2NXX,1R20,1Z5X,1R1K


Conserved Protein Domain Family
NR_LBD_EcR

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cd06938: NR_LBD_EcR 
Click on image for an interactive view with Cn3D
The ligand binding domain (LBD) of the Ecdysone receptor, a member of the nuclear receptors super family
The ligand binding domain (LBD) of the ecdysone receptor: The ecdysone receptor (EcR) belongs to the superfamily of nuclear receptors (NRs) of ligand-dependent transcription factors. Ecdysone receptor is present only in invertebrates and regulates the expression of a large number of genes during development and reproduction. ECR functions as a heterodimer by partnering with ultraspiracle protein (USP), the ortholog of the vertebrate retinoid X receptor (RXR). The natural ligands of ecdysone receptor are ecdysteroids#the endogenous steroidal hormones found in invertebrates. In addition, insecticide bisacylhydrazine used against pests has shown to act on EcR. EcR must be dimerised with a USP for high-affinity ligand binding to occur. The ligand binding triggers a conformational change in the C-terminal part of the EcR ligand-binding domain that leads to transcriptional activation of genes controlled by EcR. Like other members of the nuclear receptor (NR) superfamily of ligand-activated transcription factors, ec dysone receptors have a central well conserved DNA binding domain (DBD), a variable N-terminal domain, a non-conserved hinge and a C-terminal ligand binding domain (LBD).
Statistics
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PSSM-Id: 132736
View PSSM: cd06938
Aligned: 10 rows
Threshold Bit Score: 361.369
Threshold Setting Gi: 146400031
Created: 19-Nov-2008
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
ligand bindingputativeheterodimer
Conserved site includes 18 residues -Click on image for an interactive view with Cn3D
Feature 1:ligand binding site [chemical binding site]
Evidence:
  • Structure:2NXX_e; Tribolium castaneum ligand-binding domain binds ponasterone A, contacts at 4A
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                    ###                              ## ##  #                        
2NXX_E     14 QEELIHRLVYFQNEYEHPSEeDVKRIinqpmd-----gedqcDVRFRHITEITILTVQLIVEFAKRLPGFdKLLREDQIA 88  red flour beetle
O44336    212 QEDLINKLVYYQQEFESPSEeDMKKTtpfplg----dseednQRRFQHITEITILTVQLIVEFSKRVPGFdTLAREDQIT 287 lone star tick
ABQ28713  325 TRELINRIVTIDQQFATPSTdMLMKVseh----------nevGNSYQQLAELTILSLQLIHQFTMHLPGFcKLSDEDKRT 394 agent of lymphatic...
AAC33432  286 QEELINTLVYYQEEFEQPTEaDVKKIrfnfd------gedtsDMRFRHITEMTILTVQLIVEFSKQLPGFaTLQREDQIT 359 Atlantic sand fidd...
ABN11289   71 QKELIHRLVYFQDQYEAPSEkDMKRLtinnqnmdeydeekqsDTTYRIITEMTILTVQLIVEFAKRLPGFdKLVREDQIT 150 green peach aphid
P49880    438 QMAVIYKLIWYQDGYEQPSEeDLKRImigspn----eeedqhDVHFRHITEITILTVQLIVEFAKGLPAFtKIPQEDQIT 513 yellow fever mosquito
BAF75375  264 QEELISALVHYQEEFEQPSEaDIKRIqeigit-----dddseDPKFEHITKMTILTVELIIEFSKRLTGFgDLLREDQIT 338 Marsupenaeus japon...
1R20_D     27 QKSLIARLVYYQEGYEQPSEeDLKRVtqtwqsd---eddedsDMPFRQITEMTILTVQLIVEFAKGLPGFsKISQSDQIT 103 tobacco budworm
1Z5X_E     78 QEELIHRLVYFQNEYEHPSPeDIKRIvnaape-----eenvaEERFRHITEITILTVQLIVEFSKRLPGFdKLIREDQIA 152 sweet potato whitefly
1R1K_D     28 QKSLIARLVWYQEGYEQPSEeDLKRVtqtwqsd---eddedsDMPFRQITEMTILTVQLIVEFAKGLPGFaKISQSDQIT 104 tobacco budworm
Feature 1              #  ##  #       # ##            #           #                           
2NXX_E     89 LLKACSSEVMMFRMARRYDvqtDSILFVNNQPYSr---dSYNLAGmgeTIEDLLHFCRTMysMRVDNAEYALLTAIVIFS 165 red flour beetle
O44336    288 LLKACSSEVMMLRGARKYDvktDSIVFANNQPYTr---dNYRSASvgdSADALFRFCRKMcqLRVDNAEYALLTAIVIFS 364 lone star tick
ABQ28713  395 LHKTCKTEVLVLRTSRCYDmfdEKVVLGNEAKQWrydreQYREFIg-pLADLMFDFAHALskMQLHQAEYVLLTAIAIFS 473 agent of lymphatic...
AAC33432  360 LLKACSSEVMMLRAARRYDaktDSIVFGNNYPYTq---aSYALAGlgeSAEILFRFCRSLckMKVDNAEYALLAAIAIFS 436 Atlantic sand fidd...
ABN11289  151 LLKACSSEAMMFRVARKYDittDSIVFANNQPFSa---dSYNKAGlgdAIENQLSFSRFMynMKVDNAEYALLTAIVIFS 227 green peach aphid
P49880    514 LLKACSSEVMMLRMARRYDaatDSILFANNRSYTr---dSYRMAGmadTIEDLLHFCRQMfsLTVDNVEYALLTAIVIFS 590 yellow fever mosquito
BAF75375  339 LLKACSSEVMMLRAARRYDaktNSIVFGNSYPYTe---sEYETAGlgfSAPMLFRFCRNMcrMKVDNAEYALLAAMSIFS 415 Marsupenaeus japon...
1R20_D    104 LLKACSSEVMMLRVARRYDaatDSVLFANNQAYTr---dNYRKAGmayVIEDLLHFCRCMysMMMDNVHYALLTAIVIFS 180 tobacco budworm
1Z5X_E    153 LLKACSSEVMMFRMARRYDaetDSILFATNQPYTr---eSYTVAGmgdTVEDLLRFCRHMcaMKVDNAEYALLTAIVIFS 229 sweet potato whitefly
1R1K_D    105 LLKACSSEVMMLRVARRYDaatDSVLFANNQAYTr---dNYRKAGmayVIEDLLHFCRCMysMMMDNVHYALLTAIVIFS 181 tobacco budworm
Feature 1                                                                 #                   
2NXX_E    166 ERp-aLIEGWKVEKIQEIYLEALRAYVDNRrkpk--pgtIFAKLLSVLTELRTLGNQNSEMCFSLklk-nkKLPPFLAEI 241 red flour beetle
O44336    365 ERp-sLVDPHKVERIQEYYIETLRMYSENHrpp---gknYFARLLSILTELRTLGNMNAEMCFSLkvq-nkKLPPFLAEI 439 lone star tick
ABQ28713  474 DRp-gLLQPKSVEDIQEVYTSALQSYVDALrpk---qrnIFSRLLMKLTDLRSLTSEQSEIITGIsstsiaIKPSSSQQS 549 agent of lymphatic...
AAC33432  437 ERp-nLKELKKVEKLQEIYLEALKSYVENRrlpr--snmVFAKLLNILTELRTLGNINSEMCFSLtlk-nkRLPPFLAEI 512 Atlantic sand fidd...
ABN11289  228 SRp-nLLDGWKVEKIQEIYLESLKAYVDNRdrdt--atvRYARLLSVLTELRTLGNENSELCMTLklk-nrVVPPFLAEI 303 green peach aphid
P49880    591 DRp-gLEQAELVEHIQSYYIDTLRIYILNRhagdpkcsvIFAKLLSILTELRTLGNQNSEMCFSLklk-nrKLPRFLEEI 668 yellow fever mosquito
BAF75375  416 ADrpfLREAYKVQKLQEIYLNALSAYVANKravn-sfsvMIGKLLNVLTELRTLGNLNSEMCYRIqlt-dkRLPDLLNEI 493 Marsupenaeus japon...
1R20_D    181 DRp-gLEQPSLVEEIQRYYLNTLRVYILNQnsasprsavIFGKILGILTEIRTLGMQNSNMCISLklk-nrKLPPFLEEI 258 tobacco budworm
1Z5X_E    230 ERp-sLSEGWKVEKIQEIYIEALKAYVENRrkpy--attIFAKLLSVLTELRTLGNMNSETCFSLklk-nrKVPSFLEEI 305 sweet potato whitefly
1R1K_D    182 DRp-gLEQPLLVEEIQRYYLNTLRVYILNQnsasprcavIFGKILGILTEIRTLGMQNSNMCISLklk-nrKLPPFLEEI 259 tobacco budworm
Feature 1        
2NXX_E    242 WDV 244 red flour beetle
O44336    440 WDI 442 lone star tick
ABQ28713  550 CDV 552 agent of lymphatic filariasis
AAC33432  513 WDV 515 Atlantic sand fiddler crab
ABN11289  304 WDV 306 green peach aphid
P49880    669 WDV 671 yellow fever mosquito
BAF75375  494 WDV 496 Marsupenaeus japonicus
1R20_D    259 WDV 261 tobacco budworm
1Z5X_E    306 WDV 308 sweet potato whitefly
1R1K_D    260 WDV 262 tobacco budworm

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