Conserved Protein Domain Family
PLPDE_III_MccE_like

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cd06841: PLPDE_III_MccE_like 
Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme MccE
This subfamily is composed of uncharacterized proteins with similarity to Escherichia coli MccE, a hypothetical protein that is homologous to eukaryotic ornithine decarboxylase (ODC) and diaminopimelate decarboxylase (DapDC). ODC and DapDC are fold type III PLP-dependent enzymes that contain an N-terminal PLP-binding TIM-barrel domain and a C-terminal beta-sandwich domain, similar to bacterial alanine racemases. ODC participates in the formation of putrescine by catalyzing the decarboxylation of ornithine, the first step in polyamine biosynthesis. DapDC participates in the last step of lysine biosynthesis, the conversion of meso-2,6-diaminoheptanedioate to L-lysine. Most members of this subfamily share the same domain architecture as ODC and DapDC. A few members, including Escherichia coli MccE, contain an additional acetyltransferase domain at the C-terminus.
Statistics
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PSSM-Id: 143508
View PSSM: cd06841
Aligned: 19 rows
Threshold Bit Score: 419.36
Threshold Setting Gi: 120586900
Created: 19-Jun-2008
Updated: 2-Oct-2020
Structure
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Aligned Rows:
Conserved Features/SitesClick to see Conserved Features Help
 
Feature 1:active site [active site]
Evidence:
  • Comment:Based on the structures of PLP and substrate bound to ornithine and diaminopimelate decarboxylases.
  • Comment:The active site is composed of residues from both subunits of the dimer. There are two active sites in the functional dimer.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                  # #                  #                
YP_001649251  21 GIESGDNSFVIFDVDgalERLEHYRCQLKSF---FPNSSIAYSYKSNNLAQWCQIISGKGLYAEVCSVDEMNLAKRDGF- 96  Escherichia coli
YP_001322929  11 LNEDFGDSFYLLDSN---KFVKNYDEFLGEFqkiYPNTVIAYSYKTNYLPHLCSIVNKKGGFAEVVSKMEYDLAIKIGVi 87  Methanococcus v...
YP_001305143   8 LIKSNGTPFYLFDEK---GFIDNYRKLEGIFkaiYPNYQLSYSYKTNYTPFVCQLVRSLGGYAEVVSDMEYTLAKKLGYd 84  Parabacteroides...
ZP_02066679   15 LRKEYGDAFYLLDSG---QFRNNFIELKDTFrkiYPNFNIAYSYKTNYTPKFCKIVNELGGYAEVVSEMELEIALRVGVe 91  Bacteroides ova...
YP_001301266   2 QLSNLKTPCFILDSD---KLVSNVLEFKRALnsrFSNHCIGYSIKTNSLPYMLHMLNELGCYAEVVSYTEYALALQVGFe 78  Bacteroides vul...
ZP_01235115    9 LSEVYGDSYYLLDSK---KFEDNFECLLDAFnsiYSNTKIGYSYKTNYIPKLCKIIDIKGGYAEVVSDMEYDLAIKLGVe 85  Vibrio angustum...
ZP_02834845   20 RPSHSDRPFFIFDAD---SALERARHLTAACkeyFPDAVIAVSVKSCSLGIFLRLIAEEGLSAEVCSADEFKLALKAGFt 96  Salmonella ente...
YP_382791     13 IRDSETGPFYLIDFD---GIENSIMRLKSAFdadFKKVRLAYSFKTNSLQAITTFMHSKSMGAEVVSGQELEWALSDNFe 89  Synechococcus s...
YP_989054     20 RPGHTDFPFFLFDAD---NALAKAKTLISASkkyFTDSNIAVAIKSCSLGIFCKLLAEEGLNAKVCSADEFQIALFAGFp 96  Bartonella baci...
YP_630578     59 LVERWGSPLHVVHMA---ALRRNAERFLAVPpgrTGGCEVYYSYKTNPVPGVLSFLHGLGVGAEVISAYEMWLALKLGVp 135 Myxococcus xant...
Feature 1              #                                               #                         
YP_001649251  97 -NRIVFDGPLKKtSELLKAIEIG-ALIEVDNiDECKRLNELCKLh-kLTCRIHLRLSHYYDdn----------lSRFGLS 163 Escherichia coli
YP_001322929  88 pSNIIVNGPLKTkEHLEYFLLKG-SIVNVDSyRELDLIREIANSnpgKILSVGIRCNFEMGst----------vSRFGFD 156 Methanococcus v...
YP_001305143  85 nKQIVYNGPSKG-EEMFDHLEHQ-GILNIDSlDEAKRIISYVKGhpdRNYTVGIRINMHVGgd---------fiSRFGLV 153 Parabacteroides...
ZP_02066679   92 sKRIIWNGPIKNaKKLEEFLVAG-GTDNIDSvEELAVVKAIAERhpdKVLNLGIRCNYDVQdg---------vvSRFGLD 161 Bacteroides ova...
YP_001301266  79 kSHIVYNGPAKDkETFLDAIKNG-AYVNIDTkREIEWLNDLNKQ---HSYKVGIRVNLNLGkispedakegesdSRFGFS 154 Bacteroides vul...
ZP_01235115   86 pERIIVNGPYKPkNILEKFLLNK-SIVNLDSfVEIEYLKEIALKnptNMIEFGIRCNFDIHnn---------vvSRFGID 155 Vibrio angustum...
ZP_02834845   97 gDRIILDGPYKNsEDLSLALDKG-ALVHIDSaHELSEIIGLMSGy-nQKIGVGVRLSHIYSdt---------qrSRFGVT 165 Salmonella ente...
YP_382791     90 pNNIYFDGPVKSkKEHKRAAELN-VNIQVDSvQELIDLLEITSDp--SKLKVGARLSMPYKnk---------inSRFGLT 157 Synechococcus s...
YP_989054     97 nDRIILGGPLKTsEDLSFALEKD-ALIYVDSvSELRKLNTLAVNk-nRRYGVGIRLSHFYRng---------kySRFGIT 165 Bartonella baci...
YP_630578    136 pERIVYNGPVKSeASVREAISRGiQLLAANHaEEIAVFARLAAEl-dRRPRVAVRVTTNSGw-----------sAQFGTP 203 Myxococcus xant...
Feature 1                                     #  #                                     ##        
YP_001649251 164 es-eAINLLEMLISKs---eYLILDGFHLHVGSNl---pNAEKICKAVIQYHELIlry--mpDDGTLNLGSGIPADSfsa 234 Escherichia coli
YP_001322929 157 vrdaEFIEKFKELKKi---dNLYIKGIHCHFPDR-----NLDSYSKRVDNLINILdllfkenIPEFVDIGGGYFGKVndf 228 Methanococcus v...
YP_001305143 154 p---ESKELQETVSLiketvNLNLIGLHCHISRSr----GVEAWTKRTEIMLKAAddy-idgVPAYISLGSGMYADMpef 225 Parabacteroides...
ZP_02066679  162 vdseDFQQVLEFVITt---kNVHFINFQCHFAKR-----QIEYWSARAKGMVELIdri--giIPERLDVGGGLFGKMads 231 Bacteroides ova...
YP_001301266 155 f---ENGELEEAINKiqlckNVKLGGLHLHRTSLt---rSLNVYRNICKYAIRIInsl--glELDYIDVGGGYFGDKpn- 225 Bacteroides vul...
ZP_01235115  156 i---NNPDLLKKLKEiseikNVKFVGIHCHYPDR-----NADSYSVRAKKIIEVAssl-fttPPKYIDIGGGFFGKMder 226 Vibrio angustum...
ZP_02834845  166 a--eEFRDEIVPLLTsc--pDISLRGFHLHTGSNl---eNPSKVSDCLRDWLPFLven--mpEGGHLDMGSGFPADSfsp 236 Salmonella ente...
YP_382791    158 r--sEFKEATTIMKRt----GISFSGLHLHSGSNi---tNINQYRESIMSCIDCItet--whELSWIDFGGGFPANTala 226 Synechococcus s...
YP_989054    166 ke-eYINDILPILSNt---dHLYLQGFHLYVGSNp---eNYPKITDTLHHWLPFLveh--mpSSGHLDISTDFLTNPep- 235 Bartonella baci...
YP_630578    204 i---AGGAALRAYQQargskHLDVVGLHAHRGETirtegDFTAFVESVLDFTDTLhqe-lglDLEVLDLGGSLNTPTveh 279 Myxococcus xant...
Feature 1                                                               ####                     
YP_001649251 235 ss------------------dnptPCPEVFFSSIYDTIkncfg--tvcdKWNYIFEPGRHLVEDFGYFIGKVISTKNRyG 294 Escherichia coli
YP_001322929 229 lak---------------qfncnvPSYSDYASIIASRFkeyfknipenrKPKLILEPGTALVADTMKFIAKIVEIKNIrG 293 Methanococcus v...
YP_001305143 226 lkqq--------------fggdtvPTYEDYADCTIQPFadhyk--dvenQPILFTEPGTTVVARYLSFVTKVLSVKEVrG 289 Parabacteroides...
ZP_02066679  232 lka---------------qfkndiPDYQAYAEATATIFadyfa--dknvKPELLIEPGSAVVGDCMKFVGTVKTIKCVrG 294 Bacteroides ova...
YP_001301266 226 -----------------------aPTYKEYVDTIYSSLleeg---idvsKMKVIVEPGNAIVASPFSFLSEIIDTKKIgD 279 Bacteroides vul...
ZP_01235115  227 lkk----------------qfssyHDYKEYANNIATEFkraysalpkeeQPILFLEPGSALVADTMKFVCRVIDIKNIrG 290 Vibrio angustum...
ZP_02834845  237 va------------------avptVEPAAFFRDIVSVLseydp--aliqKWKLIFEPGRTLSEDHGYAIGKTVSVKNRyD 296 Salmonella ente...
YP_382791    227 ne------------------seelPTPEAFSSCIKSIIskkn---lslnNKTVVIEPGRCLVEDNGLLLARVEQIKKReD 285 Synechococcus s...
YP_989054    236 ----------------------enYDPETIFRSIHDVLnsydp--nlskRWKLIFELDHYLNKDSSYVIGKALGYKNHyD 291 Bartonella baci...
YP_630578    280 iaerdwrlnltffrdvpapdpaasLSIDRYVALAVEMVethya-rrgrqRPRIFLEPGRAMTGDTQLLLGRVHALKAGeD 358 Myxococcus xant...
Feature 1                                                       ##                             # 
YP_001649251 295 VKVAQTNIGINWIPSi-RNWDHSFTLFhnhnhisddksdEYIIAGFNCFEcDCLFPSVILPs--NLSDYLFSVRGCGAYD 371 Escherichia coli
YP_001322929 294 KKIAMTTGSKFNMGLfgLSINLPINVYsefkn--gkfinNVDISGYTCIEaDYLFKNYCGI---LNIGDYIAFDNVGSYS 368 Methanococcus v...
YP_001305143 290 RYIANMDGDYHNLGEicTMKKLPVTVLsggke--qhtytNMDIMGFTCLEqDVLYPGFEQS---IAEGDILVFDNVGGYS 364 Parabacteroides...
ZP_02066679  295 KWMATVLGSQKNISM--SGINPPMEVItmgge--qkeykDLDFVGFTCIEgDVLYNNYNGK---LAHEDAIVISNCGSYS 367 Bacteroides ova...
YP_001301266 280 SQIIVTDGSRNDVDPf-FLKKDYFKSFirkqee-kvfidSQMVVGCSCLEyDKLFTLQNQPl--LNVGDRILYQNVGAYT 355 Bacteroides vul...
ZP_01235115  291 TNIAMTSGSKFNIGLlsSTVNMPLDVHskyin---dkvnEYDISGFTCIEsDYLFKGYTGC---LFQGDFLIFNNVGSYS 364 Vibrio angustum...
ZP_02834845  297 SEVIQTNLGINWIPSv-HNWHHSLLPLghneh--ipddtTQILAGFNCFEnDCLFPRGPLN---LKKNQLFIIRGCGAYD 370 Salmonella ente...
YP_382791    286 RNIVVTNAGLNLVKSm-HSWYHPVIFLrqeid--eeqstPYEVYGCNCFEsDLIIDELEGPpsdLRIGDWIAIGSTGGYD 362 Synechococcus s...
YP_989054    292 AKIIQTNLSINWITSi-HNWHHSLTLLndgdk--dstqdKQILAGFNCFEdDSLSPQGYYG---LTEGQHFLIRSCSNYN 365 Bartonella baci...
YP_630578    359 RTWAVLDAGINHAECvrNEYHQLFHVNrpda----padkVYTVVGPICTPgDTLYHAKRLPd--LRVGDTLAIMDAGAYF 432 Myxococcus xant...
Feature 1          #   #              
YP_001649251 372 MQTGnQWTRNLYAVYTITNDV 392 Escherichia coli
YP_001322929 369 FVFKpPFICPNVPIIDYNGDK 389 Methanococcus vannielii SB
YP_001305143 365 IVSKpQFIKPQSAMYVLRTNG 385 Parabacteroides distasonis ATCC 8503
ZP_02066679  368 LVMKpPFILPNFPVLDICGEK 388 Bacteroides ovatus ATCC 8483
YP_001301266 356 MTLSpLFIRFFPRVYLKTLNG 376 Bacteroides vulgatus ATCC 8482
ZP_01235115  365 IVFKpPFILPNVPIIELTGNS 385 Vibrio angustum S14
ZP_02834845  371 LQTAnEWTRTRPPVYALLNQE 391 Salmonella enterica subsp. enterica serovar Weltevreden str. HI_N05-537
YP_382791    363 MQNFnAWTQPYPSIYGSSREG 383 Synechococcus sp. CC9605
YP_989054    366 MQASnEWTRKKPPVYIWLRGS 386 Bartonella bacilliformis KC583
YP_630578    433 VPFAtSFSYPQPAIVALEDGK 453 Myxococcus xanthus DK 1622

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