Conserved Protein Domain Family
NR_LBD_Tlx_PNR_like

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cd06950: NR_LBD_Tlx_PNR_like 
The ligand binding domain of Tailless-like proteins, orphan nuclear receptors
The ligand binding domain of the photoreceptor cell-specific nuclear receptor (PNR) like family: This family includes photoreceptor cell-specific nuclear receptor (PNR), Tailless (TLX), and related receptors. TLX is an orphan receptor that is expressed by neural stem/progenitor cells in the adult brain of the subventricular zone (SVZ) and the dentate gyrus (DG). It plays a key role in neural development by promoting cell cycle progression and preventing apoptosis in the developing brain. PNR is expressed only in the outer layer of retinal photoreceptor cells. It may be involved in the signaling pathway regulating photoreceptor differentiation and/or maintenance. Like other members of the nuclear receptor (NR) superfamily of ligand-activated transcription factors, TLX and PNR have a central well conserved DNA binding domain (DBD), a variable N-terminal domain, a flexible hinge and a C-terminal ligand binding domain (LBD).
Statistics
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PSSM-Id: 132748
View PSSM: cd06950
Aligned: 17 rows
Threshold Bit Score: 264.927
Threshold Setting Gi: 74944729
Created: 19-Nov-2008
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative ligandputative
Feature 1:putative ligand binding site [chemical binding site]
Evidence:
  • Comment:predicted based on homologous proteins.
  • Citation:PMID 9744270

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                       ##   #                                 #   #  #  
Q5U3F3       201 DENIDVTSNEPERSspmygsa--lypsrePESVYETSARLLFMSVKWAKNLPVFshLPFRDQVILLEEAWSELFLLCAIQ 278 zebrafish
EEB17932     141 SFPIHFDSLVSKQNvwdlti---ssqqghPENVYESAAKLLFLTVKWARSIPSFlqLTFHDQSILLENTWNELFILSAAQ 217 human body louse
NP_001079280 154 QTLVGLAQPTPKYPhevngap-lylyefaTESVCESAARLLFMSIKWAKSVPAFstLSLQDQLMLLEDAWRELFVLGIAQ 232 African clawed ...
EEB14839     164 AAFLFGQTLIPKLTpnftltn--aiplgsVEALCESAARLLFMNVTWAKNVPAFtrLNYKDQLLLLEESWRELFVLSASQ 241 human body louse
Q6ZMP8       191 QTLVSLAQPTPKYPhevngtp-mylyevaTESVCESAARLLFMSIKWAKSVPAFstLSLQDQLMLLEDAWRELFVLGIAQ 269 human
NP_990501    154 QALVGLAQPTPKYPhevngtp-mylyevaTESVCESAARLLFMSIKWAKSVPAFstLSLQDQLMLLEDAWRELFVLGIAQ 232 chicken
Q9YGL3       165 QAIVGLAQPTPKYPhevsgtp-mylyevaTESVCESAARLLFMSIKWAKSVPAFstLPLSDQLILLEDAWRELFVLGIAQ 243 Japanese medaka
EEA42869     140 GCAADFKHSTIFQPvprypvevlqrwtckAEPVQEAAARLLNMTLHWLRSIPAFltLSSHDQHLLLQSSWQEMFLLGLAQ 219 Florida lancelet
O96680       469 CQELIQYQVQHNTLlfpqqll--dsrllsWEMLQETTARLLFMAVRWVKCLMPFqtLSKNDQHLLLQESWKELFLLNLAQ 546 fruit fly
XP_001897876 279 SSPISDSGKQDFSEifgsekidevrrgveNENVQEASTRLLFLAIKWAKNLPSFasLSLRDQLKLLKENWCDLFLLSVFQ 358 agent of lympha...
Feature 1                   #                    #                                               
Q5U3F3       279 WSLPldncPLLSLpdLSPTgqgkgs--psasdVRVLQEVFSRFKpLQVDPTEFACLKAIVLFKpetr------------- 343 zebrafish
EEB17932     218 WTLPvdeeYLVRVtsLPNNkakek----fereVKNFKKIITKFNnLNVDYTEYACLKALTLFKaets------------- 280 human body louse
NP_001079280 233 WAIPvdasTLLAVsgMNNEntespklnkiiseIQALQDVVSRFRqLRLDATEFACLKCIVTFKagvsthsg--------- 303 African clawed ...
EEB14839     242 FMLPlelvDLLTAhtTVTAnsekal--tiaqeVKQFQETLIKFKqLHVDIHEYACLRAIVLFKtsfdpsnntvtsstaps 319 human body louse
Q6ZMP8       270 WAIPvdanTLLAVsgMNGDntdsqklnkiiseIQALQEVVARFRqLRLDATEFACLKCIVTFKavpthsgs--------- 340 human
NP_990501    233 WAIPvdanTLLAVsgMNGDntdsqklnkiiseIQALQEVVARFRqLRLDATEFACLKCIVTFKavpthsgs--------- 303 chicken
Q9YGL3       244 WAIPvdstTLLAVsgLNSEnmeaqrmnkimaeIQALQEVVTRFRqMRLDATEFACLKCIVTFKavptqgsa--------- 314 Japanese medaka
EEA42869     220 WALPmdpkQLAVEagVPPDqspadrlqtflqqVQMLQETLHKFHqLQVDAVEYACLKGIVLFKtgetisqttc------- 292 Florida lancelet
O96680       547 WTIPldltPILESplIRERvlqde---atqteMKTIQEILCRFRqITPDGSEVGCMKAIALFApeta------------- 610 fruit fly
XP_001897876 359 WSLPmdkcPLLNTlqTDPSs------------FRYLNDLFFRIRsYGIDHGEFACLKAIVLFRpetr------------- 413 agent of lympha...
Feature 1                                                                             
Q5U3F3       344 ------glkdPEQVENLQDQSQVLLAQHihtlypsqvaRFGRLLLLLPSLHFVsserIEHLFFQRTIGN 406 zebrafish
EEB17932     281 ------elkdRLQVEMLQDQTHIMLHDYctsqd-shkaRFGKLLMLLPSVNGLskdfIEELLFRKTIGI 342 human body louse
NP_001079280 304 --selrnfrnAAAISALQDEAQLTLNSYihtryptqpcRFGKLLLLLPALRSInpstIEEVFFKKTIGN 370 African clawed frog
EEB14839     320 ssgegktlhdLAEVAAVQDHTQLTLNKYisaahptqpfRFGKLLLLLPSLRSVsnntIEELFFRRTIGN 388 human body louse
Q6ZMP8       341 ---elrsfrnAAAIAALQDEAQLTLNSYihtryptqpcRFGKLLLLLPALRSIspstIEEVFFKKTIGN 406 human
NP_990501    304 ---elrsfrnAAAIAALQDEAQLTLNSYihtryptqpcRFGKLLLLLPALRSIspstIEEVFFKKTIGN 369 chicken
Q9YGL3       315 ---elrafrnASAIAALQDEAQLTLNSYihtryptqpcRFGKLLLLLPALRSVspstIEEVFFKKNIGN 380 Japanese medaka
EEA42869     293 cftdvqslrdPGTVAVLQDQTQLSFSHHiemhkpgqpfRFGKLLLLLSSLREVqrssLESVFFTKTMTG 361 Florida lancelet
O96680       611 ------glcdVQPVEMLQDQAQCILSDHvrlryprqatRFGRLLLLLPSLRTIraatIEALFFKETIGN 673 fruit fly
XP_001897876 414 ------glknLVQIEDLQDQAQQTLAKHtmns---spaRFGRLLLLLPLLRTIsaekIERMFFMATFGN 473 agent of lymphatic filariasis

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