Conserved Protein Domain Family
PLPDE_III_CANSDC

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cd06829: PLPDE_III_CANSDC 
Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase
Carboxynorspermidine decarboxylase (CANSDC) catalyzes the decarboxylation of carboxynorspermidine, the last step in the biosynthesis of norspermidine. It is homologous to eukaryotic ornithine decarboxylase (ODC) and diaminopimelate decarboxylase (DapDC), which are fold type III PLP-dependent enzymes that contain an N-terminal PLP-binding TIM-barrel domain and a C-terminal beta-sandwich domain, similar to bacterial alanine racemases. Based on this similarity, CANSDC may require homodimer formation and the presence of the PLP cofactor for its catalytic activity.
Statistics
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PSSM-Id: 143502
View PSSM: cd06829
Aligned: 42 rows
Threshold Bit Score: 441.99
Threshold Setting Gi: 53803251
Created: 15-Feb-2008
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
Feature 1:active site [active site]
Evidence:
  • Comment:Based on the structures of PLP and substrate bound to ornithine and diaminopimelate decarboxylases.
  • Comment:The active site is composed of residues from both subunits of the dimer. There are two active sites in the functional dimer.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                        # #                  #                       #   
YP_001356762   16 TPCYVCEEGLLRRNLEILDEVQQKSGAKIILALKGFAMWSTFDILKQYLHGATASGLWEAKLAFEELGk--EVHTYSPAF 93   Nitratiruptor...
YP_865006      42 TPCHILDGATLTKNGEILADVAARSGATLLLALKAFAQPECFKFLKGHLHGVAASSLHEARLGQEHFGg--ELHTYAPAY 119  Magnetococcus...
NP_438090       4 TPYYLIDKAKLTRNMERIAHVREKSGAKALLALKCFATWSVFDLMRDYMDGTTSSSLFEVRLGRERFGk--ETHAYSVAY 81   Sinorhizobium...
NP_879554       4 TPYYLIDKRALLQNLEVIRRIRERSGAKVLLALKCFATWSVFDLMREYMDGTTSSSLFEVRLGREKFGg--ETHAYSVAY 81   Bordetella pe...
NP_745073       4 TPYYLIDKTKLLSNMEKIAYVREHSGAKALLALKCFATWSVFDLMQQYMDGTTSSSLFELKLGRQKFAg--ETHAYSVAW 81   Pseudomonas p...
YP_001280606    4 TPYYQIDIAALKQNLQIVQRLCDLSGAKALLALKCFATWGVFDEMTPYLHGTTSSSLNEVRLGKEEFGedkETHAYSVAY 83   Psychrobacter...
ZP_02925472     5 TPYYLIDEARMLPAMERIRLVQERSGAKCVLALKCFSSWCAFDFMRQYLVGTTSSSLWETRLGHEKFGg--ETHGYSVAY 82   Verrucomicrob...
NP_231262      18 TPYFMIDEAKLIANLEIAKHLKEISGVKMVLALKCFSTWGVFDIIKPYLDGTTSSGPFEVKLGYETFGg--ETHAYSVGY 95   Vibrio choler...
BAG13933        7 TPYYLIDERKLLRNLKKIKYVRDNSGAKSVLALKCFSTWAVFDLMSKYMDGTTSSSFYEAKLGHEKFGk--ETHAFSVAY 84   uncultured Te...
EDO90124      738 TPAFVYDERTLRDALSSMHTLLGDSGCRLLYPLKPFSHAGALECIGPHVDGFAASSPFEAAFSRMLLGragSVHLATPAL 817  Burkholderia ...
Feature 1                                                  #                                      
YP_001356762   94 KEDEIELIAKMSDHIVFNSMHQFNAFKDIVKktdpDISIGVRVNPEYSAAPv--DLYNPCGAFSRLGVVr--------SE 163  Nitratiruptor...
YP_865006     120 LPDEMDYIAQHATHIVFNSFNQWRRYKGQLQg--sQASVGMRINPERSTRGgdfDSCDPCQPGSRMGVPla------lFE 191  Magnetococcus...
NP_438090      82 GDNEIDEVVSHADKIIFNSISQLERFADKAA----GIARGLRLNPQVSSSSf--DLADPARPFSRLGEWdv------pKV 149  Sinorhizobium...
NP_879554      82 AEDDIDDVVACADKIIFNSLSQLERYAPRAS----AIPRGLRLNPGISVSGy--DLANPARPFSRLGETdl------dRI 149  Bordetella pe...
NP_745073      82 ADDEVEEMLENCDKIIFNSIGQLQRFAEQSE----GKVRGLRVNPQVSSSDy--LLADPARPFSRLGEWdp------aKI 149  Pseudomonas p...
YP_001280606   84 SADEIDEVLTYADKIIFNSFNQLHAFKDKAKa--qGIPVGLRINPKTSNSSf--IIADPARPFSRLGEHdi------qKI 153  Psychrobacter...
ZP_02925472    83 ADDEIAEVAGYCDKIIFNSLGQLNRLGHHAA----GISMGLRLNPGIGHSCs--ELSNPVCQYSRLGVRae------eLP 150  Verrucomicrob...
NP_231262      96 SEEDVKEVIDICDKMIFNSQSQLAAYRHLVEg---KASLGLRINPGVSYAGq--DLANPARQFSRLGVQad------hID 164  Vibrio choler...
BAG13933       85 SSDDVKALKNIADKIIFNSVSQLNMFYNDIK----HIKVGLRINPGISYSHf--DLADPSRKYSRLGVTle------eEI 152  uncultured Te...
EDO90124      818 RDRDLGTIVDNCDYVALNSLSQWRRLHDALAg---RLSCGLRINPQYSVVAd--ARYDPCRPHSKLGVPldaiervvaSD 892  Burkholderia ...
Feature 1                     #  #                                ##                              
YP_001356762  164 FSWDDAIKGLHFHALCEE-SAESLEGVLKAFEERFGEFVPKCKWINFGGGHHITkegYNRELLIKLIRDFKKRYDVEVYL 242  Nitratiruptor...
YP_865006     192 ADAMEGIEGLHFHTLCMQ-GPAALARTLEAVEARFGHVFHKLKWINFGGGHLIThpnYDRERLIQLIKDFRAKHGLAVTL 270  Magnetococcus...
NP_438090     150 ERVMDRINGFMIHNNCENkDFGLFDRMLGEIEERFGALIARVDWVSLGGGIHFTgddYPVDAFSARLRAFSDRYGVQIYL 229  Sinorhizobium...
NP_879554     150 AQAMPMIDGFMVHNNCENrDFTRFDALLTELEHRYGHLLGQINWISLGGGIHFTepgYALDAFCDRLRRFSEQYGVQVYL 229  Bordetella pe...
NP_745073     150 EQVIEQISGFMFHNNCENgDFGLFDKMLTHIEERFGHLLHKVEWVSLGGGIHFTgedYAVDAFCARLKAFSEKYGVQVYL 229  Pseudomonas p...
YP_001280606  154 KPVIDDITGVMIHNNCENnSFEAFSDSLADIEAKFGELFYQLEWVSLGGGIHFIapdYPLEKLAQRLKSFSEKYGVQVYL 233  Psychrobacter...
ZP_02925472   151 EDIGSRIQGAMIHVNCDNdDLASFCSQLDVIEERFGKLLPHLQWLSFGGGIAFTdeaYPIDDFCRRLREFSQRHSLEIYL 230  Verrucomicrob...
NP_231262     165 ESVFDSINGVMFHMNCENkDVDAFIGLLDAISERFGRYLDKLDWVSLGGGVFFTwpgYDVEKLGAALKAFAERHAVQLYL 244  Vibrio choler...
BAG13933      153 MSVLDKISGLMFHYNCENdDFKSFSVMLDEIAAKYEKVLNKVEWVSLGGGLYFTkdgYPLDKFCKKLKSFSKKHNVLVYL 232  uncultured Te...
EDO90124      893 PRALHGLQGIHFHTNCDStDFSRLAETIEHLEKRLARTLDGLAWINLGGGYIADg-aRYVDRFRACAKRLREHFGVALFI 971  Burkholderia ...
Feature 1         ####                                                                          ##
YP_001356762  243 EPGEAVGWQTGVLVATVVDIVHN-GMDIAILDTSAETHMPDVlaMPYRPDVRGAak--------pGEKPYTYRLGGNSCL 313  Nitratiruptor...
YP_865006     271 EPGAGVVFNTDVVVAQVQDIIHT-ATPNVILDLSAAAHVTDVldLGWRPTIWGAgr--------eGEYAHTYRLGGHSCL 341  Magnetococcus...
NP_438090     230 EPGEASITKSTTLEVTVLDTLYN-GKNLAIVDSSIEAHMLDL--LIYRETAKVLp----------NEGSHSYMICGKSCL 296  Sinorhizobium...
NP_879554     230 EPGEAAITNTATLEVTVLDVMRN-EKNLAIVDAATEAHMLDL--LIYRMSARVQp----------DQGPHRYVIYGNSCL 296  Bordetella pe...
NP_745073     230 EPGEAAITNSASLEVTVLDTLYN-GKHLAVVDSSIEAHLLDL--LIYRLNAKMAp----------NDGEHTYMVCGKSCL 296  Pseudomonas p...
YP_001280606  234 EPGEACIHNAAKLVTTVLDTLHN-GKPLAVVDASIEAHMLDL--LIYRETAPLVqindeacqitsQQSDDSTIIYGKSCL 310  Psychrobacter...
ZP_02925472   231 EPGEAAVTHSTSLVVKVLDVVEN-EVPTLVVDAGVETHLLDVltYGYTPEVDGAeplardakdlgGRAGHVYRICGRTCL 309  Verrucomicrob...
NP_231262     245 EPGEAIITKTTDLVVTVVDIVEN-GMKTAIVDSATEAHRLDT--LIYKEPASVLea--------sDKGQHEYVIGSCSCL 313  Vibrio choler...
BAG13933      233 EPGETAIIKSCELITTILDIVKN-VKDIAIVDASIEAHMLDL--LIYRTPAEINa----------KDGKNEYIIAGRSCL 299  uncultured Te...
EDO90124      972 EPGAAIVRAAGTIIASVVDLFDSgGMPIAVLDTTVNHYPEVFe-YQFQPDVDGHh----------PAHAHAYLLAGASCL 1040 Burkholderia ...
Feature 1                                    #   #   #            
YP_001356762  314 AGDIIGDYSFDEPLQrGQKLVFEDMIHYTFVKNTTFNGIRLPSLALLK 361  Nitratiruptor sp. SB155-2
YP_865006     342 SGDYFGLYSFPEPLQiGQKLVFLDMAHYTLVKMTTFNGLALPTLHIRD 389  Magnetococcus sp. MC-1
NP_438090     297 AGDVFGEFRFAEELKvGDRISFQDAAGYTMVKKNWFNGVKMPAIAIRE 344  Sinorhizobium meliloti 1021
NP_879554     297 AGDVFGEFSFESPLQpGSRISIQDAAGYTMVKKNWFNGVRMPAIAIRE 344  Bordetella pertussis Tohama I
NP_745073     297 AGDIFGEYQFDRPLAiGDRLSFIDTAGYTMVKKNWFNGLKMPSIVVKQ 344  Pseudomonas putida KT2440
YP_001280606  311 AGDIFGEYALDKPLTiGDKVSFGNAAGYTMVKKNWFNGVAMPAIVICD 358  Psychrobacter sp. PRwf-1
ZP_02925472   310 AGDHFGNYVFPRPVAlGDELRFPNVGGYSMVKKNYFNGIRMPAIYHRN 357  Verrucomicrobium spinosum DSM 4136
NP_231262     314 AGDQFCVAKFDEPLQvGQKLHILDSAGYTMVKLNWFNGLKMPSVYCER 361  Vibrio cholerae O1 biovar eltor str. N16961
BAG13933      300 AGDIFGEYKLADKLKvGSTVHFANAAGYTMVKKNWFNGLKMPSIVVKK 347  uncultured Termite group 1 bacterium phylotyp...
EDO90124     1041 AGDVFGTYRFDAPLRvGSRVAFVNAGAYTLVKAHRFNGINLPSVYRRG 1088 Burkholderia pseudomallei Pasteur 52237

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