1HPC,1ONL,1ZKO,2EDG,3A7A,3A8I,3HGB,3KLR,3MXU,3TZU


Conserved Protein Domain Family
lipoyl_attach_GCS_H
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cd06848: lipoyl_attach_GCS_H (This model is not part of the current CDD release)
lipoyl attachment domain found in glycine cleavage system H protein and similar proteins
Glycine cleavage system H proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex, consisting of 4 different components (P-, H-, T- and L-proteins), which catalyzes the oxidative cleavage of glycine. The H-protein shuttles the methylamine group of glycine from the P-protein (glycine dehydrogenase) to the T-protein (aminomethyltransferase) via a lipoyl group, attached to a completely conserved lysine residue.
Links
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Statistics
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PSSM-Id: 527916
Aligned: 196 rows
Threshold Bit Score: 99.4492
Created: 30-Sep-2008
Updated: 17-Dec-2025
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site include 1 residue -Click on image for an interactive view with Cn3D
Feature 1: lipoyl attachment site [posttranslational modification site], 1 residue position
Conserved feature residue pattern:KClick to see conserved feature residue pattern help
Evidence:
  • Structure:1HPC; Pea lipoamide-containing H-protein of the glycine decarboxylase complex (at lysine 63)
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                        
1HPC_A         7 LKYAPsHEWVKHEgs-----------vATIGITDHAQDHLG-EVVFVELPEp---GVSVTkGKGFGAVESV--------- 62  pea
XP_635521     27 THYSAeLEWVKLSddn---------kvATVGLSSFGAQRLG-KINYVELPKe---HRKCRrEEKFGVLESSn-------- 85  Dictyostelium d...
XP_001299513  14 KLYAKtHEYIDVEgt-----------iGKIGLSEFAMKMLG-KATFVDVQV----GKTFKkSEEFGTVEAT--------- 68  Trichomonas vag...
XP_001317955  11 KQYSKdHLWFDLAnk-----------vGKFGVTSYKGYHLG-NIKFLALAP----EGTYKkGEELATIESD--------- 65  Trichomonas vag...
XP_001348010  28 TYYTKtHEYIKIEdgnlnnrkdmtnvkCKIGISNYGTHKLG-EIVYVDVAHn--iNDHVKkGDCIATIESV--------- 95  Plasmodium falc...
WP_164922010  27 YRYAKnHMWATPSpdqsaat-gdahcvWRFGLSAYAVRLLQ-DVYFLDWIVe--aGTPLTaRKTIGSIESK--------- 93  Rhodopirellula ...
Q9PKB2         5 KYYSDyHVWIEPIhs----------qiVRLGLSSRMQEHLG-NILHIDLPSl---GASIKeGEELCVLESS--------- 61  Chlamydia murid...
TET25133      35 RDYTKtHMWIKNTle----------gnQKIGVTDYAQQHLReKVGLVEIFKnptvGEEFEvEEVFGTIYGRpcanldemr 104 Candidatus Bath...
RKU38051       6 IRYTItHEWAEILds----------meCSIGITERAQEIYS-NIIFIELPS----LGEFEqDEIIGHLETSd-------- 62  Candidatus Pori...
OHD57546       2 RLYGEsHSWVKMDgk-----------tAVIGISKYYAGMMG-KIRYVEYPDv---GGKAEcGAKLCTIIAQi-------- 58  Spirochaetes ba...

Feature 1          #                                           
1HPC_A        63 --KATSDVNSPiSGEVIEVNTGLTGKPGLINsspyeDGWMIKIKPT 106 pea
XP_635521     86 --ATAFGLYAPvSGEVLEVNEKLKKSPSLLNed-paNNWMVKFKVS 128 Dictyostelium discoideum AX4
XP_001299513  69 --KAVTPVQTPvSGKIIEANAAVLDNPELLSkkpetDGWFAKISLS 112 Trichomonas vaginalis G3
XP_001317955  66 --KTIESIAAPvDLKITQTNTKLEDNPKLLKtsaekNAWIAQIEIL 109 Trichomonas vaginalis G3
XP_001348010  96 --KSVGDVYTPvSGKIININNKIIDNVNLMNeqseiDGWIMELETN 139 Plasmodium falciparum 3D7
WP_164922010  94 --KAESDLFSPiAGELIVINADALDEPSVINaspyvDGWLIEIRGN 137 Rhodopirellula baltica
Q9PKB2        62 --KSAIEVLSPvSGEVIEVNIALEDDTHPINhsaesEGWFVVLQLS 105 Chlamydia muridarum str. Nigg
TET25133     105 ceYVAFDLIAPiSGKIVEINRRIMETPEVINtspyeEGWIVIIAPK 150 Candidatus Bathyarchaeum sp.
RKU38051      63 --GRNFYIHAPvSGEVYEVNTTLEDDIELLNrfpegDGWICKLRIE 106 Candidatus Poribacteria bacterium
OHD57546      59 --VPQAKILAPvSGKIVEVNRRLVTFPEILNedplgEGWLVKVVPP 102 Spirochaetes bacterium GWF1_51_8

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