3CQV,2V0V,2V7C


Conserved Protein Domain Family
NR_LBD_REV_ERB

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cd06940: NR_LBD_REV_ERB 
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The ligand binding domain of REV-ERB receptors, members of the nuclear receptor superfamily
The ligand binding domain (LBD) of REV-ERB receptors: REV-ERBs are transcriptional regulators belonging to the nuclear receptor superfamily. They regulate a number of physiological functions including the circadian rhythm, lipid metabolism, and cellular differentiation. The LBD domain of REV-ERB is unusual in the nuclear receptor family by lacking the AF-2 region that is responsible for coactivator interaction. REV-ERBs act as constitutive repressors because of their inability to bind coactivators. REV-ERB receptors can bind to two classes of DNA response elements as either a monomer or heterodimer, indicating functional diversity. When bound to the DNA, they recruit corepressors (NcoR/histone deacetylase 3) to the promoter, resulting in repression of the target gene. The porphyrin heme has been demonstrated to function as a ligand for REV-ERB. Like other members of the nuclear receptor (NR) superfamily of ligand-activated transcription factors, REV-ERB receptors have a central well conserved DNA binding domain (DBD), a variable N-terminal domain, a non-conserved hinge and a C-terminal ligand binding domain (LBD).
Statistics
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PSSM-Id: 132738
View PSSM: cd06940
Aligned: 9 rows
Threshold Bit Score: 314.815
Threshold Setting Gi: 148226871
Created: 19-Nov-2008
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
ligand bindinghomodimer
Conserved site includes 16 residues -Click on image for an interactive view with Cn3D
Feature 1:ligand binding site [chemical binding site]
Evidence:
  • Structure:1CQV_a; human Reverb Beta In Complex With Heme, contacts at 4A
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                         #  #   #   #                             #  ##  #   #           
3CQV_A          9 SPYVDPHks---gHEIWEEFSXSFTPAVKEVVEFAKRIPGFrDLSQHDQVNLLKAGTFEVLXVRFASLFDAKERTVTFLS 85   human
NP_001073579  219 CPLNPNPqpltgqQELLQDFSKRFSPAIRGVVEFAKRIPGFsLLAQDDQVTLLKAGVFEVLLVRLACMFDAQTNSMICLN 298  honey bee
P13055        609 CPLNPAPe-----LQSEQEFSQRFAHVIRGVIDFAGMIPGFqLLTQDDKFTLLKAGLFDALFVRLICMFDSSINSIICLN 683  fruit fly
AAK76396      402 SPYVDPQks---gHSIWEEFSMSFTPAVREVVEFAKRIPGFkDLSQHDQVSLLKAGTFEVLVVRFTSLFDVKERKVTFLS 478  zebrafish
NP_001085940  328 LHQGGPVrs---vQEVWEHFSLSFTPAVREVVEFARHIPGFnDLTQNDQVTLLKAGTFEVLMVRFASLFDARERSLRFLS 404  African clawe...
NP_990536     359 TPHVDPNks---gHEVWEEFSLSFTPAVKEVVEFAKRIPGFrDLSQHDQVNLLKAGTFEVLMVRFASLFDARERTVTFLS 435  chicken
2V0V_A          4 SPYVDPHks---gHEIWEEFSMSFTPAVKEVVEFAKRIPGFrDLSQHDQVNLLKAGTFEVLMVRFASLFDAKERTVTFLG 80   human
2V7C_A          4 SPYVDPHks---gHEIWEEFSXSFTPAVKEVVEFAKRIPGFrDLSQHDQVNLLKAGTFEVLXVRFASLFDAKERTVTFLS 80   human
BAG36250      389 SPYVDPHks---gHEIWEEFSMSFTPAVKEVVEFAKRIPGFrDLSQHDQVNLLKAGTFEVLMVRFASLFDAKERTVTFLS 465  human
Feature 1                          ##  #                                                          
3CQV_A         86 GKKYsvddlh-sxgagDLLNSXFEFSEKLnaLQLSDEEXSLFTAVVLVSADRSGIENVNSVEALQETLIRALRTLIXKNH 164  human
NP_001073579  299 GQVLkresihnssnarFLMDSMFDFAERVnsLRLSDAELGLFCSVVVIAADRPGLRNTELVERMHNKLRNALQTVLAQNH 378  honey bee
P13055        684 GQVMrrdaiqnganarFLVDSTFNFAERMnsMNLTDAEIGLFCAIVLITPDRPGLRNLELIEKMYSRLKGCLQYIVAQNR 763  fruit fly
AAK76396      479 GRKYsvdalr-slgagDLLNSMFDFTEKLqaLNLSEEEMSLFTAVVLVSADRSGLENVNSVEALQETLIRALRSLITKNH 557  zebrafish
NP_001085940  405 GATYslpelh-amgmgELLGSMFDFSEKLssLSLSQEELGIFTALVLVSADRSGMENSSLVEQLQETLIRALRSLILKNS 483  African clawe...
NP_990536     436 GKKYsvddlh-smgagDLLNSMFEFSEKLnaLQLSDEEMSLFTAVVLVSADRSGIENVNSVEALQETLIRALRTLIMKNH 514  chicken
2V0V_A         81 SKKYsvddlh-smgagDLLNSMFEFSEKLnaLQLSDEEMSLFTAVVLVSADRSGIENVNSVEALQETLIRALRTLIMKNH 159  human
2V7C_A         81 GKKYsvddlh-sxgagDLLNSXFEFSEKLnaLQLSDEEXSLFTAVVLVSADRSGIENVNSVEALQETLIRALRTLIXKNH 159  human
BAG36250      466 GKKYsvddlh-smgagDLLNSMFEFSEKLnaLQLSDEEMSLFTAVVLVSADRSGIENVNSVEALQETLIRALRTLIMKNH 544  human
Feature 1                                #  ##  #  
3CQV_A        165 PNeasIFTKLLLKLPDLRSLNNXHSEELLAFKV 197  human
NP_001073579  379 PQhpdILRELLKKIPDLRTLNTLHSEKLLAFKM 411  honey bee
P13055        764 PDqpeFLAKLLETMPDLRTLSTLHTEKLVVFRT 796  fruit fly
AAK76396      558 PNeiaIFTKLLLKLPDLRSLNNMHSEQLLAFKV 590  zebrafish
NP_001085940  484 PNdtsRFTKLLLRLPDLRTLNNLHSEKLLSFRV 516  African clawed frog
NP_990536     515 PNeasIFTKLLLKLPDLRSLNNMHSEELLAFKV 547  chicken
2V0V_A        160 PNeasIFTKLLLKLPDLRSLNNMHSEELLAFKV 192  human
2V7C_A        160 PNeasIFTKLLLKLPDLRSLNNXHSEELLAFKV 192  human
BAG36250      545 PNeasIFTKLLLKLPDLRSLNNMHSEELLAFKV 577  human

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