2EJM,2DN8,3BG3,3BG5,2D5D,1DCZ,2QF7,1Z6H,2JKU,1BDO


Conserved Protein Domain Family
biotinyl_domain

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cd06850: biotinyl_domain 
Click on image for an interactive view with Cn3D
The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, oxaloacetate decarboxylase, methylmalonyl-CoA decarboxylase, transcarboxylase and urea amidolyase. This domain functions in transferring CO2 from one subsite to another, allowing carboxylation, decarboxylation, or transcarboxylation. During this process, biotin is covalently attached to a specific lysine.
Statistics
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PSSM-Id: 133459
View PSSM: cd06850
Aligned: 556 rows
Threshold Bit Score: 48.1812
Threshold Setting Gi: 28870097
Created: 29-Sep-2008
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
biotinylationcarboxyltrans..
Conserved site include 1 residue -Click on image for an interactive view with Cn3D
Feature 1:biotinylation site [posttranslational modification site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                 #                                       
2EJM_A         16 GPLAPmTGTIEk-------VFVKaGDKVKAGDSLMVMIAMKMEHTIKSP-KDGTVKKVFYRe--------GAQANrHTPL 79   human
1BDO_A          6 IVRSPmVGTFYrtpspdakAFIEvGQKVNVGDTLCIVEAMKMMNQIEAD-KSGTVKAILVEs--------GQPVEfDEPL 76   Escherichia coli
XP_681032     619 HIVLPlSGKLIe-------VLVLpGDIIEENQVVAFVKQMKMELERKSKvVNHFFDAYPLTd--------NLSSPpELIV 683  Aspergillus n...
XP_001597587  395 HIIAPfPGKLIe-------IYVEiGDKILAGQAICVIRQMKMEVEIRSK-KGGIVTWVLGDeeeeeewevGLDVR-EGVL 465  Sclerotinia s...
NP_795108     510 AVLTPvAGNLHt-------WVVEdGESVSAGQVIAVVEAMKMETSILAP-CAGDVNITQPA---------GTYFEaGSLI 572  Pseudomonas s...
EDP51504      566 HIVLPlSGKLIe-------VLVQpGETIAQDQVVAFVKQMKMELEVRSP-RAGHVTWVFEGsd-----geEDVVE-GMLL 631  Aspergillus f...
YP_971839     514 AVPAPvAGTVQa-------WKVTeGDTVAEGDVVAVMEAMKMEMQVTAP-RAGRIAGLVAV---------GSYQAaGAPL 576  Acidovorax av...
XP_001823475  448 QWLERhLGHVIq-------SGETiAQSVSENQVVAFVKQMKMELEVRSP-RGGRVRWVYQMde------eEEDVAeGMLL 513  Aspergillus o...
NP_931482     524 PVSAPiSGVLQs-------WYVQeGDEVKQGDVIAVMEAMKMETQLTAH-RSGKIVIYVEE---------GGYQQaGNVL 586  Photorhabdus ...
XP_001936878  437 HISIPfPGKLVe-------VLVDeGDVVKEGDVICVVQQMKMELEVRST-RSGLVTWVTDAe-------dGSNINeGTLA 501  Pyrenophora t...
Feature 1            
2EJM_A         80 VEF 82   human
1BDO_A         77 VVI 79   Escherichia coli
XP_681032     684 LSL 686  Aspergillus nidulans FGSC A4
XP_001597587  466 ILF 468  Sclerotinia sclerotiorum 1980
NP_795108     573 GRI 575  Pseudomonas syringae pv. tomato str. DC3000
EDP51504      632 VEL 634  Aspergillus fumigatus A1163
YP_971839     577 ARV 579  Acidovorax avenae subsp. citrulli AAC00-1
XP_001823475  514 VEL 516  Aspergillus oryzae RIB40
NP_931482     587 ASI 589  Photorhabdus luminescens subsp. laumondii TTO1
XP_001936878  502 AII 504  Pyrenophora tritici-repentis Pt-1C-BFP

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