Conserved Protein Domain Family
GT_WbpL_WbcO_like

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cd06854: GT_WbpL_WbcO_like 
The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor. The WbcO/WbpL substrate specificity has not yet been determined, but the structure of their biosynthetic end products implies that UDP-N-acetyl-D-fucosamine (UDP-FucNAc) and/or UDPN-acetyl-D-quinosamine (UDP-QuiNAc) are used. The subgroup of bacterial UDP-HexNAc:polyprenol-P HexNAc-1-P transferases includes the WbcO protein from Yersinia enterocolitica and the WbpL protein from Pseudomonas aeruginosa. These transferases initiate LPS O-antigen biosynthesis. Similar to other GlcNAc/MurNAc-1-P transferase family members, WbpL is a highly hydrophobic protein possessing 11 predicted transmembrane segments.
Statistics
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PSSM-Id: 133464
View PSSM: cd06854
Aligned: 44 rows
Threshold Bit Score: 187.836
Threshold Setting Gi: 197627253
Created: 27-Oct-2008
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
Mg++ bindingputativeputative
Feature 1:Mg++ binding site [ion binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                ##      
Q56918        31 IIDTPNSRSSHVtPTPRGGGVAIvisfligiilfyflg-----------ylpilsvvglivsgGVIALVGFWDDhghiaa 99  Yersinia entero...
ZP_01052742   27 IIDKPNQRSSHTkITVRGGGIIFpiaillfyiih------------------dftysyftlgiFLIAIVSFLDDiytlss 88  Polaribacter do...
ZP_01717387   28 IIDIPNNRSSHTiPTVRGGGILFptavilwwmaf------------------dfqntwmiigiLWVAAISLLDDlyslsr 89  Algoriphagus sp...
YP_001529184  32 LLDRPGHRSSHSqTTPKGGGIGLlaafvlcslgv-------------------gvpagfwipaVVVSGASFLNDrremgi 92  Desulfococcus o...
ZP_01883705   26 IVDRPNERSSHTvLTIRGGGVIYlfaalvalvmh-------------------paywmfisglFIIGVISFIDDritlss 86  Pedobacter sp. ...
NP_808969     28 IIDRPNQRSSHKkNVLRGGGIIFllgvwmyafln------------------ttgyplfiggmTLIASVAFIDDvcslsp 89  Bacteroides the...
ZP_01202887   27 IVDKPNHRSSHTkVTIRGGGIIFfigalfffltt------------------glqypfffaglTILAVVSFIDDlislsa 88  Flavobacteria b...
NP_809309     27 IIDKPNERSSHStIVLRGGGILFlinawvwsaff------------------gfqypwflaglTLVAGVSFVDDihslpd 88  Bacteroides the...
YP_001624589  33 VVDMPSERSSHSvPTIRGMGISVlaavslallvslftpl---------sanhkaiiltilivvLAASIVGWAEDlrglrv 103 Renibacterium s...
YP_001838140  30 VKDVPNERSLHDtVTKKSGGMFFiplflvasllfhfnpewahpllenpslipkdnfylllvgiFIFSILGFVDDlyhltp 109 Leptospira bifl...
Feature 1                                                                                        
Q56918       100 rWRLLAHFSAAAFllfcfggfpvlnvsgfiielgifgslfgLLFLVWMLNLYNFMDGIDGLASAEAVTACIgmiaiyyis 179 Yersinia entero...
ZP_01052742   89 kIRFPFQFIAVFLilleiglpy----------spiymycaaLLFGVGIINMFNFMDGINGITGLYSLSVLLgfyflnene 158 Polaribacter do...
ZP_01717387   90 sIRFGVQFLAVSLafydldlfnq---------vswmalpifYFLALGTINAVNFMDGINGLTGLYSLVFMGsmlavnvyt 160 Algoriphagus sp...
YP_001529184  93 kWRLGIQFLAAGLflaacaipgfdsl---sfgafiglalfyAVFVAGTANYYNFMDGINGIAAITGMVGFGllaaygyma 169 Desulfococcus o...
ZP_01883705   87 kLRILFHLIAVTLslwsanvfna---------ypwwvipllYILMIGIINAYNFMDGINGITGLYSLVLLFgvqfvnyrv 157 Pedobacter sp. ...
NP_808969     90 rFRFFVQFVAMFLllqeagmlve---------nkvwfllptMILGVCIINAYNFMDGINGMTGAFSLMVLFtfwllnrem 160 Bacteroides the...
ZP_01202887   89 lLRFSAQVIACLLliyqsvyey-----------nlifllflLIAAIAFVNAYNFMDGINGITGIYSIGVLSsliyidlyi 157 Flavobacteria b...
NP_809309     89 sVRLVAQFVAASMafyqldilhw---------smwwiillsLIIYVGATNVINFMDGINGITAGYALAVLVtlalvnmng 159 Bacteroides the...
YP_001624589 104 tNRAAFHLIIGAAgtavlawltg--------gtgywwapagAVAVAAYINVANFMDGINGISGLHGAVVGAayaiagalt 175 Renibacterium s...
YP_001838140 110 kLRLVLEFGIVFIclwgihptitafg--fveipwvaeilflTIFLVFGINLVNFMDGMDWYLVLTFFICFFsiglvlpnf 187 Leptospira bifl...
Feature 1                                                                                        
Q56918       180 gdhielnsflvlwllacTVLGFLLWNFPPAk---IFMGDAGSGFLGLMIGSLAIsagwidtrf---------ffcwlill 247 Yersinia entero...
ZP_01052742  159 ql----lqsdliiysiiALLIFGFYNFRTKa--lFFAGDIGSIAIGALVFFTGLyfmyyles-----------plillfv 221 Polaribacter do...
ZP_01717387  161 pi----fdreliqyeilAISVFLIFNFRKKa--mMFAGDIGSITIAYLMIYFLTkwylevqs-----------wtvllfl 223 Algoriphagus sp...
YP_001529184 170 gkp--dalwcaslgmvfACAGFLPFNIPGAq---VFMGDVGSVLLGFVFAALVVafsaspaef----------vacagfl 234 Desulfococcus o...
ZP_01883705  158 vsf---vnpdliwlpilASLVFLFFILEEAr---CFAGDVGSVSIAFWIVTLLIililkaad-----------yryilfl 220 Pedobacter sp. ...
NP_808969    161 af----idatliellmiSALVFCFFNFRNQa--iCFAGDVGSVGMAYCVIFILLklvlftgn-----------vtyllfl 223 Bacteroides the...
ZP_01202887  158 ydf---ieedlliytliSVIIFGYFNFRKKa--iFFAGDIGSVTLAFILVFAAYqlliatds-----------pyvlllf 221 Flavobacteria b...
NP_809309    160 vf----veqsliistilASLVFCFFNFRPRgkarCFAGDVGSIGIAFIMLFLLGnviikttd-----------itwlifl 224 Bacteroides the...
YP_001624589 176 qtp---wlvvvgvviaaGFIGFLPWNLSGKp---VFLGDVGSYLLGSSIAITAVaaflagvpv----------eylfapv 239 Renibacterium s...
YP_001838140 188 ysip-nfgfslyvilllSMFGFIVYNFPKAk---LFMGDSGSLALGFFVLVLPLlhhsklqnqitkegvfwdltdyfylf 263 Leptospira bifl...
Feature 1                                                    
Q56918       248 gLFIVDATWTLVRRvlgg-fkvYEAHRSHGYQIASRRFKRHLPV 290 Yersinia enterocolitica
ZP_01052742  222 iVYGADAGNTLLYRkfftqesiFEAHRHHIYQKLVDKTRFTHLQ 265 Polaribacter dokdonensis MED152
ZP_01717387  224 lVYGADSMLTIIQRllkk-envLKPHRLHLYQILANEGKNDHVL 266 Algoriphagus sp. PR1
YP_001529184 235 fPFYADELFTLVERvkag-ekiTHAHRRHLYQVLANELGVAHWK 277 Desulfococcus oleovorans Hxd3
ZP_01883705  221 aVYGVDAVLTIIHRlylr-qniFEAHRLHFYQLLANEQKIPHLL 263 Pedobacter sp. BAL39
NP_808969    224 vVYGIDTVLTIFHRlllh-enlLQPHRKHLFQLLANEGGHSHVT 266 Bacteroides thetaiotaomicron VPI-5482
ZP_01202887  222 iVYGTDSLMTILKRfylk-eklSEPHRHHIYQQLTDVKKIGHIK 264 Flavobacteria bacterium BBFL7
NP_809309    225 lVYGVDGCLTIAHRimlh-enlGEAHRKHAYQIMANELKIGHVK 267 Bacteroides thetaiotaomicron VPI-5482
YP_001624589 240 lIYLADTFVTLIRRmaag-erwYVAHRQHAYQRVVIVGLSHLQA 282 Renibacterium salmoninarum ATCC 33209
YP_001838140 264 pFFWIDGITILIKRflqk-khlFQAHREHLYQKLTETKLGKIGS 306 Leptospira biflexa serovar Patoc strain 'Patoc 1 (P...

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