1XV9,1ILG


Conserved Protein Domain Family
NR_LBD_PXR_like

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cd06934: NR_LBD_PXR_like 
Click on image for an interactive view with Cn3D
The ligand binding domain of xenobiotic receptors:pregnane X receptor and constitutive androstane receptor
The ligand binding domain of xenobiotic receptors: This xenobiotic receptor family includes pregnane X receptor (PXR), constitutive androstane receptor (CAR) and other related nuclear receptors. They function as sensors of toxic byproducts of cell metabolism and of exogenous chemicals, to facilitate their elimination. The nuclear receptor pregnane X receptor (PXR) is a ligand-regulated transcription factor that responds to a diverse array of chemically distinct ligands, including many endogenous compounds and clinical drugs. The ligand binding domain of PXR shows remarkable flexibility to accommodate both large and small molecules. PXR functions as a heterodimer with retinoic X receptor-alpha (RXRa) and binds to a variety of response elements in the promoter regions of a diverse set of target genes involved in the metabolism, transport, and elimination of these molecules from the cell. Constitutive androstane receptor (CAR) is a closest mammalian relative of PXR, which has also been proposed to function as a xenosensor. CAR is activated by some of the same ligands as PXR and regulates a subset of common genes. The sequence homology and functional similarity suggests that the CAR gene arose from a duplication of an ancestral PXR gene. Like other nuclear receptors, xenobiotic receptors have a central well conserved DNA binding domain (DBD), a variable N-terminal domain, a flexible hinge and a C-terminal ligand binding domain (LBD).
Statistics
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PSSM-Id: 132732
View PSSM: cd06934
Aligned: 7 rows
Threshold Bit Score: 361.353
Threshold Setting Gi: 61679484
Created: 1-Dec-2008
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 16 residues -Click on image for an interactive view with Cn3D
Feature 1:ligand binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                        
1XV9_B         4 LSKEQEELIRTLLGAHTRHMGtmFEQFVQFRPPahlfihhq--------------------------------------- 44  human
Q8QGH6        32 LTPQQEAVIQELLNAHKKTFDmtCAHFSQFRPLdrdqksvsesspltngswidhrpiaedpmq----------------- 94  zebrafish
Q4S0H1       100 LSSQQEETIRELVCSHRKTFDpaFYRFTLFHRPkvrvgfssgfsqpmdrniftvgdssrsgdapsav------------- 166 Tetraodon nigro...
NP_001118144 126 LSPQQEAVIQELFNAHEKTFDi-TFSHFQFRPIdrdlnpmsvwnqtaseqsvkqtrrmdnlsssystststsfsssscsl 204 rainbow trout
1ILG_A        25 LTEEQRMMIRELMDAQMKTFDttFSHFKNFRLPgvlssgcelpeslqapsreeaakwsqvrkdl---------------- 88  human
Q9DFH3       127 LTAEQQELISILIAAHKRTFDssFSQFQHYQPAvrlcipgpcsqsppgpgvp---------------------------- 178 chicken
CAA53006     138 LTPEQQHFLTQLVGAHTKTFDfnFTFSKNFRPIrrssdptqe-------------------------------------- 179 African clawed ...
Feature 1                                                                ##  ##  #               
1XV9_B        45 -------------------------------------------plptlapvLPLVTHFADINTFMVLQVIKFTKDLPVFR 81  human
Q8QGH6        95 ---------------------wvfnptslssssssyqsldnkekkhfksgnFSSLPHFTDLTTYMIKNVINFGKTLTMFR 153 zebrafish
Q4S0H1       167 ------------------gplspscsslpsvpprgetqqsregeearragvFTALPHVTDLTTYMIHDIIAFSKSLTHFK 228 Tetraodon nigro...
NP_001118144 205 edeekedrsggkntvfttlpdvadlttnmeekkeeekekkedrsdggkntvFTTLPHIADLTTYMIQNIINFAKGLPSFR 284 rainbow trout
1ILG_A        89 ---------------------cslkvslqlrgedgsvwnykppadsggkeiFSLLPHMADMSTYMFKGIISFAKVISYFR 147 human
Q9DFH3       179 --------------------------------saslspqldcldedvlpdvFSILPHFADLSTFMIQQVIKFAKEIPAFR 226 chicken
CAA53006     180 -------------------------------------------pqatsseaFLMLPHISDLVTYMIKGIISFAKMLPYFK 216 African clawed ...
Feature 1                           #  #          #      #   ##    #   ##  #                     
1XV9_B        82 sLPIEDQISLLKGAAVEICHIVLNTTFCLQTQNFLCGPLRYtieDGARVGFQVEFLELLFHFHGTLRKLQLQEPEYVLLA 161 human
Q8QGH6       154 aLVMEDQISLLKGATFEIILIHFNMFFNEVTGIWECGPLQYcmdDAFRAGFQHHLLDPMMNFHYTLRKLRLHEEEYVLMQ 233 zebrafish
Q4S0H1       229 sLLIGDQMALLKGATFEVMEIRFNMVFNTKTGVWECGHATYcieDAVRAGFQPLLLEPLLRFHHTLRNLGLEEEEYVLMQ 308 Tetraodon nigro...
NP_001118144 285 aLAIDDQISLLKGAMFEMMQIRFNMMFNVKTGIWECGPLTYcmdDAVRAGFQRHLLDPLMRFHYTLRNLQLQEVEYVLMQ 364 rainbow trout
1ILG_A       148 dLPIEDQISLLKGAAFELCQLRFNTVFNAETGTWECGRLSYc-lEDTAGGFQQLLLEPMLKFHYMLKKLQLHEEEYVLMQ 226 human
Q9DFH3       227 gLPIDDQISLLKGATLGICQIQFNTVFNEETNAWECGQHCFtikDGALAGFQQIYLEPLLKFHISLKKLRLHEAEYVLLV 306 chicken
CAA53006     217 sLDIEDQIALLKGSVAEVSVIRFNTVFNSDTNTWECGPFTYdteDMFLAGFRQLFLEPLVRIHRMMRKLNLQSEEYAMMA 296 African clawed ...
Feature 1                                                                                        
1XV9_B       162 AMALFSPDRp------------------------------GVTQRDEIDQLQEEMALTLQSYIKGqqrr-prdrFLYAKL 210 human
Q8QGH6       234 ALSLFSPDRp------------------------------GVTDHKVIDRNQETLALTLKTYIEAkrng-pekhLLFPKI 282 zebrafish
Q4S0H1       309 AMSLFSPGRtrsaplvsdgpqgwfvstplqsvcfklsdrsGVQEHGVIDRIHENMALTLKTRIDSkrtg-pekrMLYPKV 387 Tetraodon nigro...
NP_001118144 365 AISLFSPDRp------------------------------GVINHGVIDSLQEKLAIALKVHIDSkrak-pekhLLYPKI 413 rainbow trout
1ILG_A       227 AISLFSPDRp------------------------------GVLQHRVVDQLQEQFAITLKSYIECnrpq-pahrFLFLKI 275 human
Q9DFH3       307 AMLLFSPDHa------------------------------SVTQRDFIDQLQEKVALTLKSYIDHrhpm-pegrFLYAKL 355 chicken
CAA53006     297 ALSIFASDRp------------------------------GVCDWEKIQKLQEHIALTLKDFIDSqrppspqnrLLYPKI 346 African clawed ...
Feature 1                     #                       
1XV9_B       211 LGLLAELRSINEAYGYQIQHIQGLSAm---MPLLQEI 244 human
Q8QGH6       283 MGCLTEMRSMNEEYTKQVLKIQDMQPe--vSPLWLEI 317 zebrafish
Q4S0H1       388 LACLTEMRTLTQEYSKQILQIQDIQPnv-mPPLMVEM 423 Tetraodon nigroviridis
NP_001118144 414 LACLTEMRTMNEEYTKQVLQIQDIQPgnsfDPLILEV 450 rainbow trout
1ILG_A       276 MAMLTELRSINAQHTQRLLRIQDIHPf--aTPLMQEL 310 human
Q9DFH3       356 LLLLTELQTLKMENTRQILHIQDLSSm---TPLLSEI 389 chicken
CAA53006     347 MECLTELRTVNDIHSKQLLEIWDIQPd--aTPLMREV 381 African clawed frog

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