3BEJ,1OSV,1OT7


Conserved Protein Domain Family
NR_LBD_Fxr

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cd06936: NR_LBD_Fxr 
Click on image for an interactive view with Cn3D
The ligand binding domain of Farnesoid X receptor:a member of the nuclear receptor superfamily of ligand-activated transcription factors.
The ligand binding domain (LBD) of Farnesoid X receptor: Farnesoid X receptor (FXR) is a member of the nuclear receptor superfamily of ligand-activated transcription factors. FXR is highly expressed in the liver, the intestine, the kidney, and the adrenals. FXR plays key roles in the regulation of bile acid, cholesterol, triglyceride, and glucose metabolism. Evidences show that it also regulates liver regeneration. Upon binding of ligands, such as bile acid, an endogenous ligand, FXRs bind to FXR response elements (FXREs) either as a monomer or as a heterodimer with retinoid X receptor (RXR), and regulate the expression of various genes involved in bile acid, lipid, and glucose metabolism. There are two FXR genes (FXRalpha and FXRbeta) in mammals. A single FXRalpha gene encodes four isoforms resulting from differential use of promoters and alternative splicing. FXRbeta is a functional receptor in mice, rats, rabbits and dogs, but is a pseudogene in humans and primates. Like other members of the nuclear receptor (NR) superfamily, farnesoid X receptors have a central well conserved DNA binding domain (DBD), a variable N-terminal domain, a non-conserved hinge and a C-terminal ligand binding domain (LBD).
Statistics
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PSSM-Id: 132734
View PSSM: cd06936
Aligned: 7 rows
Threshold Bit Score: 369.543
Threshold Setting Gi: 82213639
Created: 19-Nov-2008
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 14 residues -Click on image for an interactive view with Cn3D
Feature 1:ligand binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                       #                  #  ## ##  #                                
3BEJ_A     13 PDQQTLLHFIMDSYNKQRMpqeitnkilkeefsaEENFLILTEMATNHVQVLVEFTKKLPGFqtLDHEDQIALLKGSAVE 92  human
Q8JHU2    248 PEQQNLLDYIMDSYSKQQIpqevskkllheefsaEGNFLILTEMATSHVQVLVEFTKKLPGFqtLDHEDQIALLKGSAVE 327 chicken
Q8JJ27    255 GEEYKLIDHIVTAHQKCGIslddmkmfleesadpEEIFYHFSEAAVLHVRAFVEFTKSLPGFemLDPLDQIALLKASTVE 334 African clawed frog
Q811X2    247 QEEHRLLNTIVTAHQKSMIplgetskllqegsnpELSFLRLSEVSVLHIQGLMKFTKGLPGFenLTTEDQAALQKASKTE 326 house mouse
Q4S7G0    238 TEQQALMRVITDAYNKHQIpqdvtkkllqdqystEENFLLLTEMATSQVQVLVEFTKNIPGFlsLDREDQIALLKGSAVE 317 Tetraodon nigrovir...
1OSV_A      5 VDQQTLLDYIMDSYSKQRMpqeitnkilkeefsaEENFLILTEMATSHVQILVEFTKRLPGFqtLDHEDQIALLKGSAVE 84  Norway rat
1OT7_A      5 VDQQTLLDYIMDSYSKQRMpqeitnkilkeefsaEENFLILTEMATSHVQILVEFTKRLPGFqtLDHEDQIALLKGSAVE 84  Norway rat
Feature 1      ## ##  #                                                                       
3BEJ_A     93 AMFLRSAEIFNk------------------------------KLPSGh--SDLLEERIRNsgi----------------- 123 human
Q8JHU2    328 AMFLRSAEIFSr------------------------------KLPTGh--TVLLEERIRNsgi----------------- 358 chicken
Q8JJ27    335 AMLLRSAQIYNqsvmgstlqtteglarypshsvdfsqiqefdKCPLYsleAHPQEEDSTSstdl---------------- 398 African clawed frog
Q811X2    327 VMFLHVAQLYGt------------------------------MRPAKp-sAGTLEVHNPSadesvhspenflkegypsap 375 house mouse
Q4S7G0    318 AMFLRSAQALNk------------------------------KMPIGh--TEVLEERIHKsgi----------------- 348 Tetraodon nigrovir...
1OSV_A     85 AMFLRSAEIFNk------------------------------KLPAGh--ADLLEERIRKsgi----------------- 115 Norway rat
1OT7_A     85 AMFLRSAEIFNk------------------------------KLPAGh--ADLLEERIRKsgi----------------- 115 Norway rat
Feature 1                                                                                     
3BEJ_A    124 ----sdeYITPMFSFYKSIgeLKMTQEEYALLTAIVILSPDRqyIKDREAVEKLQEPLLDVLQKLCkihqPENPQHFACL 199 human
Q8JHU2    359 ----sdeFITPMFNFYKSIgeLKMTQEEYALLTAIVILSPDRqyIKDRESVERLQEPLLDILQKFCklhhPDNPQHFACL 434 chicken
Q8JJ27    399 ----teeFITPLFNFFRSMgsLNVTEAEYALLSAVTVYFSDRplLQSKPHVEKLQEPLLGILHKYSrlyhPEDPQHFARL 474 African clawed frog
Q811X2    376 ltditkeFIASLSYFYRRMseLHVSDTEYALLTATTVLFSDRpcLKNKQHIENLQEPVLQLLFKFSkmyhPEDPQHFAHL 455 house mouse
Q4S7G0    349 ----seeFIKPMFNFYKSIgeLHMVLEEQALLTTITILTPDRpyVKDQPAVERLQENVLDLLRKMCvlhhPQEPQYFARL 424 Tetraodon nigrovir...
1OSV_A    116 ----sdeYITPMFSFYKSVgeLKMTQEEYALLTAIVILSPDRqyIKDREAVEKLQEPLLDVLQKLCkiyqPENPQHFACL 191 Norway rat
1OT7_A    116 ----sdeYITPMFSFYKSVgeLKMTQEEYALLTAIVILSPDRqyIKDREAVEKLQEPLLDVLQKLCkiyqPENPQHFACL 191 Norway rat
Feature 1                  #             #      
3BEJ_A    200 LGRLTELRTFNHHHAEMLMSWRvndhkFTPLLCE 233 human
Q8JHU2    435 LGRLTELRTFNHHHAEMLMSWRvndhkFTPLLCE 468 chicken
Q8JJ27    475 IGRLTELRTLHHNHSEVLVLWKardtkLTPFAVW 508 African clawed frog
Q811X2    456 IGRLTELRTLSHSHSEILRMWKtkdprLVMLFSE 489 house mouse
Q4S7G0    425 LGRLTELRTLSHYHAEMLASWKvnnhkFTPLLCE 458 Tetraodon nigroviridis
1OSV_A    192 LGRLTELRTFNHHHAEMLMSWRvndhkFTPLLCE 225 Norway rat
1OT7_A    192 LGRLTELRTFNHHHAEMLMSWRvndhkFTPLLCE 225 Norway rat

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