Conserved Protein Domain Family
GT_WecA_like

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cd06853: GT_WecA_like 
This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate molecule and N-acetylglucosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylglucosamine precursor. WecA participates in the biosynthesis of O antigen LPS in many enteric bacteria and is also involved in the biosynthesis of enterobacterial common antigen. A conserved short sequence motif and a conserved arginine at a cytosolic loop of this integral membrane protein were shown to be critical in recognition of substrate UDP-N-acetylglucosamine.
Statistics
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PSSM-Id: 133463
View PSSM: cd06853
Aligned: 137 rows
Threshold Bit Score: 97.5592
Threshold Setting Gi: 29831026
Created: 29-Oct-2008
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
Mg++ bindingputativesubstrate
Feature 1:Mg++ binding site [ion binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                          ##            
ZP_01666735   38 RKVHThPIPRLGGLAIYLGFVLavlasmh----------------vnreimgLLMGGTVILVVGIIDDlkQLPARVKLLG 101 Thermosinus car...
YP_356905     40 RKVHVrPKPRLGGVAIFIAFLFamlvfdd----------------igrqvkgILAGSLIMFATGLVDDlyGLSAKKKFMG 103 Pelobacter carb...
ZP_01388610   40 RKVHCdETPRLGGIAIFSAFLFstlffcd----------------idrqikgFLSGAVIIFLTGLADDltNLSPKQKFLG 103 Geobacter sp. F...
ZP_01452986   45 RKVHVnVVPRMGGLAFLVSLLLipftmld----------------vstttqgFLLGLFIIGFTGMADDifQISPRLKFLG 108 Mariprofundus f...
YP_679477     45 RKQHKePIPTMGGVGIFAGLIVsgfiwidl--------------lsvresigISVAISMLLVTGIVDDikGLSAVFRLGI 110 Cytophaga hutch...
YP_001301706  41 RKVHTmPVPRLGGLSFFPVILMsmflvigfrlyfwdvnvsglsfnmlyeylfLFVGMTLLYLVGVCDDlvGVGYRYKFAV 120 Parabacteroides...
YP_001298032  43 RKLHTaHIPRLGGIAFFPCITVtvslaiigynlwqg--ynildmdltnrllsMLCCLFILYLIGMMDDliGVRYRSKFVV 120 Bacteroides vul...
YP_001231791  37 RRAHKkVTPRWGGVAFFVGVLPfmfmene-----------------sgaltsFIVASCFLVGMGIIDDlkSLGWKTKFAG 99  Geobacter urani...
NP_811800     25 RKTHSgIVPRLGGVVFVPVQCFllvlsmffmykleit-sylqdpfipfqfllLMIGLLILNMVGVIDDliRINYRRKFVA 103 Bacteroides the...
NP_904452     58 RTVHKgAIPRLGGVIFFPVITLtvslflainsvlri--sihfpleefydllfLLPAMILLYAIGVIDDlvGLSYRQKFKA 135 Porphyromonas g...
Feature 1                                                                                        
ZP_01666735  102 QIVAAMVLLlfnvriewltnp---fgdmiyldyfsIPLTILWVVGLTNTVNLIDGLDGLAAGVSTIASItillvalqqnf 178 Thermosinus car...
YP_356905    104 EIFGCLVTIavgnlyitslgnifgtgviemptwlgIPFTVFAIVGVINALNLLDGLDGLAGGFAAVALGtfillgyldgn 183 Pelobacter carb...
ZP_01388610  104 EIIAAAVAVivgglelsslgnp-fglgqitlgplaIPFTIFAVVGVTNAVNLLDGLDGLAAGGTAIACLafgtlayqtgn 182 Geobacter sp. F...
ZP_01452986  109 IIAGCGMFLvmsgtaitdlgnl-fgsghietgwfaIPLTLIAMVGFVNALNLSDGLDGLAAGITLIASFflgsfaliigd 187 Mariprofundus f...
YP_679477    111 QCIGGVLAIqaglvihlpsif---qfsvetmmiieYGVTIFLIAGVTNAFNLIDGIDGLAGGLGFINASmfgflflyfgn 187 Cytophaga hutch...
YP_001301706 121 QIAAAFLLVlsgnwfdsfggl---fgiysvpvwvgVPFTVFIVVYITNAINLIDGIDGLASGLCCIALSvlsvifflrgq 197 Parabacteroides...
YP_001298032 121 QILCGILLVisglcfdnlygl---fgiyvipyyigVPFTVFVIVYILNAINLIDGIDGLASGLSIISFLafscmfihlqw 197 Bacteroides vul...
YP_001231791 100 MAIAATIVIfggniavhhigty-gslgrldlgrlsIPFTYLSIIGITNAINLLDGLNGLAGGVSLLGFLfmgiaaviagn 178 Geobacter urani...
NP_811800    104 QIVASSFLPlsglwindlygl---lgittlspwigMPLTVFVAVFIINAVNLIDGIDGLCSGLVGMGALvfgflfiynaa 180 Bacteroides the...
NP_904452    136 QILSSSILFlsgvslsgldgl---lfieelpkilqYPIVVFFFLMVINSINLIDGIDGLATSLVLLGMLfyipffiyvnm 212 Porphyromonas g...
Feature 1                                                                                        
ZP_01666735  179 wtvailtaaLAGSALGFLYHNFNPAk-----IFMGDTGSMFLGYMLAAVSIlgtvks-----aatiaLVVPIVALGLPIM 248 Thermosinus car...
YP_356905    184 mvvvslcaaLVGGIFGFLRFNVYPAr-----IFMGDAGSLTVGFLLGFLAIfltqas-----gstvqPVIPFIILGLPII 253 Pelobacter carb...
ZP_01388610  183 hsllaldaaLLAAIVGFLRYNTYPAt-----IFMGDSGSLFLGYCMGIFSVmlvtta-----aaeisVFVPLVVLAVPII 252 Geobacter sp. F...
ZP_01452986  188 deslmidvvLFGSMVGFLYFNSHPAr-----IFMGDTGSLILGYVLACLSLmllqsg----rgevisPISMGILLGLPLS 258 Mariprofundus f...
YP_679477    188 tgfavlsfsFAAALLAFLKYNFNPAr-----IFMGDTGSLVLGYLMIVFAIkvfnlsya-hthsntfILLVFSIVLVPVI 261 Cytophaga hutch...
YP_001301706 198 yvyallaicTLGILMPFWCYNVFGNanrghkLFMGDAGSLTLGYVISFLIIhmsvtnevsptlsnpyMVIAFSTVLVPLL 277 Parabacteroides...
YP_001298032 198 wmyafislaAFSVLLPFFYYNVYGKiyrgrkIFMGDTGSLTIGMLLAVMVIrlsmsdpvkesafpgsIVIAFSFLIVPML 277 Bacteroides vul...
YP_001231791 179 ivvalvcfaFVGALGAFLLYNFPNAr-----IFMGDSGSTFLGFSLSIMAVfltqda-----nssvdSMFPVLVLLIPIF 248 Geobacter urani...
NP_811800    181 wlhavfafiTAGVLCPFFYYNVFGKskgrqrIFMGDTGSLTLGLSMAFLAIsyamnnplikpfsegaIVVSFATLIVPLF 260 Bacteroides the...
NP_904452    213 ylyviicvsVIGCLGAFLRMNLYGTtekrtkIFMGDTGSLTLGLLLSFMALrlltpi----antalpLPYVVAPLLIPCF 288 Porphyromonas g...
Feature 1                                         
ZP_01666735  249 DTAFAIIRRyssgqpIFKPDKGHLHHRLLAMGL 281 Thermosinus carboxydivorans Nor1
YP_356905    254 DTVRVMGERlmrrgnPFLPDRTHVHHRFLDLGF 286 Pelobacter carbinolicus DSM 2380
ZP_01388610  253 DTLVVMSNRlfkgkkIFSPDKSHIHHRLLDLGI 285 Geobacter sp. FRC-32
ZP_01452986  259 DTIYVMVRRilrgtsPFLPDKTHFHHRLIDLGL 291 Mariprofundus ferrooxydans PV-1
YP_679477    262 DTARVFLFRilkgksPFSADRSHIHHLLLKTGF 294 Cytophaga hutchinsonii ATCC 33406
YP_001301706 278 DVIRVVLHRlrehknPFLPDKNHFHHKLLRTGM 310 Parabacteroides distasonis ATCC 8503
YP_001298032 278 DVIRVVIHRlrngknPFLPDRNHIHHKFIALGM 310 Bacteroides vulgatus ATCC 8482
YP_001231791 249 DTLRVLFVRllngknPFQADNLHLHYLIVENLS 281 Geobacter uraniireducens Rf4
NP_811800    261 DVVRVVRIRyfqhkpLFMPDQNHIHHKFLRVGM 293 Bacteroides thetaiotaomicron VPI-5482
NP_904452    289 DLFHVFVLRilskknPFKPDKSHIHHRLMALGL 321 Porphyromonas gingivalis W83

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