1XP9,1YY4


Conserved Protein Domain Family
NR_LBD_ER

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cd06949: NR_LBD_ER 
Click on image for an interactive view with Cn3D
Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
The ligand binding domain (LBD) of Estrogen receptor (ER): Estrogen receptor, a member of nuclear receptor superfamily, is activated by the hormone estrogen. Estrogen regulates many physiological processes including reproduction, bone integrity, cardiovascular health, and behavior. The main mechanism of action of the estrogen receptor is as a transcription factor by binding to the estrogen response element of target genes upon activation by estrogen and then recruiting coactivator proteins which are responsible for the transcription of target genes. Additionally some ERs may associate with other membrane proteins and can be rapidly activated by exposure of cells to estrogen. Like other members of the nuclear receptor (NR) superfamily of ligand-activated transcription factors, ER has a central well conserved DNA binding domain (DBD), a variable N-terminal domain, a flexible hinge and a C-terminal ligand binding domain (LBD). The C-terminal LBD also contains AF-2 activation motif, the dimerization motif, and part of the nuclear localization region. Estrogen receptor has been linked to aging, cancer, obesity and other diseases.
Statistics
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PSSM-Id: 132747
View PSSM: cd06949
Aligned: 8 rows
Threshold Bit Score: 326.691
Threshold Setting Gi: 146742358
Created: 19-Nov-2008
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 7 residues -Click on image for an interactive view with Cn3D
Feature 1:ligand binding site [chemical binding site]
Evidence:
  • Structure:1XP9_a; human estrogen receptor alpha binds to a Dihydrobenzoxathiin, molecule 18, contacts at 3.5A
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                #    # #                             
1XP9_A      4 LTADQMVSALLDAEPPILYSEYdptr-------pfsEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECA 76  human
1YY4_A      1 LSPEQLVLTLLEAEPPHVLISRpsa--------pftEASMMMSLTKLADKELVHMISWAKKIPGFVELSLFDQVRLLESC 72  human
ACB10649  303 NPTVPLISHLVNIEPNPILTGYnpqc-------tptEGYLMALVTDLANREIEGLVDWAARLPGYGMLPMDDQVNLIRTV 375 Florida lancelet
Q7ZU32    280 LSPEELISRIMEAEPPEIYLMKdmkk-------pftEANVMMSLTNLADKELVHMISWAKKIPGFVELSLFDQVHLLECC 352 zebrafish
P06212    304 LTAEQMVSALLEAEPPIVYSEYdpnr-------pfnEASMMTLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECA 376 chicken
P81559    302 LTAEQLISALMEAEAPIVYSEHdstk-------plsEASMMTLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECA 374 African clawed frog
ABQ42696  226 QRLKALIDALDVKEGEHRGEENhptgqqagnwqeisNPELIESVSSLVDRELTGIICWGKKIPGYSKLSLNDQVLLMEST 305 Florida lancelet
ACC85903  141 LSSEQFLTCLLNAEPPNMTCHHdvsr-------pftAERLMMLLTNLADRELVHMIGWAKKVPGFVQISLRDQVLLLESS 213 Atlantic hagfish
Feature 1         #      #                                                                    
1XP9_A     77 WLEILMIGLVWRSMEHPG-KLLFAPNLLLDRNQGKc--------VEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIIL 147 human
1YY4_A     73 WMEVLMMGLMWRSIDHPG-KLIFAPDLVLDRDEGKc--------VEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMIL 143 human
ACB10649  376 WLDLLMLGLVWRSMEHRGeWLVFAPDLLMDRSLCR---------LSGMEYICTPMLEFARQFADLQVPQEVYVCLKALTL 446 Florida lancelet
Q7ZU32    353 WLEVLMLGLMWRSVNHPG-KLIFSPDLCLSRDESSc--------VQGLVEIFDMLLAATSRFRELKLQREEYVCLKAMIL 423 zebrafish
P06212    377 WLEILMIGLVWRSMEHPG-KLLFAPNLLLDRNQGKc--------VEGMVEIFDMLLATAARFRMMNLQGEEFVCLKSIIL 447 chicken
P81559    375 WLEILMVGLIWRSVEHPG-KLSFAPNLLLDRNQGRc--------VEGLVEIFDMLVTTATRFRMMRLRGEEFICLKSIIL 445 African clawed frog
ABQ42696  306 WLDLLILDLVWCSIRHKGeKLLLSGGVLVNRNTISnrrnnssgdDMEVLEMCDQILSIATKFYEFDLQRREYLCLKAITL 385 Florida lancelet
ACC85903  214 WLEVLIMGLIWRSMSQPG-KLVFASNLILDRDDGEc--------VEGIFEIFDILLNIVQHFRELQVWMDEYVCLKAIIL 284 Atlantic hagfish
Feature 1                                                                        #  #         
1XP9_A    148 LNSGVYtflsstlksLEEKDHIHRVLDKITDTLIHLMAKAgltlqQQHQRLAQLLLILSHIRHMSNKGMEHLysMKCKNV 227 human
1YY4_A    144 LNSSMYplvt-atqdADSSRKLAHLLNAVTDALVWVIAKSgissqQQSMRLANLLMLLSHVRHASNKGMEHLlnMKCKNV 222 human
ACB10649  447 YTTAVSr--------LQDYRQVQRLQHEINEALAEACSSTf---gFSPGNIARLMMIVSQVRQLSSLGVDHLnrLRGAET 515 Florida lancelet
Q7ZU32    424 LNSNMClgsseggedLQSRSKLLCLLDSVTDALVWAISKTglsfqQRSTRLAHLLMLLSHIRHVSNKGMDHLhcMKMKKM 503 zebrafish
P06212    448 LNSGVYtflsstlksLEERDYIHRVLDKITDTLIHLMAKSglslqQQHRRLAQLLLILSHIRHMSNKGMEHLynMKCKNV 527 chicken
P81559    446 LNSGVYtflsstlesLEDTDLIHIILDKIIDTLVHFMAKSglslqQQQRRLAQLLLILSHIRHMSNKGMEHLysMKCKNV 525 African clawed frog
ABQ42696  386 VHGSLKg--------LESDTQVRQLQDDLTDALMDVCSERh---aLGSRRPAKMLLLLSHLRQVSARASSHLgaVRNGLK 454 Florida lancelet
ACC85903  285 LNASMMvat---sekDGSRAKVQQLVEATTDTLVKCIARRslatpEQFRRLSHLLTILSHIRHISNKGIQHMysMKCKNL 361 Atlantic hagfish
Feature 1                   
1XP9_A    228 VPLYDLLLEMLDAH 241 human
1YY4_A    223 VPVYDLLLEMLNAH 236 human
ACB10649  516 VSVEGLLREIVDEP 529 Florida lancelet
Q7ZU32    504 VPLYDLLLEMLDAH 517 zebrafish
P06212    528 VPLYDLLLEMLDAH 541 chicken
P81559    526 VPLYDLLLEMLDAH 539 African clawed frog
ABQ42696  455 VPLYDILLDILTDQ 468 Florida lancelet
ACC85903  362 VPFYDLLLEMLDAH 375 Atlantic hagfish

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