2E6V,2DUO


Conserved Protein Domain Family
lectin_VIP36_VIPL

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cd06901: lectin_VIP36_VIPL 
Click on image for an interactive view with Cn3D
VIP36 and VIPL type 1 transmembrane proteins, lectin domain
The vesicular integral protein of 36 kDa (VIP36) is a type 1 transmembrane protein of the mammalian early secretory pathway that acts as a cargo receptor transporting high mannose type glycoproteins between the Golgi and the endoplasmic reticulum (ER). Lectins of the early secretory pathway are involved in the selective transport of newly synthesized glycoproteins from the ER to the ER-Golgi intermediate compartment (ERGIC). The most prominent cycling lectin is the mannose-binding type1 membrane protein ERGIC-53, which functions as a cargo receptor to facilitate export of glycoproteins from the ER. L-type lectins have a dome-shaped beta-barrel carbohydrate recognition domain with a curved seven-stranded beta-sheet referred to as the "front face" and a flat six-stranded beta-sheet referred to as the "back face". This domain homodimerizes so that adjacent back sheets form a contiguous 12-stranded sheet and homotetramers occur by a back-to-back association of these homodimers. Though L-type lectins exhibit both sequence and structural similarity to one another, their carbohydrate binding specificities differ widely.
Statistics
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PSSM-Id: 173889
View PSSM: cd06901
Aligned: 12 rows
Threshold Bit Score: 457.241
Threshold Setting Gi: 221104003
Created: 24-Mar-2005
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
metal bindingcarbohydrate
Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1:metal binding site [ion binding site]
Evidence:
  • Structure:2E6V_A; The exoplasmic/luminal domain of Canis lupus familiaris VIP36 lectin binds Ca2+.
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                             
2E6V_A              5 HLKREHSLIKPYQGVGsssmpLWDFQGSTILTSQYVRLTPDERSKEGSIWNHQPCFLKDWEMHVHFKVHGTGkknLHGDG 84  dog
2DUO_A              5 HLKREHSLIKPYQGVGsssmpLWDFQGSTILTSQYVRLTPDERSKEGSIWNHQPCFLKDWEMHVHFKVHGTGkknLHGDG 84  dog
FlyBase:CG5510-PA  34 YMKREHSLVRPFQGVGvi-lpHWDFLGNTMVTSNYIRLTPDLQSKSGALWNYSPVMTRNWEVHVGFKVHGKGt-eLFGDG 111 fruit fly
AAH99020           45 YLKREHSLSKPYQGVGsstssLWDLLGNSLVTPQYVRLTPDLQSKQGAVWNRVPCYLRDWEMQVHFKIHGQGkknLNGDG 124 African cl...
ACH44464           34 HLKREHSLMKPYQGAGsaampLWDFTGSTMVTSQYVRLTPDERSREGSIWNRVPCFLKDWELHVHFRIHGAGkknLHGDG 113 zebra finch
XP_002114747       32 FLKREHTLVRPFQGTVlvyaeLWDFTGSTIVTGTHIRLTPDHQSKAGAIWNRIPCMLRNWEVLIHFKVHGNGv-dLYGDG 110 Trichoplax...
XP_002126496       38 FLKREYSLTKPYSSNGmt-mpFWDFRDRTMLTNNFIRLTSNHQAEVGSVWNKIPLYLRDWEMQVQFKVHGGGr-tLGADG 115 Ciona inte...
CAN88460           50 HLKREHSLIKPYQGVGsspssQWDFWGSTLVTSQYVRLTPDERSKQGSIWNTVPCYLKDWEMHVQFKIHGSGkknLHGDG 129 zebrafish
XP_783719          30 FLKREHSLMRPYTGAGas-lpMWDITGNTMVTNDYIRLTPDHQSMRGAVWNQVSNKSPHWELHLHFSVHGSGk-tLFGDG 107 purple urchin
EEC17711           36 YMKKEHSLVKPYQGAGmt-ipNWDFLGNTMVTGQYIRLTPDRQSSKGAIWNNVPCKSKNWEMHVHFKVHGSGk-eLFGDG 113 black-legg...
XP_001640775       25 YLRREHSLMRPYQGSGmt-ipNWDFHGSTFVSSNYIRLTPDHQSKQGSLWNNVPNYLKEWEMVLHFAVHGQGt-tLFGDG 102 starlet se...
XP_002162021       36 YMRREYSLIKPFHALQ-----YWEILGSTMVSVDYLRLTPDERSKAGSVWNILPCYIRNWEIHINFKIHGHGt-rLYGDG 109 green hydra
Feature 1                                          #   #                        #  #                  
2E6V_A             85 IALWYTRDRLVPGPVFGSKDNFHGLAIFLDTYPNdet-teRVFPYISVMVNNGSLSYDHSKDGRWTELAGCTADFRNRDH 163 dog
2DUO_A             85 IALWYTRDRLVPGPVFGSKDNFHGLAIFLDTYPNdet-teRVFPYISVMVNNGSLSYDHSKDGRWTELAGCTADFRNRDH 163 dog
FlyBase:CG5510-PA 112 FAIWYTKERMQTGPVFGSKDHFSGLAIILDTYSNhngphnHQHPYLSAMVNNGSWSYDHDRDGTHTQLAGCEVRFRNVEY 191 fruit fly
AAH99020          125 FALWYTKDRMQAGPVFGSKDNFVGLGLFVDTYPNeekqheRVFPYISAMVSNGSITYDHSRDGRPTELGGCTAMVRNLNH 204 African cl...
ACH44464          114 LALWYTQERLTPGPVFGSKDNFHGLAIFLDTYPNdea-teRVFPYISAMVNNGSLTYEHSKDGRGTELAGCSADLRNQNH 192 zebra finch
XP_002114747      111 FAFWLTKGRNEMGKVFGSKDPFSGLAIFFDTYSNqngehaHVHPYVSAVVNNGSMSYDHDYDGTHIQIAGCSAPFRGREH 190 Trichoplax...
XP_002126496      116 FAIWYTKERMTPGPVFGSRDEFHGLGVFFDTYKNgp--qaVTFPQITAMVGNGSVKYDHMTDGKSNAIGSCLASFRNKDY 193 Ciona inte...
CAN88460          130 FAMWYTKERLHPGPVFGNQDHFVGLAIFVDTFRNdlqgmdRSFPYISAMVNNGSLPYEHGKDGRSTELGGCSVEVRNKEH 209 zebrafish
XP_783719         108 FAIWYTKERMKDGPVFGNIDYFTGLGLFFDTYSNhngphnHAHPYISAQINNGTQHYDHDRDGTHTELAGCHAPFRNKDH 187 purple urchin
EEC17711          114 FAIWYAKEALQLGPVFGSKDKFSGLAIFFDTYANqngphnHGHPYISAMVNNGTLSYDHDRDGTHTELAGCEAKFRNLDH 193 black-legg...
XP_001640775      103 FAFWYTRDRSLEGPAFGSSANFYGLGVFFDTYSNhngehsHEHPYISAMVGNGTLPYDHDRDGTHSQVEGCSAQFRGLTH 182 starlet se...
XP_002162021      110 FAFWYSKERALQGPVFGNKDYFTGLALFFDTYANqngehqHEHPYISAQVSNGSVHYDHDRDGTHTQLAGCSVNFRGVAG 189 green hydra
Feature 1                                                                                             
2E6V_A            164 DTFLAVRYs--rGRLTVMTDLEDKNEWKNCIDITGVRLPTGYYFGASAGTGDLSDNHDIISMKLFQLMvehtp-----de 236 dog
2DUO_A            164 DTFLAVRYs--rGRLTVMTDLEDKNEWKNCIDITGVRLPTGYYFGASAGTGDLSDNHDIISMKLFQLMvehtp-----de 236 dog
FlyBase:CG5510-PA 192 ETLVSIRYe--nDILSVSTDLENRNEWKNCFVVANVELPTGYHFGMSATTGDLSDNHDIHSFKFYDLDlnvnh------d 263 fruit fly
AAH99020          205 DTFLVIRYv--kRRLTIMVDIDGKQEWKDCLDVPGVRLPRGYFFGASAVTGDLTDNHDLISLKLYQLSvertp-----ee 277 African cl...
ACH44464          193 DTFLAVRYs--rGRLTVMTDVEDKNEWKNCIDIAGVQLPTGYFFGASAGTGDLSDNHDIISMKLFQLMvehpl-----ed 265 zebra finch
XP_002114747      191 DTFASIRFv--nNRLTAKLDIDGNGEWRQCFDADEVFLPLGYFFGISAATGDLADNHDILTFKVFELPadets-----di 263 Trichoplax...
XP_002126496      194 DTLVSIKYv--kETLQIRLDIDGLGEWRECFSMPGVKLPTGYFIGMSAATGDLADNHDLINVKFFHMDagrsa-----ee 266 Ciona inte...
CAN88460          210 DTYLAIRYs--kGRLTIMVDVDDQNDWKECVDIGGVRLPTGYYFGASAATGDLSDNHDIISMKMYQLMvehtl-----ee 282 zebrafish
XP_783719         188 NTHVAIRYf--mKRLTVMMDITGEGKWQHCIDQTNIILPTGYYFGASAATGQLADNHDIHSVKVYELEgidl-------d 258 purple urchin
EEC17711          194 DTHIAVRYe--nDVLTVSTDIEGKNAWKECFTVKGVQLPTNYYFGASAVTGDLSDNHDIISMKLFEIDlptek-----qr 266 black-legg...
XP_001640775      183 DTFALIRYstsqERLTLLVDVDGKNEWRECFDVGGVKLPTGLYWGVSAATGQLADNHDIISMKLYEVDipevvrttetng 262 starlet se...
XP_002162021      190 ETHVAIRYlgskKRLTVQYDIDNDDSWKECLDKYGVEMPTGYYFGLSAQTGDLSDNHDILSLKFYELEnde--------- 260 green hydra
Feature 1                              
2E6V_A            237 eniDWTKIEPSVNFLKS 253 dog
2DUO_A            237 eniDWTKIEPSVNFLKS 253 dog
FlyBase:CG5510-PA 264 eiiRRSNIIPNAKTFEP 280 fruit fly
AAH99020          278 ekmDKEVFIPSVDYMKL 294 African clawed frog
ACH44464          266 etvDWTKIEPRVSLLKS 282 zebra finch
XP_002114747      264 sdtALLNLVPHAKTAEA 280 Trichoplax adhaerens
XP_002126496      267 eaeDWSTVLPGVSYLKP 283 Ciona intestinalis
CAN88460          283 dsqDWTKIEPSVSLLKS 299 zebrafish
XP_783719         259 ketDYSKLLPSAQYFAP 275 purple urchin
EEC17711          267 dteDRSKIVPSASYFAP 283 black-legged tick
XP_001640775      263 kqiDYTQIVPHADGAES 279 starlet sea anemone
XP_002162021      261 eegDYSNIIPNSNESEP 277 green hydra

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