1WKX,1Q9B,2DKV


Conserved Protein Domain Family
ChtBD1_GH19_hevein

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cd06921: ChtBD1_GH19_hevein 
Click on image for an interactive view with Cn3D
Hevein or Type 1 chitin binding domain subfamily co-occuring with family 19 glycosyl hydrolases or with barwin domains.
This subfamily includes Hevein, a major IgE-binding allergen in natural rubber latex. ChtBD1 is a lectin domain found in proteins from plants and fungi that bind N-acetylglucosamine, plant endochitinases, wound-induced proteins, and the alpha subunit of Kluyveromyces lactis killer toxin. This domain is involved in the recognition and/or binding of chitin subunits; it typically occurs N-terminal to glycosyl hydrolase domains in chitinases, together with other carbohydrate-binding domains, or by itself in tandem-repeat arrangements.
Statistics
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PSSM-Id: 211312
Aligned: 9 rows
Threshold Bit Score: 47.484
Created: 26-Nov-2008
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
carbohydrate
Conserved site includes 7 residues -Click on image for an interactive view with Cn3D
Feature 1:carbohydrate binding site [chemical binding site]
Evidence:
  • Comment:Sequence variations in the binding site can affect binding specificity and binding affinity.
  • Comment:Glycines stabilize the site and may not directly contact the substrate
  • Structure:1Q9B: Hevea brasiliensis hevein binds two molecules of (4S)-2-methylpentane-2,4-diol in the carbohydrate binding site; contacts at 4 A
  • Citation:PMID 1936279

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                          # ### #   ##            
1WKX_A         1 EQCGRQAGGKLCPDNLCCSQWGWCGSTDEYCSPdhNCQSNCK 42  Para rubber tree
EFJ22468      20 EDCGRQAGGRTCPPGICCSKWGWCGVTTDHCGD--GCQSQCG 59  Selaginella moellendorffii
ABK24218      27 EQCGRQASGALCPGGLCCSKWGWCGNTEAHCGQ--DCQSQCG 66  Sitka spruce
AEF59005      27 EQCGQQAGGALCPGGLCCSKWGWCGNTDAHCGQ--DCQSQCG 66  lodgepole pine
1Q9B_A         1 EQCGRQAGGKLCPNNLCCSQWGWCGSTDEYCSPdhNCQSNCK 42  Hevea brasiliensis
Q41596        22 EQCGRQAGGALCPGGLCCSQFGWCGNTDDYCKKenGCQSQCS 63  cacao
2DKV_A         2 EQCGAQAGGARCPNCLCCSRWGWCGTTSDFCGD--GCQSQCS 41  rice
XP_001767856  30 EQCGRQAGGATCPGGLCCSQFGWCGSNAEYCGD--GCQSQCG 69  Physcomitrella patens subsp. patens
CAB97002      27 VQCGTEAGGALCPRGLCCSQWGWCGSTIDYCGP--GCQSQCG 66  Phaseolus vulgaris

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