Conserved Protein Domain Family
NR_LBD_Sex_1_like

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cd06942: NR_LBD_Sex_1_like 
The ligand binding domain of Caenorhabditis elegans nuclear hormone receptor Sex-1 protein
The ligand binding domain (LBD) of Caenorhabditis elegans nuclear hormone receptor Sex-1 protein like: Sex-1 protein of C. elegans is a transcription factor belonging to the nuclear receptor superfamily. Sex-1 plays pivotal role in sex fate of C. elegans by regulating the transcription of the sex-determination gene xol-1, which specifies male (XO) fate when active and hermaphrodite (XX) fate when inactive. The Sex-1 protein directly represses xol-1 transcription by binding to its promoter. However, the active ligand for Sex-1 protein has not yet been identified. Like other members of the nuclear receptor (NR) superfamily of ligand-activated transcription factors, Sex-1 like receptors have a central well conserved DNA binding domain (DBD), a variable N-terminal domain, a non-conserved hinge and a C-terminal ligand binding domain (LBD).
Statistics
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PSSM-Id: 132740
View PSSM: cd06942
Aligned: 11 rows
Threshold Bit Score: 181.394
Threshold Setting Gi: 24418858
Created: 9-Dec-2008
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative ligandputative
Feature 1:putative ligand binding site [chemical binding site]
Evidence:
  • Comment:predicted based on homologous proteins.
  • Citation:PMID 9744270

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1              ##   #                                 #   #  #             # #            
AAC77795      296 LNAWQIYAHEIDVDIKEVVNFVKEIPKFnfINGNDKAVLLRKNAFPLYLLRIVRGMSnr---glMLRDGRlidfksl--- 369  nematode
AAW88534     1306 EDIWGQMMKHFETHSRFIVQFVKYIPGFcyLKISDQRQLVRSAMYPIMLLELSRDYVnedrtryNYFDFTpeehaiil-- 1383 Schistosoma m...
Q611B9        298 LNAWKVFGHNIEMEVQNAIYFVRDIPRTefVSGDDKAALLKKNIFGIYLCRIFRSLSee---gmVMHDGRvtnvptl--- 371  Caenorhabditi...
ABS29716      306 QTICPVGRANAHHAIKAAYDFSQSIPGFnmLHHQDRVQLLKGTLFQTIVLAMLSSFNsn---ktLLMFQSpvgqy----- 377  dog heartworm...
AAR32910     1132 NQVWGHMMNHFHMHAQQVVQFAKLVPGFnqLGITARSNLVREAMYSVLLLLLSRDYCpet-deyNYFDFPakerevim-- 1208 Schistosoma m...
ABU89802      169 FEKMGKIATSMEKNIRNIVEFVRLIPGYsqLSTKDRLQLIKSCFSDYWFLAAHKRINle---lqVVCGSVnahfdel--- 242  Mediterranean...
P41828        384 AGGWELFARELNPLIQAIIEFAKSIDGFmnLPQETQIQLLKGSVFELSLVFAAMYYNvd---aqAVCGERysvpfaclia 460  Caenorhabditi...
XP_001901465  251 FDAWKKFAAELTRIIQCIIEFAKMVEGFmqLSQEEQIALLKGCVFELAAIVVTRHYNpe---ttSLILSRevfpasifrp 327  agent of lymp...
AAW88550     1651 EIFWHHLMKYFESHIYEIIQFAQSIPNFqeLSEFDMKILIQQSIYPIILIQLSQDFNnnk--tkEYYYFNiqsqtsli-- 1726 Schistosoma m...
AAR29356     1132 NQVWGHMMNHFHMHAQQVVQFAKLVPGFnqLGITARSNLVREAMYSVLLLLLSRDYCpet-deyNYFDFPakerevim-- 1208 Schistosoma m...
P41830        296 LNAWQIYAHEIDVDIKEVVNFVKEIPKFnfINGNDKAVLLRKNAFPLYLLRIVRGMSnr---glMLRDGRlidfksl--- 369  Caenorhabditi...
Feature 1                 #                                                                       
AAC77795      370 -qllygsLADEMLAFANHIi-tIGCTDGDIALFIVLILCQPLt----------tEQQFSTNFKSQLQLLEMFDFYKkvlf 437  nematode
AAW88534     1384 shfptfhKISGHLIRSGEFltrLNLDNIELTLMCAQEVFKDRqg---------lDDPVTPAYLFNLVGLALTEHIIsvgy 1454 Schistosoma m...
Q611B9        372 -rllfgcLADEMIQFAVYCr-nIGVSDADMAILAALVLVQPAg----------lDYRQDVQNKGPPGLAQLIQFFQnmmh 439  Caenorhabditi...
ABS29716      378 ---vhqyFYSPLNVFLQKFn-tLKLTNQQVALIGAAGMCISDkp---------lLHHPELAAFIHNRLSDLFQETFse-- 442  dog heartworm...
AAR32910     1209 rhfptfkRITEHLRVSGRImhhLNLSLPELSLSCAAEILRNY------------CILEEPTAKSTAELFVLAHHSLlncm 1276 Schistosoma m...
ABU89802      243 lglmhkdYLDEICQVTTKLq-kCNMTIEEVTLLRAITLTAGD------------RCDLENPAKVEEIQWKLISFLRsllk 309  Mediterranean...
P41828        461 eddaemqLIVEVNNTLQEIv-hLQPHQSELALLAAGLILEQVssshgigildtaTIATAETLKNALYQSVMPRIGC---- 535  Caenorhabditi...
XP_001901465  328 seqaelnFFLGMHSCIHELa-qLRLTNAEMGLLSAWILLDRSs----------lGQFVIEQFRNCLQQQIATRIAD---- 392  agent of lymp...
AAW88550     1727 nqfsvckILFEQINLTNKLlksLDLNETEIGLLCCVELFHTD------------GKYLNEPIKINEAYQTILQLLKeyet 1794 Schistosoma m...
AAR29356     1209 rhfptfkRITEHLRVSGRImhhLNLSLPELSLSCAAEILRNY------------CILEEPTAKSTAELFVLAHHSLlncm 1276 Schistosoma m...
P41830        370 -qllygsLADEMLAFANHIi-tIGCTDGDIALFIVLILCQPLt----------tEQQFSTNFKSQLQLLEMFDFYKkvlf 437  Caenorhabditi...
Feature 1                                      #                                                  
AAC77795      438 qkmtcridgcdTYKQLMKCIHELNRLNELHKQQLnilr------------------------------------------ 475  nematode
AAW88534     1455 -------slegRYAALSLISPMLEELNIEHHEVIaqlr------------------------------------------ 1485 Schistosoma m...
Q611B9        440 kklcshpngydIVFNFHKLVPALNGINNMLDEAFvkflr----------------------------------------- 478  Caenorhabditi...
ABS29716      443 ---------ecRAAAPQLLHTVLCELRMQNAVHQqsleaitiwpttccsssssvasnsddstnsntvktglsdsasrnie 513  dog heartworm...
AAR32910     1277 akh-svptvasTQQRRTQLFALRKMIRVMDKEHHgiladl---------------------------------------- 1315 Schistosoma m...
ABU89802      310 k------sydnPEQRLWQLFDIMTSLRNLESVAKnihal----------------------------------------- 342  Mediterranean...
P41828        536 -----------MEDTIHRIQDVETRIRQTARLHQealqnfr--------------------------------------- 565  Caenorhabditi...
XP_001901465  393 -----------SGPLMQKLCEIIQRLRGHAQEHIrllgqlft-------------------------------------- 423  agent of lymp...
AAW88550     1795 isl-sildqfnSEKRFYKIISIKHNLDRMNKEHQeiiki----------------------------------------- 1832 Schistosoma m...
AAR29356     1277 akh-svptvasTQQRRTQLFALRKMIRVMDKEHHgiladl---------------------------------------- 1315 Schistosoma m...
P41830        438 qkmtcridgcdTYKQLMKCIHELNRLNELHKQQLnilr------------------------------------------ 475  Caenorhabditi...
Feature 1                                                                                         
AAC77795          --------------------------------------------------------------------------------      nematode
AAW88534          --------------------------------------------------------------------------------      Schistosoma m...
Q611B9            --------------------------------------------------------------------------------      Caenorhabditi...
ABS29716      514 tellvlencgliqgqqqpeeplqelisplsvenrphddvqkrqtrssysqhrsennpeslqfssstlsrvqpsivethrs 593  dog heartworm...
AAR32910          --------------------------------------------------------------------------------      Schistosoma m...
ABU89802          --------------------------------------------------------------------------------      Mediterranean...
P41828            --------------------------------------------------------------------------------      Caenorhabditi...
XP_001901465      --------------------------------------------------------------------------------      agent of lymp...
AAW88550          --------------------------------------------------------------------------------      Schistosoma m...
AAR29356          --------------------------------------------------------------------------------      Schistosoma m...
P41830            --------------------------------------------------------------------------------      Caenorhabditi...
Feature 1                                          
AAC77795      476 --------------------enlsFLNLPPLVV 488  nematode
AAW88534     1486 --------------------qdrpDLEFPQLYL 1498 Schistosoma mansoni
Q611B9        479 --------------------dhkeSLSLPALFL 491  Caenorhabditis briggsae
ABS29716      594 vasllnqppilpiaiaairntfaqNCQLPTPML 626  dog heartworm nematode
AAR32910     1316 -------------------rvfrsDLRFPELYV 1329 Schistosoma mansoni
ABU89802      343 -------------------rskwaVMQDHPLVL 356  Mediterranean mussel
P41828        566 ------------------msdptsSEKLPALYK 580  Caenorhabditis elegans
XP_001901465  424 -----------------typqateKGALPDLYK 439  agent of lymphatic filariasis
AAW88550     1833 --------------------lkheNHYLPFSNL 1845 Schistosoma mansoni
AAR29356     1316 -------------------rvlrsDLRFPELYV 1329 Schistosoma mansoni
P41830        476 --------------------enlsFLNLPPLVV 488  Caenorhabditis elegans

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