2ITF,2E7D,2K78


Conserved Protein Domain Family
NEAT

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cd06920: NEAT 
Click on image for an interactive view with Cn3D
NEAr Transport domain, a component of cell surface proteins.
NEAr Transporter (NEAT) domain; used by pathogenic bacteria to to scavenge heme-iron from host hemoproteins. The NEAT domain is a component of cell surface proteins (iron regulated surface determinants, or Isd, such as IsdA and IsdC) in various gram-positive bacteria, and may be arranged in tandem repeats.
Statistics
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PSSM-Id: 132993
View PSSM: cd06920
Aligned: 104 rows
Threshold Bit Score: 48.0743
Threshold Setting Gi: 167768393
Created: 14-Nov-2008
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
heme-binding
Conserved site includes 10 residues -Click on image for an interactive view with Cn3D
Feature 1:heme-binding site [chemical binding site]
Evidence:
  • Comment:A conserved Tyrosine residue coordinates the iron in the bound heme
  • Structure:2ITF: IsdA NEAT domain from Staphylococcus aureus binds heme, contacts at 4 A
    View structure with Cn3D
  • Structure:2K87: IsdC NEAT domain from Staphylococcus aureus binds zinc protoporphyrin, contacts at 4 A
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                   #         ##  #                                  #                   
2ITF_B         7 ATSQPINFQVQKDGSSe--kSHXDDYXQHPGKVIKQnnKYYFQTVLNNa----------sFWKEYKFYnan--------- 65   Staphylococcus...
YP_877540    509 DGQYTIGFTAYKVDDPtd-tSMLGGFFDSNVKVEVK--KGKIYTTWLNlle-------adMLYDFRIEnng--------- 569  Clostridium no...
ZP_02440446  450 DGIYKVDAKMLKTNGKd--lSMANDAIAHKVKLTVKdgKYYVTLNLKAmnipfggqtfhgYLNKIQYIeng--------- 518  Clostridium sp...
NP_607878    978 DGIYYLNASMLKTDLAs--eSMSNKAINHRVTLVVKkgVPYLEVEFRGikvg----kmlgYLGELSYFvdgyqrdlagkp 1051 Streptococcus ...
ZP_02440447  248 DGIYSISGKMLKTDKKt--eSMANEAINHKIKLTVKngKYDITLDFKGlnis----ssygYLSKIKYFtntykidqykvp 321  Clostridium sp...
NP_607878    371 EGTYTLNFKANKENSEe--sSMLQGAFDKRAKLVVKa-DGTMEISMLNtal-------gqFLIDFSIEskgt-------- 432  Streptococcus ...
ZP_02866397  141 DGKYQFAFTIYKLNKLe--iSMANDGFVHPGILEINngKGNLILFPKEieh-------esLLGNIILK------------ 199  Clostridium sp...
YP_877539    239 DGVYTLTFRAYKIENPae-dSMLNNFFDKKAKLEVK--DGKKTITFLNicf-------adGLYDFRIEtn---------- 298  Clostridium no...
ZP_02440441  152 KGIYQVAFSIYRQGKDwqslSMADQGFEKPAYLHLKgdKNYLELAVREmkamt---kggaMLSGHIQTvk---------- 218  Clostridium sp...
ZP_02440445  240 DGVYTVTLKATKQGSKe--pSSLGGYFEGKAKLTVK--DGEMKLSMLNism-------akYLLDFTLEtd---------- 298  Clostridium sp...
Feature 1                                                                      # #               
2ITF_B        66 ----nqELATTVVNDNKK---------ADTRTINVAVEp-------------gYKSLTTKVHIVVPqi-----------n 108  Staphylococcus...
YP_877540    570 ---kypKAKSTKYGEPDNyg------kYNMQTFEIPMDn-------------fIKPHIGGVIVSAMggqks-----dign 622  Clostridium no...
ZP_02440446  519 ---tekDVTVDQIQKNTN---------GDIVSDEFGSNypdlvtfpltdeaveTGIAPMQVFIPIMdsia-------sgm 579  Clostridium sp...
NP_607878   1052 vgrtkkAEVVSYFTDVTGlpladrygkNYPKVLRMKLIeqa----------kkDGLVPLQVFVPIMdai---------sk 1112 Streptococcus ...
ZP_02440447  322 igslknVTIDSYQKDTKGkkvrdsygsNYPDQVTFPLIsra----------knDGYVPLQVFVPIMdai---------sp 382  Clostridium sp...
NP_607878    433 ---ypaAVRKQVGQKDINg-------sYIRSEFTMPIDd-------------lDKLHKGAVLVSAMggqes-----dlnh 484  Streptococcus ...
ZP_02866397  200 ------GQVESLKYMLDQefis-sqniKNSYIIPIDRLkfhy--------ckeERILQTSIKIKVRan----------vg 254  Clostridium sp...
YP_877539    299 -----kIFKESQISDYGNknp----dtEKYPAKLFKMEid-----------dlDSDHKGCVLAGPMggklsdygkvtydk 358  Clostridium no...
ZP_02440441  219 ----crSSKDVLTDLPIQ---------DKKIQIPFEDFefe---------qlsETEITGQIQLFMTss-----------v 265  Clostridium sp...
ZP_02440445  299 ----gtFAQATKEAYGDAn--------SDGSYDAYEYTm--------------SIKDLSKIHTAAAlvsvmgs-esdkgn 351  Clostridium sp...
Feature 1        #   # #         
2ITF_B       109 YNHRYTTHLEFEKAIP 124  Staphylococcus aureus
YP_877540    623 INKYTKVKLVFDKEII 638  Clostridium novyi NT
ZP_02440446  580 GTQKMNLSLDFTSAVK 595  Clostridium sp. SS2/1
NP_607878   1113 GSGLQTVFMRLDWASL 1128 Streptococcus pyogenes MGAS8232
ZP_02440447  383 GSGTQAVYLKLDLNSI 398  Clostridium sp. SS2/1
NP_607878    485 YDKYTKLDMTFSKTVT 500  Streptococcus pyogenes MGAS8232
ZP_02866397  255 IIHMPESCAVLNIILK 270  Clostridium spiroforme DSM 1552
YP_877539    359 ANNYKTVMFKFNKDFA 374  Clostridium novyi NT
ZP_02440441  266 GEKRMPESMATLIVKL 281  Clostridium sp. SS2/1
ZP_02440445  352 YDKYMKADITFTSLEK 367  Clostridium sp. SS2/1

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