1FM6,2J14


Conserved Protein Domain Family
NR_LBD_PPAR

?
cd06932: NR_LBD_PPAR 
Click on image for an interactive view with Cn3D
The ligand binding domain of peroxisome proliferator-activated receptors
The ligand binding domain (LBD) of peroxisome proliferator-activated receptors (PPAR): Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear receptor superfamily of ligand-activated transcription factors. PPARs play important roles in regulating cellular differentiation, development and lipid metabolism. Activated PPAR forms a heterodimer with the retinoid X receptor (RXR) that binds to the hormone response element located upstream of the peroxisome proliferator responsive genes and interacts with co-activators. There are three subtypes of peroxisome proliferator activated receptors, alpha, beta (or delta), and gamma, each with a distinct tissue distribution. Several essential fatty acids, oxidized lipids and prostaglandin J derivatives can bind and activate PPAR. Like other members of the nuclear receptor (NR) superfamily of ligand-activated transcription factors, PPAR has a central well conserved DNA binding domain (DBD), a variable N-terminal regulatory domain, a flexible hinge a nd a C-terminal ligand binding domain (LBD).
Statistics
?
PSSM-Id: 132730
View PSSM: cd06932
Aligned: 9 rows
Threshold Bit Score: 302.023
Threshold Setting Gi: 72164991
Created: 19-Nov-2008
Updated: 2-Oct-2020
Structure
?
Program:
Drawing:
Aligned Rows:
 
Conserved site includes 10 residues -Click on image for an interactive view with Cn3D
Feature 1:ligand binding site [chemical binding site]
Evidence:

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                        
1FM6_D         4 ADLRALAKHLYDSYIKsfpltkaKARAILTGKttdkspfviydmnslmmge----------------------------- 54  human
2J14_A        17 ADLKAFSKHIYNAYLKnfnmtkkKARSILTGKashtapfvihdietlwqae----------------------------- 67  human
NP_001001460 207 ADLRALAKHLYDSYIKsfpltkaKARAILTGKttdkspfviydmnslrmge----------------------------- 257 chicken
Q7T029       230 ADLRALARHLYEAYLKyfpltkaKARAILSGKtgdnapfvihdikslmegeqfincrqmpiqeqqqas------------ 297 plaice
Q4H2X4       176 TKLVSPCDEMLTPDLKarllfasQVFKKNIGKdkptiykn---------------------------------------- 215 Ciona intestinalis
P37233       129 SDLDVLSQLIHSSYMNtftmtkkRARDILTGRnsispfvihdmdtlwqaeq----------------------------- 179 African clawed ...
XP_781750    137 RIHSIYINMWMGQFISmpvgsraTRSKEPNGKtedhksm----------------------------------------- 175 purple urchin
XP_784429    219 VDSIAQQFNDIVCAMTqed--leKFWKRCSRPftahmpsgtyviegm--------------------------------- 263 purple urchin
AAL26245      95 SDLRSLARLVQEAYLRifplskaKAQAILAGKvqnnavvihdheslaqaedtilqksgygtihnhgsigvniasvgggcg 174 sea lamprey
Feature 1                                                                            ##   #      
1FM6_D        55 --------------------------------------------dkikfkhitplqeqskevaIRIFQGCQFRSVEAVQE 90  human
2J14_A        68 --------------------------------------------kglvwkqlvnglppykeisVHVFYRCQCTTVETVRE 103 human
NP_001001460 258 --------------------------------------------dqikckhasplqeqnkevaIRIFQRCQFRSVEAVQE 293 chicken
Q7T029       298 ---------------------------vltathggltehhmgsdygvwgttsisgqepqnaleLRFFQSCQSRSAEAVRE 350 plaice
Q4H2X4       216 --------------------------------------------------------vigskivQILYSDFQARVVNGICE 239 Ciona intestinalis
P37233       180 ---------------------------------------------gtvweqlptqnltgteigVHVFYRCQCTSVETVRA 214 African clawed ...
XP_781750    176 ---------------------------------------------------------keltekEALTKFCRGALLAIIES 198 purple urchin
XP_784429    264 -------------------------------------------------qlnkdgppqeitsrAEMAQQCFVSMEVTIEK 294 purple urchin
AAL26245     175 garggticdgrggpcdsttrgrvlgtdcvfitansvtdtelaadaegnrssdqevtpprgaaeIRIFNRCHYRLVEAVRE 254 sea lamprey
Feature 1                                   #   #  #        # #                      #           
1FM6_D        91 ITEYAKSIPGFvnLDLNDQVTLLKYGVHEIIYTMLASLMNKdGVLISEGQGFMTREFLKSLRkpfgDFMEPKFEFAVKFN 170 human
2J14_A       104 LTEFAKSIPSFssLFLNDQVTLLKYGVHEAIFAMLASIVNKdGLLVANGSGFVTREFLRSLRkpfsDIIEPKFEFAVKFN 183 human
NP_001001460 294 ITEFAKNIPGFvnLDLNDQVTLLKYGVHEIIYTLLASLMNKdGVLISDGQGFMTREFLKSLRkpfcDFMEPKFEFAVKFN 373 chicken
Q7T029       351 VTEFAKSIPGFtdLDLNDQVTLLKYGVIEVLIIMMSPLMNKdGTLISYGQIFMTREFLKSLRkpfcQMMEPKFEFSVKFN 430 plaice
Q4H2X4       240 LTEFAKRLPNFhdISLQDQVILLKYGSYETMFVLFSRLIYGeGMILPKSNIYVTFNFVYQLGva-gDIMKSKFLFAKKML 318 Ciona intestinalis
P37233       215 LTDFAKRIPGFgtLYLNDQVTLLKYGVHEAIFCMLASLMNKdGLLVAGGRGFVTREFLRSLRqpfcHIMEPKFHFASKFN 294 African clawed ...
XP_781750    199 LAKFAKKLQEFknLDLNDQVCLLKHAAFEVALIATSSRYASeGLWFPTDGVYFTKKMLEQLEi---SFFDGKFKFFEKMK 275 purple urchin
XP_784429    295 FATFAKQLPEFrrLSSSDQLTLFKGAALEVCATLSASRYYHgVYRFPEINTYIRRDVAENSPfgkvTTYTTEMMFYEMFN 374 purple urchin
AAL26245     255 VTEFAKSIPGFmiLDLNDQVTLLKYGVYEVIFAMLAAQINKdGLLIAYGSAFITREFLRSLRspfcHIMEPKFEFSIRFN 334 sea lamprey
Feature 1                                                                                 #      
1FM6_D       171 aLELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPessQLFAKLLQKMTDLRQIVTEHVQLLQV 250 human
2J14_A       184 aLELDDSDLALFIAAIILCGDRPGLMNVPRVEAIQDTILRALEFHLQANHPdaqYLFPKLLQKMADLRQLVTEHAQMMQR 263 human
NP_001001460 374 aLELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPessQLFAKLLQKMTDLRQIVTEHVQLLQI 453 chicken
Q7T029       431 tLELDDSDMALFLVVIILSGDRPGLLNVKPIEQLQETVLHSLELQLKLNHPdslQLFAKLLQKMTDLRQIVTDHVHLIQL 510 plaice
Q4H2X4       319 aLELTDDEMALFVAMIILCPDRPEINDRKLVERIQEKVLFALEYQLSISHPhkpRLFAHLLLKMAELRELVSKHVVMVQK 398 Ciona intestinalis
P37233       295 aLELNDSDLALFVASIILCGDRPGLINPSQVEDIQEGILGALRRHLKASHTdapFLFPKLLHKMADLRQLVTEHAELVQS 374 African clawed ...
XP_781750    276 kLNLTERELALFCVLSLTSPDRDELIERDEVEKFQEQVLEAIQIELRTNHSnhrMLLPRLLSLLVDLRQLVLDHIKQVQQ 355 purple urchin
XP_784429    375 eLGLTDKEKAVFCTFLLYSPDREGLVDREVVERHQEHLAQILYLEVKKNHPdrsNLYAKLMDVAVALRTLVPDHLARLEQ 454 purple urchin
AAL26245     335 aLSLDGTDLALYMAAIILCGDRPGLINVNPVERIQDRILQALDLQLRKTHPespFLFPKLLQKLSDLRQLVTEHAQMVHN 414 sea lamprey
Feature 1                                
1FM6_D       251 IKKtet---dmsLHPLLQEIYKDL 271 human
2J14_A       264 IKKtet---etsLHPLLQEIYKDM 284 human
NP_001001460 454 IKKtet---dmsLHPLLQEIYKDL 474 chicken
Q7T029       511 LKKtev---dmcLHPLLQEIMKDL 531 plaice
Q4H2X4       399 LADak-----dfVPPLLCEIMQDM 417 Ciona intestinalis
P37233       375 IKRtes---saaLHPLLQEIYRDM 395 African clawed frog
XP_781750    356 LMLmddp-sysgPPPLIKEIFGLY 378 purple urchin
XP_784429    455 IKMrcnghlpaePSPLLNEVYGSI 478 purple urchin
AAL26245     415 IRKtea---dtaLPPLLQEIFKDM 435 sea lamprey

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap