Conserved Protein Domain Family
GT8_GNT1

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cd06914: GT8_GNT1 
GNT1 is a fungal enzyme that belongs to the GT 8 family.
N-acetylglucosaminyltransferase is a fungal enzyme that catalyzes the addition of N-acetyl-D-glucosamine to mannotetraose side chains by an alpha 1-2 linkage during the synthesis of mannan. The N-acetyl-D-glucosamine moiety in mannan plays a role in the attachment of mannan to asparagine residues in proteins. The mannotetraose and its N-acetyl-D-glucosamine derivative side chains of mannan are the principle immunochemical determinants on the cell surface. N-acetylglucosaminyltransferase is a member of glycosyltransferase family 8, which are, based on the relative anomeric stereochemistry of the substrate and product in the reaction catalyzed, retaining glycosyltransferases.
Statistics
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PSSM-Id: 133064
View PSSM: cd06914
Aligned: 8 rows
Threshold Bit Score: 325.918
Threshold Setting Gi: 74606800
Created: 24-Sep-2008
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative ligandmetal binding
Feature 1:putative ligand binding site
Evidence:
  • Comment:annotation is based on homology to other subgroups of the superfamily

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1             ###  ##                                                                    
Q6BUZ2        68 YAYVQYATDfDYLNLAIINFIVLRRSStkIPNLVVLFNraLQEDKNRFDGlrdls------------lrysvTLKPIPII 135  Debaryomyces h...
Q59ZI3        71 YAYMQYATNyDYLNLAIINFIHLRKANtkIPNLVIIYDevLHYYASDKWSelyqva-----------nqykiTLKAAPLI 139  Candida albicans
Q4WBL2        80 YAYSQYATSsAYLCNAVMVFEALERLGs-RADRVLFYPedWDLFVADDHDrdsqll-----------vlakeKYKALLVP 147  Aspergillus fu...
XP_001597311 107 YAYITYATSkDHLCNALMLFESLQRLQs-KAERVLLYPqlWKDAWVEDVHgtdmeiisk----mliqardkyKVKLENVE 181  Sclerotinia sc...
Q9Y761        96 YAYVNYVADkNYVCSSMIHFNRLHESGt-QAKLVMLVAkeLTELPEDDSVtrmlaqf--------keisdncIVKPVENI 166  Kluyveromyces ...
Q6CT96        85 FAYVNYITDfEYLCNTLIQFRKLNDSGs-KAKLLALVTdtLVNKSKENKEveallnkiksvsdrvavtevgsVIQPNDHT 163  Kluyveromyces ...
Q12096        92 FAYVNYVTNaDYLCNTLIIFNDLKQEFetKAKLVLLISkdLLDPNTSSNVayissllnk----iqaidedqvVIKLIDNI 167  baker's yeast
EAU91595     698 FAFVFYATNaGYACGALLLIKQLSSLSp-GISTVLMVPptFLPRNLVPFQrfn-----------------ttIVKLKPPP 759  Coprinopsis ci...
Feature 1                             #                 # ###                                    
Q6BUZ2       136 envna------esptWSKSFTKFHIFNE----VKYDRIVYFDADSMLLHtqwndnssivnnesnvpeNLDELFtip--ei 203  Debaryomyces h...
Q59ZI3       140 kasyq------ddsnWAASFTKFHIFNQ----VEYDRIVFFDSDSMLVDipneidfd---nmesrfnHIDELFkip--qe 204  Candida albicans
Q4WBL2       148 isaemikagggsgesWDKSIAKLLAFGE----TEYDRVIHIDSDVTVLQ------------------SMDELFflp---p 202  Aspergillus fu...
XP_001597311 182 ilqhrh----atadeWAESYTKLIAFNQ----TSYEKLLVLDSDSTIRH------------------PMDELFvapmsns 235  Sclerotinia sc...
Q9Y761       167 vlsq-------gsaqWMTSMTKLRVFGM----VEYKRIVYFDSDSIITR------------------NMDELFflp--dy 215  Kluyveromyces ...
Q6CT96       164 p--------------WSKSLTKLAIFNL----TDYERIIYMDNDAIIHD------------------KMDELFflp--sy 205  Kluyveromyces ...
Q12096       168 vkpk-------dttpWNESLTKLLVFNQ----TEFDRVIYLDNDAILRS------------------SLDELFflp--ny 216  baker's yeast
EAU91595     760 lagg-------gdayYWSALLKLRAFQLqeqlPDLKRIIVMDSDQIIRK------------------PLHHLFhlp---e 811  Coprinopsis ci...
Feature 1               #                                                                        
Q6BUZ2       204 iDIALPQAYWltkhtkasgkikapdgkgyqdeitaline---------------------------isksvndslvfekl 256  Debaryomyces h...
Q59ZI3       205 lSFASPQAYWlnnvvegksprprknveipnkkryslrmkk--------------------------lvndlsiyqdfnll 258  Candida albicans
Q4WBL2       203 aKVAMPRAYWalp------------------------------------------------------------------- 215  Aspergillus fu...
XP_001597311 236 tQILAPRAYWldaq------------------------------------------------------------------ 249  Sclerotinia sc...
Q9Y761       216 iQFAAPATYWflndndlpqliednkqialannqtaelteiedilqq-------------kiddsediynflpnlpkrlyp 282  Kluyveromyces ...
Q6CT96       206 vKFAAPISYWfvtaddlrtvstdtkklfktnkldpiekklasrvkn-------------sleiynhlpnlpqhfysksmn 272  Kluyveromyces ...
Q12096       217 iKFAAPLTYWflsnsdleksyhetrhrekqpinlqsytkvltkrigkgqmiynhlpslphslylnsnniaqdiisstssl 296  baker's yeast
EAU91595     812 vEVAAPVAYWlen------------------------------------------------------------------- 824  Coprinopsis ci...
Feature 1                         ###                                      ##                    
Q6BUZ2       257 psllvqsqklnhrnnFFATHVMVVKPSnEIFNELKKYVHNPwlwslhkrhalrnksDYDMEVLNKFIDnvlqen------ 330  Debaryomyces h...
Q59ZI3       259 psliyenhyfdnanhFFANHIMVITPSkNTFQELMRYIHNPwwwsitnrgslrkpnDYDMEILNKYLNnelqr------- 331  Candida albicans
Q4WBL2       216 ------------dtkTLSSLLIVIEPSyREFKALMESAQPAlhgqvev--dsnetqRYDMELLNNRYAds---------- 271  Aspergillus fu...
XP_001597311 250 ------------gipQLASHIMLIKPStSAFERLQVEFKKAgl------------gTYDMDIINSAFTeqk--------- 296  Sclerotinia sc...
Q9Y761       283 ksdnaridstdntyfKYAATLMVIKPEqEMFERLEQEVLPKyln---------ttnKYDMDLINIEFYdfngtaeaqkkl 353  Kluyveromyces ...
Q6CT96       273 fiididgfqksdnkvNFATHLMVIKPDvTMANDIRDNILPRylk---------akeEYDTDLINEELYnfkeliyyqfki 343  Kluyveromyces ...
Q12096       297 splfdfqsskkvgklKFASNLMVINPSkEAFDEIVNVMLPKiln---------kkeKYDMDLINEEMYnlkkiiykqfif 367  baker's yeast
EAU91595     825 -------------teYTTSALMVISLSkRLSKEVTTALTTIrs------------kEYDMDLVNRLFYps---------- 869  Coprinopsis ci...
Feature 1                              ##                                           # ##    #    
Q6BUZ2       331 -------enfkvGILPHKVYGVLTGefrellhesfvseaqflp--fitgelneqwrpieiirnIKLIHFSDspiPKPWEG 401  Debaryomyces h...
Q59ZI3       332 -------krinvGILPHRVYGVLTGefgeewherfvvepqylp--finkksnkgwspleffkkIKVVHFSDspiPKPWEE 402  Candida albicans
Q4WBL2       272 -----------aLVLPHRQYGLVTGefrkkdhrsffgn------------dyetwdpdkvlaeAKLVHFSDwplPKPWVL 328  Aspergillus fu...
XP_001597311 297 ---------dscGLLDHQIYALLTGefrrpitkhsgfwgk--------ghemdiwdpesvfkkSKFVHFSDwpmRKPWKL 359  Sclerotinia sc...
Q9Y761       354 ydqspqsfkpsmLVLPFNQYTLLTKtireknrvkllsnd----------mlgyetkkptdfrdASYYHFSDspiGKPWKY 423  Kluyveromyces ...
Q6CT96       344 frkiqylfkpsvLILPYTKYGLLTKsiddkrqkdllknai---------lgyerkekddliqdAKFIHFSDyplSKPWFY 414  Kluyveromyces ...
Q12096       368 frkvrklfkpevLVLPFARYGLLTGslrnprhysiiyndvlgyktldndgndipvglndsvaySKYIHFSDyplAKPWNY 447  baker's yeast
EAU91595     870 ----------rmLVLPGSYCTLNSHwesselpdwmqn--------------ktkglqglweeeSQVIHFSAg--GKPWNV 923  Coprinopsis ci...
Feature 1                                                             
Q6BUZ2       402 mnnfhfynkfriychdagfdadlfnslfptswkprlttdcdsVNIWNWIMAEY 454  Debaryomyces hansenii
Q59ZI3       403 enneehynikkiycdkgdme---kfhkdypvykprltddcdsVSIWNWFREQF 452  Candida albicans
Q4WBL2       329 snqkllaeilpkcd---------------fkpgtmqergcrdREVWKSLYEDF 366  Aspergillus fumigatus
XP_001597311 360 nnlewtvwapkc-------------------vpveegddcraRDIWDGLYKDF 393  Sclerotinia sclerotiorum 1980
Q9Y761       424 kgledipc--------------------------npgdseeiCNAWHSIFSNF 450  Kluyveromyces lactis
Q6CT96       415 snaddiqcs------------------------kkysisdenCQLWKSLYKEY 443  Kluyveromyces lactis
Q12096       448 psmkefecivke------------------edaedsklehqaCDLWNSVYASY 482  baker's yeast
EAU91595     924 nmrrmnrlreqgkvdg----------mfvkmvedwreeadktCVLGWQGRAPL 966  Coprinopsis cinerea okayama7#130

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