1XB7,2PJL,1KV6,2PJL


Conserved Protein Domain Family
NR_LBD_ERR

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cd06946: NR_LBD_ERR 
Click on image for an interactive view with Cn3D
The ligand binding domain of estrogen receptor-related nuclear receptors
The ligand binding domain of estrogen receptor-related receptors (ERRs): The family of estrogen receptor-related receptors (ERRs), a subfamily of nuclear receptors, is closely related to the estrogen receptor (ER) family, but it lacks the ability to bind estrogen. ERRs can interfere with the classic ER-mediated estrogen signaling pathway, positively or negatively. ERRs share target genes, co-regulators and promoters with the estrogen receptor (ER) family. There are three subtypes of ERRs: alpha, beta and gamma. ERRs bind at least two types of DNA sequence, the estrogen response element and another site, originally characterized as SF-1 (steroidogenic factor 1) response element. Like other members of the nuclear receptor (NR) superfamily of ligand-activated transcription factors, ERR has a central well conserved DNA binding domain (DBD), a variable N-terminal domain, a flexible hinge and a C-terminal ligand binding domain (LBD).
Statistics
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PSSM-Id: 132744
View PSSM: cd06946
Aligned: 12 rows
Threshold Bit Score: 320.081
Threshold Setting Gi: 74935853
Created: 19-Nov-2008
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 13 residues -Click on image for an interactive view with Cn3D
Feature 1:ligand binding site [chemical binding site]
Evidence:
  • Structure:1PJL; human ERR alpha binds synthetic inverse agonist, contacts at 4A
    View structure with Cn3D
  • Comment:agaonist: 1-cyclohexyl-N-[[1-(4-methylphenyl)indol-3-yl]methyl]methanamine

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                           #  #   #  #  
1XB7_A        21 LVSHLLVVE--PEKLYAMPDpa-------------------------------------gPDGHLPAVATLCDLFDREIV 61  human
2PJL_B        21 LVSHLLVVE--PEKLYAMPDpa-------------------------------------gPDGHLPAVATLSDLFDREIV 61  human
Q8WS79       237 ILEVLNSYE--PDALSVQTPppqvhttsitndeassssgsiklessvvtpngtcifqnnnNNDPNEILSVLSDIYDKELV 314 fruit fly
Q5RJ38       193 VVTLLLGAE--PEKVCAMPDpa-------------------------------------lPDSDIKALTTLCDLADRELV 233 zebrafish
ABI97120     201 ILNTLLALEsqLDKLFASSDpf-------------------------------------lPDDDVKFRAAVSDLADRELV 243 Marisa cornuari...
Q4H3L1       289 ILSHLLMAE--PDKLFAPHDhs-------------------------------------aTRSEISILTALCDLADRELV 329 Ciona intestinalis
NP_001007082 214 IVSHLLVAE--PEKIYAMPDpt-------------------------------------vPDSDIKALTTLCDLADRELV 254 chicken
Q6AX97       186 VVSHLLVAE--PDKLFAMPDpa-------------------------------------lPDGDLKYMSTLCDLADREIV 226 African clawed ...
XP_392385    223 MLEALAACE--PDMLQVSNIsh-------------------------------------tLDTDQRVLGQLSDLYDRELV 263 honey bee
EEB18499     226 ILEALSLNE--PDISVMAQDis-------------------------------------nADPAVRTLNILSDLYDQELV 266 human body louse
1KV6_A         9 IVSHLLVAE--PEKIYAMPDpt-------------------------------------vPDSDIKALTTLCDLADRELV 49  human
2PJL_A        21 LVSHLLVVE--PEKLYAMPDpa-------------------------------------gPDGHLPAVATLSDLFDREIV 61  human
Feature 1                                           #            #   #          ###              
1XB7_A        62 VTISWAKSIPGFSSLSLSDQMSVLQSVWMEVLVLGVAQRSLPLQDELAFAEDLVLDee-gARAAGLGELGAALLQLVRRL 140 human
2PJL_B        62 VTISWAKSIPGFSSLSLSDQMSVLQSVWMEVLVLGVAQRSLPLQDELAFAEDLVLDee-gARAAGLGELGAALLQLVRRL 140 human
Q8WS79       315 SVIGWAKQIPGFIDLPLNDQMKLLQVSWAEILTLQLTFRSLPFNGKLCFATDVWMDeh-lAKECGYTEFYYHCVQIAQRM 393 fruit fly
Q5RJ38       234 LNISWAKHIPGFSSLSLSDQMSLLQSAWMEILVLRVAFRSLPCDDRLLFADDYIMDae-qAKCAGLLELHTAILQLVRRY 312 zebrafish
ABI97120     244 ITISWAKQVPGFTNLSLMDQMNLLQHSWLEILCLNLVFRSCPYNGHVCYAEDLRVPasmvETYNIPLELDSLTRKLCKKF 323 Marisa cornuari...
Q4H3L1       330 VIIGWAKHIPGFTVLSLADQMALLQSAWMEVLVLGIVFRSLSRDGDLVIAEDFILDae-nCAEVGMVELYHYLNQLQRRL 408 Ciona intestinalis
NP_001007082 255 VIIGWAKHIPGFSTLSLADQMSLLQSAWMEILILGVVYRSLSFEDELVYAEDYIMDed-qSKLAGLLDLNNAILQLVKKY 333 chicken
Q6AX97       227 IIISWAKNIPGFSSLSLSDQMSLLQSVWMEVLLLGVVFRSLPYEDEVVFAEDFVLDee-sSRSGRLTDLCSCVLHLVRKY 305 African clawed ...
XP_392385    264 GIIGWAKQIPGFSSLALNDQMRLLQSTWAEILTFSLAWRSMPNNGRLRFAQDFTLDer-lARECHCTELYTHCIQIVERL 342 honey bee
EEB18499     267 KIITWAKHIPGFLDLTLNDQMRLLQSTWAEILTLTVTYRSLPGTGELKFAADFSFDek-mARECGAMDIYQHCMHIVERQ 345 human body louse
1KV6_A        50 VIIGWAKHIPGFSTLSLADQMSLLQSAWMEILILGVVYRSLSFEDELVYADDYIMDed-qSKLAGLLDLNNAILQLVKKY 128 human
2PJL_A        62 VTISWAKSIPGFSSLSLSDQMSVLQSVWMEVLVLGVAQRSLPLQDELAFAEDLVLDee-gARAAGLGELGAALLQLVRRL 140 human
Feature 1                                                                                        
1XB7_A       141 QALRLEREEYVLLKALALANSDSVHiEDAEAVEQLREALHEALLEYEAgragpg-ggaerRRAGRLLLTLPLLRQTAGKV 219 human
2PJL_B       141 QALRLEREEYVLLKALALANSDSVHiEDAEAVEQLREALHEALLEYEAgragpg-ggaerRRAGRLLLTLPLLRQTAGKV 219 human
Q8WS79       394 ERISPRREEYYLLKALLLANCDILL-DDQSSLRAFRDTILNSLNDVVYllrh----ssavSHQQQLLLLLPSLRQADDIL 468 fruit fly
Q5RJ38       313 RCMSLEREEFVTLKAIALANSDSMHiEDVEAVQGLQDALHEALLDYECvhhs-----edpRRAGKLIMTLPLLRQTSAKA 387 zebrafish
ABI97120     324 TYLGVSKEEYVLLKAIILCNIDVVV-ETGETVRGLQDKLQDSLIECIKarhc-----gnpRRLGQLFLLLPPITHIKLLA 397 Marisa cornuari...
Q4H3L1       409 KQLNFKKEEFVLMKAIALVNSDSLHvENHQTLRQLQDTLLQTLSDTVQstpsntattfafQRCGQLLLTLPLLRLAAVKA 488 Ciona intestinalis
NP_001007082 334 KSMKLEKEEFVTLKAIALANSDSMHiEDVEAVQKLQDVLHEALQDYEAgqhm-----edpRRAGKMLMTLPLLRQTSTKA 408 chicken
Q6AX97       306 RTLRVEKEEYVMLKALTLTNSDSVHiEDPDAVLRLRDALQEALSEYESgrhp-----eepCRDGKLLLTLPLLRQTAGRV 380 African clawed ...
XP_392385    343 QRLGLTREEYYVLKALILANSDARS-DEPQALYRFRDSILNSLSDCMAavrp----gqalRATQNMFLVLPSLRQVDGIV 417 honey bee
EEB18499     346 EKLNITKEEYYIIKALVLANSDVRI-DDLPPLKKLRDNILSALADCVAvlrp----nttsLHMNHLLLCLPALRQADYIN 420 human body louse
1KV6_A       129 KSMKLEKEEFVTLKAIALANSDSMHiEDVEAVQKLQDVLHEALQDYEAgqhm-----edpRRAGKMLMTLPLLRQTSTKA 203 human
2PJL_A       141 QALRLEREEYVLLKALALANSDSVHiEDAEAVEQLREALHEALLEYEAgragpg-ggaerRRAGRLLLTLPLLRQTAGKV 219 human
Feature 1           #  # #                
1XB7_A       220 LAHFygVKLEGKVPMHKLFLEMLEA 244 human
2PJL_B       220 LAHFygVKLEGKVPMHKLFLEMLEA 244 human
Q8WS79       469 RRFWrgIARDEVITMKKLFLEMLEP 493 fruit fly
Q5RJ38       388 VRHFcsIKQDGRVPMHKLFLELLEA 412 zebrafish
ABI97120     398 KQFWfdLKKDGRVMMHKLFLEMLEA 422 Marisa cornuarietis
Q4H3L1       489 VHFFntVRQSGKVVLHKLFLEMLDA 513 Ciona intestinalis
NP_001007082 409 VQHFynIKLEGKVPMHKLFLEMLEA 433 chicken
Q6AX97       381 LQHFhaLREEGAVPMHKLFLEMLEA 405 African clawed frog
XP_392385    418 RRFWssVYRTGKVPMNKLFVEMLEA 442 honey bee
EEB18499     421 RRFWtaVHREGKVYMNKLFIEMLES 445 human body louse
1KV6_A       204 VQHFynIKLEGKVPMHKLFLEMLEA 228 human
2PJL_A       220 LAHFygVKLEGKVPMHKLFLEMLEA 244 human

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