2J14,2NXX,3BEJ,1XV9,1FM6,2HBH,3CQV,1XAP,1NAV,1S0X,1UPV


Conserved Protein Domain Family
NR_LBD_F1

?
cd06929: NR_LBD_F1 
Click on image for an interactive view with Cn3D
Ligand-binding domain of nuclear receptor family 1
Ligand-binding domain (LBD) of nuclear receptor (NR) family 1: This is one of the major subfamily of nuclear receptors, including thyroid receptor, retinoid acid receptor, ecdysone receptor, farnesoid X receptor, vitamin D receptor, and other related receptors. Nuclear receptors form a superfamily of ligand-activated transcription regulators, which regulate various physiological functions, from development, reproduction, to homeostasis and metabolism in animals (metazoans). The family contains not only receptors for known ligands but also orphan receptors for which ligands do not exist or have not been identified. NRs share a common structural organization with a central well conserved DNA binding domain (DBD), a variable N-terminal domain, a flexible hinge and a C-terminal ligand binding domain (LBD).
Statistics
?
PSSM-Id: 132727
View PSSM: cd06929
Aligned: 36 rows
Threshold Bit Score: 145.443
Threshold Setting Gi: 3882948
Created: 19-Nov-2008
Updated: 2-Oct-2020
Structure
?
Program:
Drawing:
Aligned Rows:
 
ligand bindingcoactivator
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:ligand binding site [chemical binding site]
Evidence:

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1             ##   #                                 #   #  #                            
2J14_A        87 VHVFYRCQCTTVETVRELTEFAKSIPSFssLFLNDQVTLLKYGVHEAIFAMLASIVNkdgllvangsgfvt----reflr 162 human
1FM6_D        74 IRIFQGCQFRSVEAVQEITEYAKSIPGFvnLDLNDQVTLLKYGVHEIIYTMLASLMNkdgvlisegqgfmt----reflk 149 human
AAC77795     296 LNAWQIYAHEIDVDIKEVVNFVKEIPKFnfINGNDKAVLLRKNAFPLYLLRIVRGMSnrglmlrdgrli--------dfk 367 nematode
XP_783869    378 SSLMDSMLGCMTDIIRRVVSFCKRIPGFpeLPIQDRTALIKNNMFEMVLVHSSHLVErnelfvvmgdphli----lpmel 453 purple urchin
XP_781794    189 QMWCSVVTQALAAYIKRIVTFCKHIPGFalLCQQDQMVLVKSGLFEILTIQDSIELIlydafvlnediri------sken 262 purple urchin
XP_001193835 563 GDKEDAFCDRFAPIISRIVSFAKATEGFedIPHEDQLTLLKAGCFEVLLLQLSQILDpesdfivftngek-----fhrgl 637 purple urchin
ABU89803     374 SKMWEQFVQNMVPEITMVVKFCKKIPGFneICQEDQINLIKQGSFEVMLVRMCNLVDtekeemfdpdmkmk----cpkav 449 Mediterranean m...
Q24143       523 NPKLLQLINLTAVAIKRLIKMAKKITAFrdMCQEDQVALLKGGCTEMMIMRSVMIYDddraawkvphtkenm--gnirtd 600 fruit fly
Q9XYB7       361 PKSIDGVFRIIEEALRRIVNMACQLSLFreLHVDDRKNLLKSGFGELLIVRGLMAYDksdnswnhsfgvrgk-mevkvev 439 Caenorhabditis ...
XP_001896592 305 ELSLMDVVRMTDLALRRIINMAKELTFFksLSSKDQISVLKGSCSELLILRGVMVFDqkkhawntsviqspaeleiklei 384 agent of lympha...
Feature 1                 #                                                                      
2J14_A       163 slrkpfsdIIEPKFEFAVKFn-aLELDDSDL--ALFIAAIILCGDrpgLMNVPRVEAIQDTILRALEFHLqanhp----- 234 human
1FM6_D       150 slrkpfgdFMEPKFEFAVKFn-aLELDDSDL--AIFIAVIILSGDrpgLLNVKPIEDIQDNLLQALELQLklnhp----- 221 human
AAC77795     368 slqllygsLADEMLAFANHIi-tIGCTDGDI--ALFIVLILCQPLt-tEQQFSTNFKSQLQLLEMFDFYKkvlfqkmtcr 443 nematode
XP_783869    454 lkmvpfsgTIVPLFRLNDRIq-sLGLSSRET--SLLCAMVMLAPDgedIEHRDTISVLQNRVAQALRREIrsslr----- 525 purple urchin
XP_781794    263 imkfmpveLYQGIYTFAERInmkLRLTRPEI--ALLSAVVLFADDregLQDVISVSRIQSRLLTALHIEVlrnhr----- 335 purple urchin
XP_001193835 638 lqksdvgdLVLALSKIASQLn-qLNLSLPER--ALLQASILVASDrkgIQSVDEVRSLQTHLLGVLEKFLyatha----- 709 purple urchin
ABU89803     450 vlgmpmgtFLVEFFKVAKAFn-pLQLTDGEI--GIFTATLIICPDrksIINSVAIMKLQLLLMQALYVLIkknhs----- 521 Mediterranean m...
Q24143       601 llkfaegnIYEEHQKFITTFdekWRMDENII--LIMCAIVLFTSArsrVIHKDVIRLEQNSYYYLLRRYLesvysg---- 674 fruit fly
Q9XYB7       440 lknpkleeHYKAHMNLLSTFg--EDVRNNEHlmLIFNAAVIFHPHvsnLRDSKRVHSTQAKYFQMLLKLLtfeygk---- 513 Caenorhabditis ...
XP_001896592 385 lknskelkHYEEHKRFLTTFg--EKWGKNEYimLLLNAITLFSPFrtnLQDIQKLQKIRQRYCDVLRRYLgnlyvt---- 458 agent of lympha...
Feature 1                               #    
2J14_A       235 -daqyLFPKLLQKMADLRQLVTEHAQMM 261 human
1FM6_D       222 -essqLFAKLLQKMTDLRQIVTEHVQLL 248 human
AAC77795     444 idgcdTYKQLMKCIHELNRLNELHKQQL 471 nematode
XP_783869    526 vdpddTFMQLFIVLPMLREMNVAHRNLV 553 purple urchin
XP_781794    336 -sdphMFAKCLLLLPMLRTVDDFHNQFI 362 purple urchin
XP_001193835 710 -pdalVFHKCLQVVLDLRVLNLKYSEKL 736 purple urchin
ABU89803     522 -dyasLFIELMKRIPIFRGINAKHAKML 548 Mediterranean mussel
Q24143       675 cearnAFIKLIQKISDVERLNKFIINVY 702 fruit fly
Q9XYB7       514 sradiAYSNLLNQVVELHRVNRTLLRVF 541 Caenorhabditis elegans
XP_001896592 459 seaerAYQELLKKLDDELNHLSHSLLRI 486 agent of lymphatic filariasis

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap