Conserved Protein Domain Family
GT_MraY

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cd06852: GT_MraY 
Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of undecaprenyl-pyrophosphoryl-N-acetylmuramoyl-pentapeptide from UDP-MurNAc-pentapeptide and undecaprenyl-phosphate. It is an integral membrane protein with possibly ten transmembrane domains.
Statistics
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PSSM-Id: 133462
View PSSM: cd06852
Aligned: 134 rows
Threshold Bit Score: 203.488
Threshold Setting Gi: 210613091
Created: 21-Jul-2008
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
Mg++ bindingputativeputative
Feature 1:Mg++ binding site [ion binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                    ##                  
Q6AJ51        61 GPETHFKKKGVPTMGGLLILLSVTVSTLLWarld------nplIWLVLLVTLFFGMIGAYDDYKKiskk---tseGLSAK 131 Desulfotalea ps...
YP_002250974  39 GPSSHFQKSGTPVMGGIVFILAVFPFLFFKe------------TFFISLSTILFGLLGLVDDLKLmen----kdyGIRPL 102 Dictyoglomus th...
ZP_03037367   39 LPPDHQAKRGTPLMAGLILLIGIGMSLQFQpt---------plTVFLCSTFLLFSSIGFMDDFKKaawq---dpsGISGR 106 Geobacillus sp....
NP_295558     33 GPQTHLAKEGTPTAGGVAFVLALLLVFVGLlafggigqanlsrEVMILLAALGMGVVGGIDDFLKirsrkfggkkELLAR 112 Deinococcus rad...
ZP_03134972   32 GPRSHLAKEGTPSMGGVAFLLAAFLAYWALgm---------dgLRGLWLLGLGFALLGLLDDLSGsl------krPLRAR 96  Thermus aquatic...
ZP_03331267   39 GPDLHNYKTGTPTAAGLVFIPIFIAVLLNFnrg--------peSFLIAFSALSYGLIGAIDDFMKikrk---nasGITAV 107 Thermotogales b...
NP_972849     56 FTVNPEAAVGKPTGGGVVFISIFVLCVFLLiip-------tltQGLVLVITFAVMLTGFLDDRSEk---------SWGEY 119 Treponema denti...
ZP_02092705   45 FAVNGELSKGKARGSGLIFVLCIALVSLAFlpf-------tteYVVYNVLLIASMLSGYLDDAAEt---------AWNEY 108 Faecalibacteriu...
ZP_03289607   46 FAINGKLSKGKIRGVGLTFVLCFIISSILFlpi-------dreYIIYLILLFCVMLSGYLDDAADt---------PWSDY 109 Clostridium nex...
NP_218785     67 FAPCAQEAAGKPTGAGVIFVSVFVLLVYLLmrp-------sfvHALILLLTWGVMLTGYLDDCAQv---------CWGEY 130 Treponema palli...
Feature 1                                                                                        
Q6AJ51       132 GKLLLQIAGALIVGFFVYlhpgydgqlsi-pfmknvqpdlgWFYIVFAVIVIVGASNAVNLTDGLDGLAAGPMVVSSAVY 210 Desulfotalea ps...
YP_002250974 103 RKIFLSFIITLILYVFSPhdykiywg-------shliidssILYIFLFFIILIAVPNAINLTDGLDGLAGGTSLVTLIFL 175 Dictyoglomus th...
ZP_03037367  107 TKLVLQFLFTGALLYVLFqsfsltsdial--fngfqlhlpiSVYIVIMLLFIVGSANAINFTDGLDGLLINVAIPTYFFF 184 Geobacillus sp....
NP_295558    113 EKFPLQVLVALLFAGFAAplashqllp-----gfmsiggypIFDMLFIAFVMVGSVNAFNFTDGLDGLLAGVGMIVLLPL 187 Deinococcus rad...
ZP_03134972   97 EKLFFQTLMALVFALWAVrqvay--------------tpwpILDVLLILLAVVGAANAFNFTDGLDGLLASLTAVLLIPF 162 Thermus aquatic...
ZP_03331267  108 QKLFMQFTAAFIIVYFIQqinphtyliv---pfsgykldlgWFYYLLSSVVIVGVSNAVNLTDGVDGLAGFVFIGSIVPL 184 Thermotogales b...
NP_972849    120 LKGGLDFILSAVTALVIFyiyfegkvsfwlpfisnlvevhpIVFFVVSIMILWISINTTNCTDGVDGLSGTLILLALVSL 199 Treponema denti...
ZP_02092705  109 KKGIIDFVIAVLAGVTYLnfngcgvhf-----lqwsftlpyAVYLLLIVILIWASINVVNCTDGVDGLSASLAVVTIGTY 183 Faecalibacteriu...
ZP_03289607  110 KKGFIDLIISIVTMLTFVnynttvihf-----fetelvipkAVYVILGIILIWVSINVTNCSDGVDGLCASLCTVSLISF 184 Clostridium nex...
NP_218785    131 RKGALDFLFAVLTAALLGhfyfhdqvfwwfpffsdpvfvspFLFFAGSVVILWMSINATNCTDGVDGLSGALVLMALLSM 210 Treponema palli...
Feature 1                                                                                        
Q6AJ51       211 LLFAYlagnvvlanylhip-yvagsgelaifcgTLFGACLGFLWFNAHPAQMFMGDVGSLALGGALGSIAIIIKqefLLA 289 Desulfotalea ps...
YP_002250974 176 LVYSFhfkki------------------aleisLMITALLAFLWFNSHPAEIFMGDVGAFALGGFIASLSVVNKvelLLI 237 Dictyoglomus th...
ZP_03037367  185 FLISDkpevq-------------------mfslVMIGCLLGLLLYNIHPARAFMGDTGSLAIGGSLSFLAVIEKveiLIP 245 Geobacillus sp....
NP_295558    188 VAVSPia-------------------------aLMVAVLLGFLWFNAHPARVFMGDMGSHAIGAVAAGAYALYSdvwLLP 242 Deinococcus rad...
ZP_03134972  163 YPLPLa--------------------------qTLLGGVLGFLWHNAPKAKVFMGDTGSQALGAMVAGLFILTGklwLLP 216 Thermus aquatic...
ZP_03331267  185 LIVGYqsv----------------------vylSLIGLLMGFLWHNWHPASIFMGDAGSLALGGILATSFALNGlelFLI 242 Thermotogales b...
NP_972849    200 GIVFYfvlghvkvaayllvpnistgakwavmifTLCGVLTGYLWHNAYPSKVLMGDAGSRALGFFIGVLVIISRnpfILL 279 Treponema denti...
ZP_02092705  184 LLAYKtelgay-----------------atagvVFIGALLAYLWLNAKPSSLLMGDAGSRAMGFFIAMLSLKCGhpfAFL 246 Faecalibacteriu...
ZP_03289607  185 SLIFKdvlgmy-----------------tnanfLFVAVLLAYLYFNTSPSSMLMGDAGSRALGFYLAIITVKSGhpfLYI 247 Clostridium nex...
NP_218785    211 GTIFYfllgnvraaqyllvpfvvdgaqwalmsfALAGALMGYVWRNAHPSTVLMGDAGSRALGFFIGVLVLISGnpfLLL 290 Treponema palli...
Feature 1                                                                            
Q6AJ51       290 IVGGVFVMEALSVMLQVGYFRms-kgKRIFLMAPFHHHFEk-kGWSEPKVVVRFWIVSIILGLFAIAT 355 Desulfotalea psychrophila L...
YP_002250974 238 FLSGIFLIESLSVFIQVFFYKwk--kKRIFLMSPIHHHFEl-kGWKETKIVWRFYIIHLLIIIGGLVL 302 Dictyoglomus thermophilum H...
ZP_03037367  246 LLFLIYLAEQLSVILQVWYYKrt--kLRLFRMAPIHFHFSlkyGWSENKIVMIFGFVSWFMALLCWVL 311 Geobacillus sp. Y412MC10
NP_295558    243 IAAIIPVAAVLSVVIQVASVRlr--kRKVFKMSPIQHHFEl-sGWPETHVTLRFWVVTGIATALTWWL 307 Deinococcus radiodurans R1
ZP_03134972  217 LAAIVPVLEVLSVVAQVLYFRkt--gRRLLRMSPLHHHFEl-iGWEEAKIVFRFAILTGLATALAFGG 281 Thermus aquaticus Y51MC23
ZP_03331267  243 FFGFIFLLETLSVIIQVTSFKfr--gKRVFRMSPIHHHFEl-lGWKEEKIAFRFSTLALLVSLLGIIG 307 Thermotogales bacterium TBF...
NP_972849    280 MTSCVILINGGTGILKVVMLRffkirIFKNIRFPLHDHMKknlQWSPTQVLIRFVIVQILITIVILGI 347 Treponema denticola ATCC 35405
ZP_02092705  247 LAAIVFIADGSLGILKISLKRflhiwILKNTLTPLHDHVRkrkGWSDEQVVARWLILQCVASALLLLL 314 Faecalibacterium prausnitzi...
ZP_03289607  248 LLAAVLIVDGGLGLVKIFLKRflkisILKNTRTPIHDHLRknhNWSDTQVVIRFIIIQVICSVLAFLL 315 Clostridium nexile DSM 1787
NP_218785    291 MTSGVILVNGGTGLLKVVLLRffhvrILSRVRFPLHDHMRenwHWSTAQVLLRFMILQGLLTIGLLGV 358 Treponema pallidum subsp. p...

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