1ZKO,2EDG,1ONL,1HPC


Conserved Protein Domain Family
GCS_H

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cd06848: GCS_H 
Click on image for an interactive view with Cn3D
Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and L-proteins) which catalyzes the oxidative cleavage of glycine. The H-protein shuttles the methylamine group of glycine from the P-protein (glycine dehydrogenase) to the T-protein (aminomethyltransferase) via a lipoyl group, attached to a completely conserved lysine residue.
Statistics
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PSSM-Id: 133457
View PSSM: cd06848
Aligned: 150 rows
Threshold Bit Score: 70.255
Threshold Setting Gi: 71030316
Created: 30-Sep-2008
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
lipoyl
Conserved site include 1 residue -Click on image for an interactive view with Cn3D
Feature 1:lipoyl attachment site [posttranslational modification site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                      #                 
1ZKO_A        18 YTK-THEWVSIedk------vaTVGITNHAQEQLGDVVYvDLPEv-GREVKKGEVVASIESVKAAADVYAPLSGKIVEVN 89  Thermotoga mari...
1HPC_A         9 YAP-SHEWVKHegs------vaTIGITDHAQDHLGEVVFvELPEp-GVSVTKGKGFGAVESVKATSDVNSPISGEVIEVN 80  pea
YP_001995047  15 YDSrYHFWAKPdptt----gnvVIGIDALGLDSAGELVYmSFHSa-GSRVRRHESLGSLEAAKMTGEILSPVSGTIIQRN 89  Chloroherpeton ...
YP_001196774   9 YTK-NHLWLRQvgl-----ydyFVGITDFAQKEIGEISLiELEFt-GEHMKKEMQWGKIYGLNQTFSLLAPIDCKVMATN 81  Flavobacterium ...
YP_846918    133 YHE-GHSWARIehg-----gfvRLGIDDFALRLLGSPTGiSLPKi-GTRLKRGENGWSIRREEHYASVLSPMDGTVMATN 205 Syntrophobacter...
YP_465210     70 YAP-GHVWLHRrpgg----ravELGLDGIAQRLMPAVTAvDLARp-GTRVARGDTIATLHGGGRALEIPAPVDGTVVGLN 143 Anaeromyxobacte...
YP_589846     58 YHP-GHTWALSesp-----nlvRVGIDDFAGKINGTVDKiNLPQr-GQWVRQGQKIWSIEKDGKKVDMVSPIEGSVAEIN 130 Acidobacteria b...
YP_001381440  68 YAP-NHTWLASaag------glRVGLDDFAQRLIPSTSAvDLPRp-GTQVRRGEPVAVVHAGGRSIRIGAPVDGVVVARN 139 Anaeromyxobacte...
YP_592020     55 FHP-GHTWVADegh-----qnaRVGMDSFAAQLFGKIDRiETVEl-NRWVRQGQKLWTVTHNGTSVDMLSPIEGVVVSLN 127 Acidobacteria b...
YP_701796     12 FTA-THSWLALapgqsfsdyplRAGVTDTALDEVEVVGL-ELPTvrSTIEAGAPCALVWTSARTVVTVYAPISGLVTMTN 89  Rhodococcus sp....
Feature 1                               
1ZKO_A        90 EKLDTEPeLINKDpegEGWLFKX 112 Thermotoga maritima
1HPC_A        81 TGLTGKPgLINSSpyeDGWMIKI 103 pea
YP_001995047  90 TNVLEEPsIVNAEpygRGWFVLI 112 Chloroherpeton thalassium ATCC 35110
YP_001196774  82 VILDTNPsSINRDp-yNNWFLRV 103 Flavobacterium johnsoniae UW101
YP_846918    206 QSASKQPgLSKKDpygEGWLIVV 228 Syntrophobacter fumaroxidans MPOB
YP_465210    144 VSVVRDPaLVKREgygRGWLVAL 166 Anaeromyxobacter dehalogenans 2CP-C
YP_589846    131 DAVLANPgLASKDpygEGWMITV 153 Acidobacteria bacterium Ellin345
YP_001381440 140 GAVRRDPsLVKLEpygRGWLFTI 162 Anaeromyxobacter sp. Fw109-5
YP_592020    128 HQVIKNPsSVGSDpykDGWVCVV 150 Acidobacteria bacterium Ellin345
YP_701796     90 TDAAENPqLVADDpfhRGWLFAV 112 Rhodococcus sp. RHA1

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