Conserved Protein Domain Family
PX_UP2_fungi

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cd06869: PX_UP2_fungi 
The phosphoinositide binding Phox Homology domain of uncharacterized fungal proteins
The PX domain is a phosphoinositide (PI) binding module involved in targeting proteins to PI-enriched membranes. Members in this subfamily are uncharacterized fungal proteins containing a PX domain. PX domain harboring proteins have been implicated in highly diverse functions such as cell signaling, vesicular trafficking, protein sorting, lipid modification, cell polarity and division, activation of T and B cells, and cell survival. In addition to protein-lipid interaction, the PX domain may also be involved in protein-protein interaction.
Statistics
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PSSM-Id: 132779
View PSSM: cd06869
Aligned: 19 rows
Threshold Bit Score: 86.5675
Threshold Setting Gi: 6325354
Created: 10-Jul-2008
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative
Feature 1:putative phosphoinositide binding site [chemical binding site]
Evidence:
  • Comment:A majority of PX domain containing proteins binds phosphatidylinositol-3-phosphate (PI3P) at this site. In some cases, other phosphoinositides, such as PI4P or PI(3,4)P2, are the preferred substrates.
  • Comment:based on the structures of phosphatidylinositol-3-phosphate bound to other members of this superfamily
  • Comment:Two basic residues are key in binding with phosphoinositides: one forms hydrogen bonds with the 3-phosphate of PI(3)P and another forms hydrogen bonds with the 4-and 5-hydroxyl groups of PI(3)P.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                     ### 
Q9Y7N9        167 NILEAYVLGVRQSTQAkml-------------------------rtkRVYEYLIKVSYEEn---------TFFIARKYSD 212  fission yeast
XP_757343     220 SGFDINVVSVRNVITKgrl-------------------------rsrAHEEFIIRTRRGYgq-------pDIYVSRRYGD 267  Ustilago mayd...
XP_500371     296 NGLCVNVVGVREIRTKrmlsf---------------------lagdhVSAEYLIETKMEShe------grTVVVARTFHD 348  Yarrowia lipo...
XP_001837177  314 DYFEVNIVGVRTVVDKgrv-------------------------rskAHEEFIIRTRRAGy--------hDTYVSRRYGD 360  Coprinopsis c...
XP_387537     205 NGWDVNVAGVRVTQVKhti-------------------------rkhKHAEFILRIKKKGe--------lEHFVGRRYSD 251  Gibberella ze...
XP_001729542  192 FTTKVNIVCVRRTLSRgri-------------------------rhkTLDDFIIATHLNNd---------EIYVARRYKD 237  Malassezia gl...
XP_719297     189 GSNGLNIVAVRVIYENptnisswi----------------pfynrikVYHLFIVELQNDNq--------dTYYIAKSYQN 244  Candida albic...
XP_001383777  187 HNLSINIVALRRTGAAvagtpsnsisswsp----mrfvtssrpsaprHHYEFVIQVTTREsvdgn-fqykSHFIARHYHE 261  Pichia stipit...
XP_001524186  174 NDIYINIVAVRTVEHEqlrswf--------------------kvqrqHNYEFVIQIVLRQgke-----cvNVFVNKYYGQ 228  Lodderomyces ...
CAR65737      200 NDLNLNIVAVKHIKEQngsgsdsagasrwnifkevsrlspynsnpvrHNYEFVIQFTKREtdkegtyhytSYFIPRPYHD 279  Debaryomyces ...
Feature 1                                  ##                                                     
Q9Y7N9        213 FSHFHHLLLKSYPN---AYVPRLPPKDDhdtylnssedstlsplp----------------------------------- 254  fission yeast
XP_757343     268 FERLADSLKVEYPD---EGIRPPPPKDRsntdvadpyrrepasssqpatplpdg---------------------sdaac 323  Ustilago mayd...
XP_500371     349 FKELAKKLHREFPG---RGLPNLPVRNRaasqatssgiggfvdtenddpede------------------------lnda 401  Yarrowia lipo...
XP_001837177  361 FRTLANELAKRYPE---EDIKPPPAKDRsyvtapatpqtqsfseqlydaatgslgsaas-----------ylfddgshpa 426  Coprinopsis c...
XP_387537     252 FAKLHSRLRTELPG---RVVPEMPKKNKsdttttiaftsmfsngndsdassissvstrpngytsmlspghrkkdssasfr 328  Gibberella ze...
XP_001729542  238 FRQLHQQLRALFPT---EDLPDLPPKDMsstevqgslqpdsn-------------------------------------- 276  Malassezia gl...
XP_719297     245 FKTLHNKLKKKFPGl-fTEIHLPSHKDKhdngweinndkesla------------------------------------- 286  Candida albic...
XP_001383777  262 FKTLESKLKRHLPGvmsTEVSELPRKFSndngyndiahekdtese----------------------------------- 306  Pichia stipit...
XP_001524186  229 FRTLENELKKELPGamtTKIATLPHKEKhdegedld-------------------------------------------- 264  Lodderomyces ...
CAR65737      280 FKKLEHDLKKKYPGlmsTDVPKLPQKLKrddgvlkkrdfessqslprsdsfdtle-------------------ndnhdd 340  Debaryomyces ...
Feature 1                                  #                              
Q9Y7N9        255 ----srssdtndpqsdsqhvLRQERMRIELRQYIKNILNDDELHLTEEVLSFLTDD 306  fission yeast
XP_757343     324 srastesnssqtripiptgpLAREKNRLTLRAYLRSLLASPSVAESALLMDFLTAE 379  Ustilago maydis 521
XP_500371     402 eehiddddtanvhhdgkrvsLPREKQRTTLRAYLHTLVSNRMVANSKTLLEFLYMD 457  Yarrowia lipolytica CLIB122
XP_001837177  427 spvtpasshfpqspppnpakLAREKNRLTLRSYLHSLMSSSAIASSPVLKSFLLSG 482  Coprinopsis cinerea okayama7#130
XP_387537     329 snrskglnsprlpsprqtivLWRENQRISLRAFLRSLLHNPQFANTNAMQEFLSGE 384  Gibberella zeae PH-1
XP_001729542  277 -------eewtdltavtpnsLVRETNRLTLRAFLRSILAVPSVADSEIFQEFLTGD 325  Malassezia globosa CBS 7966
XP_719297     287 -----yeeeedttscsnekiLIREKMRLSLRGYLKSLMKIPEVAHCTILSEFLTTN 337  Candida albicans SC5314
XP_001383777  307 ----laslsstvngsskttkLVREKLRLSLRGYLRTLSKYPEIVHSDIFLDFIDHG 358  Pichia stipitis CBS 6054
XP_001524186  265 -------------mdgksgvLTRERLRLALRGYLRELIKVKEIVKTNAFQLFILTD 307  Lodderomyces elongisporus NRRL YB-4239
CAR65737      341 ssfktasssnstsatpepqsLAREKLRLALRGYLNNLIKHNEIIHSDVFHHFVFNP 396  Debaryomyces hansenii

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