Conserved Protein Domain Family
PX_SNX4

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cd06864: PX_SNX4 
The phosphoinositide binding Phox Homology domain of Sorting Nexin 4
The PX domain is a phosphoinositide (PI) binding module present in many proteins with diverse functions. Sorting nexins (SNXs) make up the largest group among PX domain containing proteins. They are involved in regulating membrane traffic and protein sorting in the endosomal system. The PX domain of SNXs binds PIs and targets the protein to PI-enriched membranes. SNXs differ from each other in PI-binding specificity and affinity, and the presence of other protein-protein interaction domains, which help determine subcellular localization and specific function in the endocytic pathway. SNX4 is involved in recycling traffic from the sorting endosome (post-Golgi endosome) back to the late Golgi. It shows a similar domain architecture as SNX1-2, among others, containing a Bin/Amphiphysin/Rvs (BAR) domain, which detects membrane curvature, C-terminal to the PX domain. SNX4 is implicated in the regulation of plasma membrane receptor trafficking and interacts with receptors for EGF, insulin, platelet-derived growth factor and the long form of the leptin receptor.
Statistics
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PSSM-Id: 132774
View PSSM: cd06864
Aligned: 10 rows
Threshold Bit Score: 202.984
Threshold Setting Gi: 195999222
Created: 10-Jul-2008
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
phosphoinosit..
Feature 1:phosphoinositide binding site [chemical binding site]
Evidence:
  • Comment:A majority of PX domain containing proteins binds phosphatidylinositol-3-phosphate (PI3P) at this site. In some cases, other phosphoinositides, such as PI4P or PI(3,4)P2, are the preferred substrates.
  • Comment:based on the structures of phosphatidylinositol-3-phosphate bound to other members of this superfamily
  • Comment:Two basic residues are key in binding with phosphoinositides: one forms hydrogen bonds with the 3-phosphate of PI(3)P and another forms hydrogen bonds with the 4-and 5-hydroxyl groups of PI(3)P.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                           ###                       ## 
XP_422107     42 MEITVSEAEKRTGRnamnmqETYTAYLIETRAVesqne--gqcspVDSLWRRYSEFELLRNYLLVTYPHIVVPPLPEKRa 119 chicken
Q5R4C2        58 IEISVSEAEKRTGRnamnmqETYTAYLIETRSIehtdg---qsvlTDSLWRRYSEFELLRSYLLVYYPHIVVPPLPEKRa 134 Sumatran orangutan
CAQ14831      41 MEISVAEAEKRTGKnavnmqETYTVYLIETRPVdaase--gtspvPDSLWRRYSEFELLRNYLLVTYPFVVVPPLPEKRa 118 zebrafish
XP_970429     27 LEISVAESEKRANGtln-lrEFYTVYLIETKSVltdsefqnkfpkLTTVWRRYTEFEQLRGYLEVTYPYIILPPLPEKRv 105 red flour beetle
XP_785792     47 VEINVTEQEKRTGNaamgikDVYTVYLVETCRVkdnsniakltmdSSSLWRRYSEFELLRNYLVVTFPHVVLPPLPEKRm 126 purple urchin
XP_001948366  14 ASIGITEADKRMNSals-lkEYYTVYIIETKIDsetwaetkgmqkLSLATRRYTDFVTLHNHLGDKYPWVVIPPLPEKKq 92  pea aphid
XP_001626045  25 MILSITDSEKRASEyi---kEPFTVYLIESKYIdggppa-gdpdmSCNLWRRYSEFELLRNYLVATYPAVIVPPLPEKRi 100 starlet sea ane...
XP_002119505  42 FKITVSDPEKRTKPsgikmqETFVVYLIETTPKnaess---lieeVTSLWRRYSEFELLRNYLVVIYPAVIVPPLPEKRa 118 Ciona intestinalis
EEC15657      16 VEITITDTERRCAGsavplqDIYVAYQVESVIRepe-------ktPYIVWRRYSDFEVLHSHLQDSFPYVIIPPLPERKv 88  black-legged tick
XP_002109479   1 MDITVTEPEKRVVNtdm-lkDTFMVYLVQTKCTghggpd-dfekgTHSVWRRYSEFDLLRNYFNVTYPYIIIPPIPEKKl 78  Trichoplax adha...
Feature 1                              #                              
XP_422107    120 dfvw---hklsaDNMDPDFVERRRIGLENFLLRVASHPVLCQDKIFYSFLTQE 169 chicken
Q5R4C2       135 efvw---hklsaDNMDPDFVERRRIGLENFLLRIASHPLLCRDKIFYLFLTQE 184 Sumatran orangutan
CAQ14831     119 efvw---hklsaDNMDPDFVERRRVGLENFLLRVASHPVLARDNIFYLFLTEE 168 zebrafish
XP_970429    106 mfgw---qkissDTFDPNFVDRRRAGLENFLLRVASHPVLSWDKHFIEFLQHE 155 red flour beetle
XP_785792    127 mamwq--qlatvDNFDADFVERRRVALEGFLQRVAAHPLLCQDELFHGFLQDA 177 purple urchin
XP_001948366  93 sfmwn--seavsDTMDPDFVDRRRAGLESFLKRIAGHSEIGYDECFLKFLGEC 143 pea aphid
XP_001626045 101 nlsa---lrlaaDKFDPDFIEKRRTGLENFLLRCAAHGQLSQDPIFLGFLNMV 150 starlet sea anemone
XP_002119505 119 nfiwn--kitatDTFDIDFLERRRAGLESFLHRIAGHRKLGKDKIVKHFITKE 169 Ciona intestinalis
EEC15657      89 myrw---qklpsDRLDPDFVERRRASLELFLRRVAGHPELCTNVLFLEFLKHE 138 black-legged tick
XP_002109479  79 psfhmswknittDTFDQDFIERRRSGLEAFLHRVAQHPTLCQDRIFHSFLQKE 131 Trichoplax adhaerens

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