Conserved Protein Domain Family
PX_MONaKA

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cd06871: PX_MONaKA 
The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
The PX domain is a phosphoinositide (PI) binding module present in many proteins with diverse functions such as cell signaling, vesicular trafficking, protein sorting, and lipid modification, among others. MONaKA (Modulator of Na,K-ATPase) binds the plasma membrane ion transporter, Na,K-ATPase, and modulates its enzymatic and ion pump activities. It modulates brain Na,K-ATPase and may be involved in regulating electrical excitability and synaptic transmission. MONaKA contains an N-terminal PX domain and a C-terminal catalytic kinase domain. The PX domain interacts with PIs and plays a role in targeting proteins to PI-enriched membranes.
Statistics
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PSSM-Id: 132781
View PSSM: cd06871
Aligned: 12 rows
Threshold Bit Score: 204.131
Threshold Setting Gi: 47210342
Created: 10-Jul-2008
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
phosphoinosit..
Feature 1:phosphoinositide binding site [chemical binding site]
Evidence:
  • Comment:A majority of PX domain containing proteins binds phosphatidylinositol-3-phosphate (PI3P) at this site. In some cases, other phosphoinositides, such as PI4P or PI(3,4)P2, are the preferred substrates.
  • Comment:based on the structures of phosphatidylinositol-3-phosphate bound to other members of this superfamily
  • Comment:Two basic residues are key in binding with phosphoinositides: one forms hydrogen bonds with the 3-phosphate of PI(3)P and another forms hydrogen bonds with the 4-and 5-hydroxyl groups of PI(3)P.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                   ###                    ##            #
Q8BX57         13 LLDDTVPLTAAVEASQsLQSHTEYIIRVQRGIsAENSWQIVRRYSDFDLLNNSLQITGLSLPLPPKKLIGNMDREFIAER 92   house mouse
NP_001090231   13 LLDDTVPLSAVIEASQsLHSHTEYIVRVQRGVsMENSWQIIRRYSDFDMLNNSLQISGLSLPLPPKKLIGNMDRQFIAER 92   African clawe...
XP_414403       1 MLDETVPLPAQIEASQsLHCHTEYIIRVQRGVsAENSWQIVRRYSDFDLLNNSLQISSLSLPLPPKKLIGNMEREFIAER 80   chicken
XP_972128     786 VLDDTEPLSCVIENWRnVNGHTEFVIKVQRGPfSDKTWRVYKRYNDFYKLHAYLQTSGISLQLPPKKLIGNMDPEFITER 865  red flour beetle
NP_001076277   17 PLDDTVPLSAVIEASQsLQSHTEYIIRVQRGVsTDNSWTVIRRYSDFDMLNNSLLISGLNLPLPPKKLLGNMDREFIAER 96   zebrafish
EDV29715        9 ECDDTIPLTCSIEKANiIDSHVEYVLIVQRGSnPENFWKVQRRYNDFVTLHAALQISGRDLPLPPKKLFGNLDKDFVAKR 88   Trichoplax ad...
XP_001640318   10 ALDDTVPLMCIFEGIS-KKEHVDYIIKVQRGAsPEGSWQVVHRYSDFAALHAALEVSGIEMPLPPKKVFGNMDTTFVVER 88   starlet sea a...
XP_392133      13 LLDDTEKLTSVIENARtIDGHTEYVIRTQRGPlSEKFWRVSRRYNDFVQLNAALSISGIDLAFPPKKIIGNMEPDFIAQR 92   honey bee
NP_610341      13 PIDDTQALSCEITAVQeVAGHTEYLLRVWRGAsNKNYWTVLRRYNDFDRLDKSLRVSGIELPLPRKRIFGNMRPEFIAER 92   fruit fly
XP_001847003   13 VLDDTEAIACHIETAQnIDGHTEYVLRVQRGPyPENSWRILRRYNDFASLNKCLQISGIELSFPGKKFIGNMRPEFIAER 92   southern hous...
XP_002124930   11 VIDDTELLTCNITGTEtIQSHTEFIIRVQRGPlKENSWQLRRRYNDFVVLHETLKIAGVDLPLPPKKLLGNMEREFIAAR 90   Ciona intesti...
CAF96010       13 LLDDTVPLTAVIEASQnAQSHTEYIIRVQRGVsAENSWQVIRRYSDFDLLNNSLMVCGISLLLPPKKLIGNMDRDFIAED 92   spotted green...
Feature 1                                                                        
Q8BX57         93 QRGLQNYLNVIMANh-----------------------VLSNCELLKKFLDPNNYSANYTEIA 132  house mouse
NP_001090231   93 QKGLQNYLNVITSNh-----------------------ILCNYEQVKKFFDPTNYSANYTEIA 132  African clawed frog
XP_414403      81 QKGLQAYLDVITSHh-----------------------LLSNCELVKKFLDPNSYSVNYTEIA 120  chicken
XP_972128     866 QQGLQKYLNSVLMNp-----------------------ILVSSLPARSFVDPANYCQPFGELA 905  red flour beetle
NP_001076277   97 QKGLQAYLNYITQHh-----------------------ILCSCELVKKFLDTNNYSANYTEIA 136  zebrafish
EDV29715       89 KQQLQVYVNVILEDp-----------------------FLSHCLTVKKFFDPTRYTIDFYDIA 128  Trichoplax adhaerens
XP_001640318   89 QQGLQNFMNFILGNp-----------------------LLARHISVKKFLDPVNYSENFQENA 128  starlet sea anemone
XP_392133      93 QIALQNYLNNILMNp-----------------------ILASSLPMKKFLDPDNYTAPLHEIA 132  honey bee
NP_610341      93 KQALQEYINAVLMNp-----------------------ILASSLPAKRFVDPESYSQSFHDHA 132  fruit fly
XP_001847003   93 LSALQEYLNQVLMNp-----------------------ILASSLPTKKFIDPDSYSTPFHDLA 132  southern house mosquito
XP_002124930   91 QNGLQVLLESVLSHp-----------------------GLAACDTVKKFLDPNNYNFNQTELS 130  Ciona intestinalis
CAF96010       93 RGDYRPTWTQLPSIpcfpapclsksswiptatqpitqkSPCSKSQCSSGQTSNGKSWSLSETW 155  spotted green pufferfish

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