Conserved Protein Domain Family
NR_LBD_DmE78_like

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cd06941: NR_LBD_DmE78_like 
The ligand binding domain of Drosophila ecdysone-induced protein 78, a member of the nuclear receptor superfamily.
The ligand binding domain (LBD) of Drosophila ecdysone-induced protein 78 (E78) like: Drosophila ecdysone-induced protein 78 (E78) is a transcription factor belonging to the nuclear receptor superfamily. E78 is a product of the ecdysone-inducible gene found in an early late puff locus at position 78C during the onset of Drosophila metamorphosis. Two isoforms of E78, E78A and E78B, are expressed from two nested transcription units. An E78 orthologue from the Platyhelminth Schistosoma mansoni (SmE78) has also been identified. It is the first E78 orthologue known outside of the molting animals--the Ecdysozoa. SmE78 may be involved in transduction of an ecdysone signal in S. mansoni, consistent with its function in Drosophila. Like other members of the nuclear receptor (NR) superfamily of ligand-activated transcription factors, E78-like receptors have a central well conserved DNA binding domain (DBD), a variable N-terminal domain, a non-conserved hinge and a C-terminal ligand binding domain (LBD).
Statistics
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PSSM-Id: 132739
View PSSM: cd06941
Aligned: 6 rows
Threshold Bit Score: 270.033
Threshold Setting Gi: 115682407
Created: 19-Nov-2008
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative ligandputative
Feature 1:putative ligand binding site [chemical binding site]
Evidence:
  • Comment:predicted based on homologous proteins.
  • Citation:PMID 9744270

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1              ##   #                                 #   #  #                        # # 
EEB13323      102 IWLWQQFASHVTPSVQRVVEFAKRVPGFcdLSQDDQLILIKVGFFEIWLGHVSRQTCds--------------smTFTDG 167  human body louse
XP_001200622  272 RNQWVQLAHILDQAVSGQVEFAKAIPGFrnLTQDDQLLLLKSSFFEMWVVRIAPLLMipsaphtnngmgplmaslTMDMH 351  purple urchin
AAR30507      506 LRMHEELSQLLAPCIQHVVEFAKRIPEFssLGQPDQLVLIKAAFFEVWLVQASRLIStnd------------rkiTLADG 573  Schistosoma m...
Q967S2        119 YQLWHSLNEAMFEDLGRFIEFTKRIPGFvnISHKDQLLAVKTAFFEVWLVWISHTMNskt------------gtiTFSHG 186  dog heartworm...
XP_797496     195 CTVKGYLTDVLTPSVVNVVQFSKNLPGFcdLLQEDQMTLLKAGFFEIWLLRTCMEIAftsd----------svsfGTDHG 264  purple urchin
P45447        663 IWLWQQFSARVTPGVQRIVEFAKRVPGFcdFTQDDQLILIKLGFFEVWLTHVARLINea--------------tlTLDDG 728  fruit fly
Feature 1                                     #                                                   
EEB13323      168 tyitkqqm------------dliydpeFVSSLFHFAASFnaLALNDTELGLFSAVVLLSADrp-gVADIKVIEQHQDRLI 234  human body louse
XP_001200622  352 hspssgvngmgtgsllwqqlyhvfgsdLYHAMHQFSQEFnqLGLLETEVALYASSLLAANDim-gLSNPQAVAELQHQLV 430  purple urchin
AAR30507      574 kqitkqel------------dfiyspsVVCSIFSFSENFnsLVLNDTEVALCCAAVITKPNry-gLIEPNKVAIIQDHHL 640  Schistosoma m...
Q967S2        187 isfsreql------------siiygvvLIKQMFEFGDRFmsYKLSESLLGLYCAVLLLTQDnipkLEKPHKMLILRERVM 254  dog heartworm...
XP_797496     265 yamshls-------------mlgcdyrFWDELFDFSRSFnnLQLIKEEIALFTTVVLFSPDrh-gLVEPGKVEVLQDRYL 330  purple urchin
P45447        729 ayltrqql------------eilydsdFVNALLNFANTLnaYGLSDTEIGLFSAMVLLASDra-gLSEPKVIGRARELVA 795  fruit fly
Feature 1                                              #                           
EEB13323      235 EALKVQVgrnha---sdpqLFSSLLMKLPELRNLGAKHSAHLDWFRINWql--lrLPPLFAEIFD 294  human body louse
XP_001200622  431 EALQVQVdgnhp--saaapLMATLYGRVQELRRIGGMHRDFVMGCSQRWpdlcpgLPALYTEMMD 493  purple urchin
AAR30507      641 AALRMQLernrp---reatLIGQVRNVINQVTTVGDEVQLCIRWYRENWyr--trLAPLYAETYD 700  Schistosoma mansoni
Q967S2        255 YALKLQLsterp---aeseLFHSLLVKRELLRSIAIRHQMALDWYRVHLdl--irLPQIFVDLYD 314  dog heartworm nematode
XP_797496     331 ECLKREVtrrdw---knkqLFARLLMQATNLRAVSAIFFKSTSEFRHAWpy--meIPALLQEILN 390  purple urchin
P45447        796 EALRVQIlrsragspqalqLMPALEAKIPELRSLGAKHFSHLDWLRMNWtk--lrLPPLFAEIFD 858  fruit fly

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