1YUC,2IZ2,1YOW,1PK5,1YOK,1ZDU,1ZH7,1YP0,1YMT,1ZDT


Conserved Protein Domain Family
NR_LBD_Ftz-F1_like

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cd06944: NR_LBD_Ftz-F1_like 
Click on image for an interactive view with Cn3D
The ligand binding domain of FTZ-F1 like nuclear receptors
The ligand binding domain of FTZ-F1 like nuclear receptors: This nuclear receptor family includes at least three subgroups of receptors that function in embryo development and differentiation, and other processes. FTZ-F1 interacts with the cis-acting DNA motif of ftz gene, which required at several stages of development. Particularly, FTZ-F1 genes are strongly linked to steroid biosynthesis and sex-determination; LRH-1 is a regulator of bile-acid homeostasis, steroidogenesis, reverse cholesterol transport and the initial stages of embryonic development. SF-1 is an essential regulator of endocrine development and function and is considered a master regulator of reproduction; SF-1 functions cooperatively with other transcription factors to modulate gene expression. Phospholipids have been identified as potential ligand for LRH-1 and steroidogenic factor-1 (SF-1). However, the ligand for FTZ-F1 has not yet been identified. Most nuclear receptors function as homodimer or heterodimers. However, LRH-1 and SF-1 bind to DNA as a monomer. Like other members of the nuclear receptor (NR) superfamily of ligand-activated transcription factors, receptors in this family have a central well conserved DNA binding domain (DBD), a variable N-terminal domain, a flexible hinge and a C-terminal ligand binding domain (LBD).
Statistics
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PSSM-Id: 132742
View PSSM: cd06944
Aligned: 31 rows
Threshold Bit Score: 325.775
Threshold Setting Gi: 122049727
Created: 19-Nov-2008
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
ligand bindingcoactivator
Conserved site includes 14 residues -Click on image for an interactive view with Cn3D
Feature 1:ligand binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                 #  ##                                  
1YUC_A        15 IPHLILELLKCEPDePQVQAKIMAYLQQEqanrskheklstFGLMCKMADQTLFSIVEWARSSIFFReLKVDDQMKLLQN 94  human
2IZ2_A        11 VSPXIREFVQSIDD-REWQTQLFALLQKQtynqv---evdlFELXCKVLDQNLFSQVDWARNTVFFKdLKVDDQXKLLQH 86  fruit fly
EEA66728     214 PKLMQELLQCEPDQkVLRQKLLETVEDQMrqge----epnsFVMLCKLADRSLVSTVEWAKNNAMFSqLEVEDQMALLQN 289 Florida lancelet
Q4H3G7       272 VPLLIDQLLKYEIVeSEIKTRIGTSLLDVthr------sdvFQLICKIADQTLYAMVEWAKKSVFFAdLQVSDQMKLLQD 345 Ciona intestinalis
Q98ST8       297 SSFFLNQLLQAEPDeKQLCMRVLASLQREqacrgkhdrlntFSIMCKMADQTLFGLVEWARNCELFKeLKVDDQMVLLQS 376 zebrafish
CAQ57670     368 KYSPIIRDFVQTVDdREWQKSLFELLQNQtynqc---evdlFELMCKVLDQNLFSQVDWARNSVFFKdLKVDDQMKLLQH 444 German cockroach
AAL50351     306 RVSPMIREFVQTIDdREWQNSLFGLLQSQtynqc---evdlFELMCKVLDQNLFSQVDWARNTVFFKyLKVDDQMKLLQH 382 tobacco hornworm
XP_001945464 480 GMSPMIRDFVQGLDdREWQSSLFGLLQNQtynqc---evdlFELMCKVLDQNLFSQVDWARNSVFFKdLKVDDQMKLLQH 556 pea aphid
XP_791919    254 TPKLIQELIRSEPDqAQLQAKVASYFQSAmgmta---pgdfFSMVCKLADQTLFAFVDWARNSLFFKeLKVEDQMKLLQN 330 purple urchin
ACH68437     242 TPRLITEMVRSEPDyKQLQAKIRTCLQSQmemng---ptdyFGMACKLADQTLFAFVDWARNSMFFKdLKVEDQMKLLQN 318 Saccoglossus ko...
Feature 1         ##  #   #              #                      ##                               
1YUC_A        95 CWSELLILDHIYRQVvhgkegSIFLVTGQQVDYsiiasqa-gatlnnLMSHAQELVAKLRsLQFDQREFVCLKFLVLFSl 173 human
2IZ2_A        87 SWSDXLVLDHLHHRIhnglpdETQLNNGQVFNLxslgl----lgvpqLGDYFNELQNKLQdLKFDXGDYVCXKFLILLNp 162 fruit fly
EEA66728     290 CWSELLVLEHLYRRAvsg-kdCLMTSQGQEINMslips-----lgfgPMDCTAEVASKLReAKVDYLEYMCLKFLILFNt 363 Florida lancelet
Q4H3G7       346 SWIELLILDHIQRQLklk-sdSIELVTGHKFSRdlskvsshcvitfrILKRLMDLEKKFAvLQVDEQEIACLKYLVLFDt 424 Ciona intestinalis
Q98ST8       377 CWSELLVLDHLCRQVaygrdgSICLITGQQIEAstilsqa-gvtlssLVSRAQDLVTKLRsLQLDREEFVCLKYLVLFNp 455 zebrafish
CAQ57670     445 SWSDMLVLDHMHQRMhnnlpdETTLPNGQKFDLlclgl----lgvptLADHFSDLMAKLQdLKFDVTDYICVKFLLLLNp 520 German cockroach
AAL50351     383 SWSDMLVLDHLHQRMhnglpdETTLHNGQKFDLlclgl----lgvpaLADHFNELQNKLAeLKFDVPDYICVKFLLLLNp 458 tobacco hornworm
XP_001945464 557 SWSDMLVLDHIHQHMhnnlanEIMLHNGQKFDLlalgl----lgvttMADCFAQVIDRLQeLKFDVGDYICLKFLLLLNp 632 pea aphid
XP_791919    331 SWSELLLFDHLYRQIhhh-geGVLMITGHTLDQatlsh----mgpadVIDQMGNIVMRMReLKLDHKDYVCLKFMILLNp 405 purple urchin
ACH68437     319 AWSELLVIDQCYRQVesn-veEMILVTGEVLDVaklrm----yglgdIVDRMTEIIKRMKeLKMDRKEFMCLKFLLLLNp 393 Saccoglossus ko...
Feature 1                                                             #  ##  #                   
1YUC_A       174 dvknleNFQLVEGVQEQVNAALLDYtmcnypqqteKFGQLLLRLPEIRAISMQAEEYLYYKHLngdvpynNLLIEMLHAK 253 human
2IZ2_A       163 svrgivNRKTVSEGHDNVQAALLDYtltcypsvndKFRGLVNILPEIHAXAVRGEDHLYTKHCagsaptqTLLXEXLHAK 242 fruit fly
EEA66728     364 dvkglvNRSMLEKFQEQINVALLDYtlcnypeqndRFGQLLLRLPEIRLIAVQAEELMYLKHLngilpsaTLLMEMLHAK 443 Florida lancelet
Q4H3G7       425 e----sHTAGCPNVQEKVNEALCEYskknymdqpdRVNKLIFRLSEIRAVSSQIEDYLHYKHHegkltegSLLVELLKAR 500 Ciona intestinalis
Q98ST8       456 dvksvqNRRQVEQTQERVNKALMDHtmqthpghsdKFGQLLLRLPEVRSISLQVEEYLYQRHLlgdfpcnSLLTEMLHAK 535 zebrafish
CAQ57670     521 evrgimNRRHVQEGYDQVQQALMDYtvncypqiqdKFTKLLLVLPEIHHMASRGEEHLYHKHCnggaptqTLLMEMLHAK 600 German cockroach
AAL50351     459 evrgivNVKCVRDGYQTVQAALLDYtltcyptvqdKFGKLVMVVPEIHALAARGEEHLYQRHCagqaptqTLLMEMLHAK 538 tobacco hornworm
XP_001945464 633 dvkgigNSKHVHEGHEQVLKALLDYcitansqvqdKFTKLLSVLPEIHHIATRGEESLYLKHCsggaptqTLLMEMLHAK 712 pea aphid
XP_791919    406 givalhDKHIIDGCQDQISAALLEHtmtaytnvsdKFRLMLRLLPEIRQISQRAEEYLYYKHLngevpynSLLMEMLHSK 485 purple urchin
ACH68437     394 dvpglqDNHAIRQFQEQIHAALLDYtmsnypevteKFGQLLLRLPEIRQISLQGEEYLYYKHLsgevpynSLLMEMLHSK 473 Saccoglossus ko...

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