR2 have been isolated in various tissues. TR2 is abundantly expressed in the androgen-sensitive prostate. TR4 transcripts are expressed in many tissues, including central nervous system, adrenal gland, spleen, thyroid gland, and prostate. The expression of TR2 is negatively regulated by androgen, retinoids, and radiation. The expression of both mouse TR2 and TR4 is up-regulated by neurocytokine ciliary neurotrophic factor (CNTF) in mouse. It has shown that human TR2 binds to a wide spectrum of natural hormone response elements (HREs) with distinct affinities suggesting that TR2 may cross-talk with other gene expression regulation systems. The genes responding to TR2 or TR4 include genes that are regulated by retinoic acid receptor, vitamin D receptor, peroxisome proliferator-activated receptor. TR4/2 binds to HREs as a dimer. Like other members of the nuclea r receptor (NR) superfamily of ligand-activated transcription factors, TR2-like receptors have a central well conserved DNA binding domain (DBD), a variable N-terminal domain, a flexible hinge and a C-terminal ligand binding domain (LBD).
Statistics
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PSSM-Id: 132750
View PSSM: cd06952
Aligned: 12 rows
Threshold Bit Score: 331.99
Threshold Setting Gi: 110750942
Created: 19-Nov-2008
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative ligandputative
Feature 1:putative ligand binding site [chemical binding site]
Evidence:
  • Comment:predicted based on homologous proteins.
  • Citation:PMID 9744270

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                ##   #                                 #   #  #         
P49116       361 LLSDTHVTFKLTMPSPMPEYLNVHYICESASRLLFLSMHWARSIPAFQaLGQDCNTSLVRACWNELFTLGLAQCAqvmsl 440 human
Q503E0       365 LLSDMHVPFKLMMPLPMPDFLNLNYICESASRLLFLSMHWARSIPAFQaLGSENGITLMKACWNELFALGLAQCShimnv 444 zebrafish
NP_989455    334 LLSDAHVAFRLTMPSPMPEYLNVHYICETASRLLFLSMHWARSIPSFQaLGQDNSISLVKACWNELFTLGLAQCSqvmnv 413 chicken
Q66J63       402 LLNDVHIAFRLTMPSPMPEYLNVHYICESASRLLFLSMHWARSIPSFLsLGQENSISLVKACWNELFSLGLAQCCqvmnv 481 African clawed ...
Q26622       341 MLSDHHMQFKLTTPSPMPQFLNVHYICESASRLLFLSMHWARSLPAFQvLSADTHTSMVQKCWSELFTLGLAQCAqamal 420 Strongylocentro...
O61227       244 ILQEQHISFNLQIPGPVPPYLNIHYICESGSRLLFLSIHWTRNIPAFQyLTTETQITLLRGCWAELFTLGLAQCSqtlsl 323 yellow mealworm
Q4H2P1       408 LMTDSNFVFELTTPTPLPEVFNVHYVCESASRLLFLSAQWARSIFAFQlLRTECHTSLLRDCWHELFMLGLAQCSrsmnl 487 Ciona intestinalis
EEB14471     322 LLQDYHSTFNLQTPSPVPVHLNVHYVCESACRLLFLSIHWARSISAFQnLSHDLQVALVRRCWPELFALGLSQCSqilpl 401 human body louse
XP_392769    318 LISERHTLFELRAPSPAPAYLSIHYICESAARLLFLSVHWARGIPAFQaLPSEVQTTLVRSSWGQLFTLGLAQCAytlsl 397 honey bee
XP_001948311 247 VMPSVNVNFPFQSPSPKYAYLNLHFICESASRLLFLSINWVQSLPVFQlLTFEVQLSLLKSSWSQLFILGLTQCAqalsl 326 pea aphid
XP_555061    348 ALTEACVQFDIQVPTVLPSYLSVHYVCETGSRLLFATVHWMKKNHVFQmLGDGFQGELVRQVWPELFMIGLAQSSgqlsf 427 Anopheles gambi...
NP_524203    370 LLTDVQCAFHVQPPTLVHSYLNIHYVCETGSRIIFLTIHTLRKVPVFEqLEAHTQVKLLRGVWPALMAIALAQCQgqlsv 449 fruit fly
Feature 1            #                          #                                                
P49116       441 sTILAAIVNHLQNSiqedklsgdrikqvmehIWKLQEFCNSMakLDIDGYEYAYLKAIVLFSPDHpgl----tsTSQIEK 516 human
Q503E0       445 eTILTAIINHLQTSldeeklspervkqvmehIWRMQEFCNSMsrMSPDAYEYAYLKAVVLFSPDHsav----dgTLQIER 520 zebrafish
NP_989455    414 aTILAAFVNHLHDSlqqdklptdrgklvmehIFKLQEFCNSMvkLCLDGYEYAYLKAIVLLSPDHpgl----enVVQIEK 489 chicken
Q66J63       482 eTILAAFVNHLHNSmqhdklssdkvklvmdhIFKLQEFCNSMvkRCVDGYEYAYLKAIALFSPDHpgl----enVSHIEK 557 African clawed ...
Q26622       421 sTILTAIVNHLQTSlqqdklsadrvkavmehIWKLQEFVTTTskLDVDQTEFAYLKTIVLFSPDHpgl----snVRQIEK 496 Strongylocentro...
O61227       324 sTILSALISHLHTLiaqdkmsatkvkqvsdhIVKLQDYANTMnrLNVDEHEYAYLKAITLFSADQpdi----llRKHVEK 399 yellow mealworm
Q4H2P1       488 dRIIMTIIRHLKTSlqqgklttshvchvsehLNKLQDFVARLqkLEVDQHEYSYIKALALFSPDHvnq----lhRTQIQR 563 Ciona intestinalis
EEB14471     402 rAMLAPIIAYLRTAvtqdtmaaqrliditdhIFKLHEYVTRMvsLQIDNHEYAYLKALVLFSWHLpglp--lalKRQIDR 479 human body louse
XP_392769    398 pSILTSIINHLQASiaqekitaskvksvtehICRLQDCVSSLhkLQVDSIEYAYLKALTLFSADNvla---gvwRKKVEV 474 honey bee
XP_001948311 327 iPVLSSMITHLQNDeihnspnsskakelidyLNRIQDYITEMenIEVNDVEYAYLKLISLFNTDNps------eRQQLYK 400 pea aphid
XP_555061    428 nTIMLALIQYMKSAilnkkhsadvinylkkyILLIQEFVNDLqkLNLTDHEYAYLRLLSIFNPDNvlqd--kekNQHLVK 505 Anopheles gambi...
NP_524203    450 pTIIGQFIQSTRQLadidkieplkiskmanlTRTLHDFVQELqsLDVTDMEFGLLRLILLFNPTLlqqrkerslRGYVRR 529 fruit fly
Feature 1                                                                                        
P49116       517 FQEKAQMELQDYvqkty-----------------------------sedtyRLARILVRLPALRLMSsn-iTEELFFTGL 566 human
Q503E0       521 FQEKAYMELQDYvskvy-----------------------------pedtyRLSKLLVRLPALRLMSaa-vTEELFFAGL 570 zebrafish
NP_989455    490 FQEKAYMEFQDYvtkay-----------------------------pddtyRLSRLLLRLPALRLMSaa-iTEELFFAGL 539 chicken
Q66J63       558 LQEKAYMEFQDYvtkty-----------------------------pedtyRLSRLLLRLPALRLLNaa-iTEELFFAGL 607 African clawed ...
Q26622       497 FQEMAISELHDYeaqty-----------------------------psklnRFSKLLLRLPTLRLLSpa-iMEELFFAGL 546 Strongylocentro...
O61227       400 LQEKSFQALKTYvhnsf-----------------------------pddtdRFPRLLLRLPPLRGLEpl-vLEELFFAGL 449 yellow mealworm
Q4H2P1       564 FQSRATTELREHemrty-----------------------------pedpdRMSLLLLSLPALRSLSss-iTEEIFFAGL 613 Ciona intestinalis
EEB14471     480 LQEKALQELKSYvaknn-----------------------------seednRSSKLLLRLLPLRFLQpq-iMEELFFAGL 529 human body louse
XP_392769    475 LQEAAWTELQQRvg-----------------------------------snRLPRLLLRLAPLRSINpr-vLEDLFFAGL 518 honey bee
XP_001948311 401 LQEKAVKELKQHlikec------------------------------ndehRIAILLLRLPTLRSLQpn-iIEEIFFSSL 449 pea aphid
XP_555061    506 LQDLVLAEFRDYyrdrharlvsseseenlraneeddneddeeddyyerseqRLVKLLLKLPTLRALNskrdLEDLFFSNL 585 Anopheles gambi...
NP_524203    530 VQLYALSSLRRQggig-------------------------------ggeeRFNVLVARLLPLSSLDae-aMEELFFANL 577 fruit fly
Feature 1                        
P49116       567 IGNVSIDSIIPYILKM 582 human
Q503E0       571 IGNVQIDSIIPYILKM 586 zebrafish
NP_989455    540 IGNVQIDSIIPYILRM 555 chicken
Q66J63       608 IGNVQIDSIIPYILRM 623 African clawed frog
Q26622       547 IGNVQIDSIIPYILRM 562 Strongylocentrotus purpuratus
O61227       450 IGQVQIDSVIPYILRM 465 yellow mealworm
Q4H2P1       614 IGNVQIDSIIPYILKM 629 Ciona intestinalis
EEB14471     530 IGNVQIDSVIPYILRM 545 human body louse
XP_392769    519 IGRVSVASVVPYILTM 534 honey bee
XP_001948311 450 LGSFQIDAVIPQILKL 465 pea aphid
XP_555061    586 IGQVQIDSVLTYVIQT 601 Anopheles gambiae str. PEST
NP_524203    578 VGQMQMDALIPFILMT 593 fruit fly

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