Conserved Protein Domain Family
beta3GnTL1_like

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cd06913: beta3GnTL1_like 
Beta 1, 3-N-acetylglucosaminyltransferase is essential for the formation of poly-N-acetyllactosamine .
This family includes human Beta3GnTL1 and related eukaryotic proteins. Human Beta3GnTL1 is a putative beta-1,3-N-acetylglucosaminyltransferase. Beta3GnTL1 is expressed at various levels in most of tissues examined. Beta 1, 3-N-acetylglucosaminyltransferase has been found to be essential for the formation of poly-N-acetyllactosamine. Poly-N-acetyllactosamine is a unique carbohydrate composed of N-acetyllactosamine repeats. It is often an important part of cell-type-specific oligosaccharide structures and some functional oligosaccharides. It has been shown that the structure and biosynthesis of poly-N-acetyllactosamine display a dramatic change during development and oncogenesis. Several members of beta-1, 3-N-acetylglucosaminyltransferase have been identified.
Statistics
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PSSM-Id: 133063
View PSSM: cd06913
Aligned: 8 rows
Threshold Bit Score: 400.68
Threshold Setting Gi: 198438469
Created: 17-Nov-2008
Updated: 2-Oct-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q6GV29        18 IILPVHNAEQWLDECLMSVLQQdfe--gtmELSVFNDASKDksraiiekwkvkleds-gisvvigghdspsprGVGYSKN 94  Norway rat
CAG06068       2 IIMPVYNASCWLDECLRAISQQdft--gslQLSVFDDASTDydgngtqr----------------qsnalscfSVGYAKN 63  Tetraodon nigro...
XP_415599     18 VIVPVHNSECWLDECLKSVWEQdfk--qtmELSIFNDASKDgsaeiiakwkvkleda-gvpvvvgsndsaqprGVGFAKN 94  chicken
XP_001197781   8 IIMPVHNGEPWLVECLESVLAQkfs--gsiQLSVYNDASNDksatilegfrskmek--agicmlinghngtpvGVGAARN 83  purple urchin
Q67FW5        22 IILPVHNAEPWLDECLRSVLQQdfe--gtmELSVFNDASKDksgaiiekwrvkleds-gvhviigghdspsprGVGYAKN 98  human
AAI58333      12 IILPAYNAEAWLDECLESVAQQdfd--gclEVSIYNDASKDgtaqkiedwrarlegq-gitvivgshnspqpkGVGYAKN 88  western clawed ...
EEB11236       9 IIIPIHNGEQWINECFESILTQdilktngiEISVFNDASTDrtselllywekkisninnlsllvqhgnydypkGVGFAKN 88  human body louse
XP_002130237  12 IITPIYNGEQFVNSCIQSVLDQthr--gplELCIFNDGSTDssmekvnsfskklks--rnislsisslfntpkGCGFAKN 87  Ciona intestinalis
Q6GV29        95 QAIAQSTGSYLCFLDSDDVMMPQRVRMQYEAAvqh-paSIIGCQVRRDPPDSTERYTRWINQLtsdQLLTQVFTSHGPTV 173 Norway rat
CAG06068      64 KAVSQSCGRYLCFQDADDVMLPERVRLQYEASllh-paSLIGCKIQRIPEGSTERYTRWINTItrdQLVTQVYTSHGPTV 142 Tetraodon nigro...
XP_415599     95 QAIIQSSGTYLCFLDSDDVMMPQRVRLQHEAAiqh-pnSIIGCQVRREPPESTARYTRWINNLteeQLLTQVFTSHGPTV 173 chicken
XP_001197781  84 RAIEASSGQCLCFLDADDVMDSRRIEMQYAAAvtr-pnAIVGCQFRRRPEDSTPRFTDWCNRLkreQLYTQAYTSHGPTV 162 purple urchin
Q67FW5        99 QAVAQSSGSYLCFLDSDDVMMPQRVRLQHEAAvqh-psSIIGCRVRRDPPNSTERYTRWINQLtpeQLLTQVFTSNGPTV 177 human
AAI58333      89 RAILQSSGRYLCFLDSDDVMMPQRIRMQYEAAlqr-pqSIIGCQVQRVPEGATERYTRWINSLtqeQLLTQVFTSHGPTV 167 western clawed ...
EEB11236      89 QAIAQCNGKYLCFQDIDDVMHPQRISLQLLEAkky-snAIVGCQIKRIPENSTPRFSTWVNHLpqnLLSTQIYTSHGPTV 167 human body louse
XP_002130237  88 RCVEQSKGEYLCFLDIDDVMHPDRIKDQLTAAlslpplTLIGCQVIREPEDATVRYTRWINTIsssQLYTQIYTSHGPTV 167 Ciona intestinalis
Q6GV29       174 IMPTWFCSRAWFSHVGPFDEGGQGVPEDLLFFYeHLRKGGGVFRVDHSLLLYRYHLCAATHSV 236 Norway rat
CAG06068     143 IMPTWFCSRSWFLDVGPFDEGGKGVPEDLLFFYrSIRRGGGVFRVDQCLLVYRYHEKATTHSV 205 Tetraodon nigroviridis
XP_415599    174 IMPTWFCSREWFYHVGKFDEGGKGVPEDLLFFYkHLQKGGGVLRVNHCLLLYRYHPQAATHSV 236 chicken
XP_001197781 163 AMPTWFCSREVYENVGKFDESGKGTPEDLIFFKaHLEGGGKLYRVDEVLMMYRYHPGATTHSI 225 purple urchin
Q67FW5       178 IMPTWFCSRAWFSHVGPFNEGGQGVPEDLLFFYeHLRKGGGVIRVDQSLLLYRHHPQAATHCV 240 human
AAI58333     168 IMPTWFCSREWFCHVGQFVEDGKGSPEDLLFFYeHLRKGGGVYRVDRCLLLYRYHELAATHSV 230 western clawed frog
EEB11236     168 LMPTWFFSKNLFKKVGLFSEKGKGTPEDLLFFYaHLDLGGTVRRVDKVLLYYRYHSNCTTFSV 230 human body louse
XP_002130237 168 VMPTWFCHKSVFNLVGGFSEEGKGVPEDYIFFLrFLELKGKLHRVDRPLLTYRHHSGATTFSI 230 Ciona intestinalis
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