3F5C


Conserved Protein Domain Family
NR_LBD_Dax1_like

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cd06951: NR_LBD_Dax1_like 
Click on image for an interactive view with Cn3D
The ligand binding domain of DAX1 protein, a nuclear receptor lacking DNA binding domain
The ligand binding domain of DAX1-like proteins: This orphan nuclear receptor family includes DAX1 (dosage-sensitive sex reversal adrenal hypoplasia congenita critical region on chromosome X gene 1) and the Small Heterodimer Partner (SHP). Both receptors have a typical ligand binding domain, but lack the DNA binding domain, typical to almost all of the nuclear receptors. They function as a transcriptional coregulator by directly interacting with other nuclear receptors. DAX1 and SHP can form heterodimers with each other, as well as with many other nuclear receptors. In addition, DAX1 can also form homodimers. DAX1 plays an important role in the normal development of several hormone-producing tissues. SHP has shown to regulate a variety of target genes.
Statistics
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PSSM-Id: 132749
View PSSM: cd06951
Aligned: 4 rows
Threshold Bit Score: 333.701
Threshold Setting Gi: 9978744
Created: 19-Nov-2008
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
putative ligandputativeheterotrimer
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:putative ligand binding site [chemical binding site]
Evidence:
  • Comment:predicted based on homologous proteins.
  • Citation:PMID 9744270

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                            ##   #                                 #   #  #          
3F5C_B     29 PRAPWWDASPgvqrl-itlkdPQVVCEAASAGLLKTLRFVKYLPCFQILPLDQQLVLVRSCWAPLLMLELAQDHLHFEMM 107 house mouse
ABB88831   35 TTAAHRCCSCasmrklvairaPQSVIRAACEVLLKTFRFVKNVPCFRGLPADDQLRLVRNSWAPLLLLGLVQDSVDFDTV 114 Nile tilapia
EEA55123  200 ATVLHRLAPEh----------YAMIHHAASQVLIQTIDFMRKLPAFTYLPPNDQMLLLMRSWHEIVAIGVAQEKVPIDTV 269 Florida lancelet
Q15466     32 VPRPRSRCLCrqhrp-vqlcaPHRTCREALDVLAKTVAFLRNLPSFWQLPPQDQRRLLQGCWGPLFLLGLAQDAVTFEVA 110 human
Feature 1         #                                           #                               
3F5C_B    108 EIPETNttQEMLTtrrqetegpepaepqateqpqmvsaeaghllpaaaVQAIKSFFFKCWsLNIDTKEYAYLKGTVLFNP 187 house mouse
ABB88831  115 ETQKPSllHEILThdanrrertag-------------aaqhpgvplcdVQSIQMFLVKCRgLTITVKEHAFLKGAILFTP 181 Nile tilapia
EEA55123  270 SVPAPP--CECCTgaemhwggtppp-----------tltmpgcilssdLDDIQQFVMKYQsLDLDCKEAAYLKAAVLFTP 336 Florida lancelet
Q15466    111 EAPVPSilKKILLeepsssggsgq-------------lpdrpqpslaaVQWLQCCLESFWsLELSPKEYACLKGTILFNP 177 human
Feature 1                                                                                
3F5C_B    188 DLPGlqcVKYIEGLQWRTQQILTEHIrmmqreyqiRSAELNSALFLLRFINSDVVTELFFRPIIGavsMDDMMLE 262 house mouse
ABB88831  182 VPELe-cQEYIHALQREAERALYEHVgtvyrgnasRSGKLRVVLSTLRAVDTEAVAGLFLRPVTGtssIDEHVLA 255 Nile tilapia
EEA55123  337 VPGLa-hPHYIEALQKEAQQALNEYTmmtrpletlRFARILLMVPLLRGIKQEPITELFFRPLIAnvrMEDVLRQ 410 Florida lancelet
Q15466    178 DVPGlqaASHIGHLQQEAHWVLCEVLepwcpaaqgRLTRVLLTASTLKSIPTSLLGDLFFRPIIGdvdIAGLLGD 252 human

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