1W8G


Conserved Protein Domain Family
PLPDE_III_Yggs_like

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cd06824: PLPDE_III_Yggs_like 
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Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins
This subfamily contains mainly uncharacterized proteobacterial proteins with similarity to the hypothetical Escherichia coli protein YggS, a homolog of yeast YBL036c, which is homologous to a Pseudomonas aeruginosa gene that is co-transcribed with a known proline biosynthetic gene. Like yeast YBL036c, Yggs is a single domain monomeric protein with a typical TIM-barrel fold. Its structure, which shows a covalently-bound PLP cofactor, is similar to the N-terminal domain of the fold type III PLP-dependent enzymes, bacterial alanine racemase and eukaryotic ornithine decarboxylase, which are two-domain dimeric proteins. YggS has not been characterized extensively and its biological function is still unkonwn.
Statistics
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PSSM-Id: 143497
View PSSM: cd06824
Aligned: 35 rows
Threshold Bit Score: 315.284
Threshold Setting Gi: 32490829
Created: 21-Mar-2008
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
pyridoxalcatalytic
Conserved site includes 9 residues -Click on image for an interactive view with Cn3D
Feature 1:pyridoxal 5'-phosphate (PLP) binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                      # #                    #                         
1W8G_A        3 DIAHNLAQVRDKISAAAtrcgrspeEITLLAVSKTKPASAIAEAIdAGQRQFGENYVQEGVDKIRHFQElgv-----tgL 77  Escherichia coli
Q89A48        3 NIQKNIKKLKQKITNISkkfkintqKIKLLAVSKNRSVNDIKKAIlCGQNSFGENYVQESQPKIKLFNN----------I 72  Buchnera aphidic...
Q8K929        3 NININIKIIKKKIQYFLkknnyplkKIKIIAVSKNQGIDKIKLAIsSGIHEFGENYVQEGIDKIQKLKKyq-------nI 75  Buchnera aphidic...
NP_871083     4 LIKKNLEKIQNKIYNLSkyynrnpkNINLLLASKSRSVYEIKFANeYNQNNFGENYVQEAIKKIVWFKKnhp----knnL 79  Wigglesworthia g...
YP_096030     2 SISQNINKVRELITQTEsssnrqpnSVLLLAVSKEQSPELIREAFqQGIRHFGENYFQEAQEKILALRDl--------pI 73  Legionella pneum...
ZP_01916369   2 SRATQLADIQSRIENACskagrpgsAVKLLAVSKTFPLSDILEFYnCGQTAFGENYLQEALDKITQLADhpnaqtintnL 81  Limnobacter sp. ...
AAQ95748      3 QIAEHLLQVKERIVQAAsragrrgdHIQLLAVSKTKPLEAVCEAYaAGQRRFGESYAQEAATKIDTLREqgt----ctdI 78  Aeromonas hydrop...
ZP_01898121   3 SISTRLQQVLTQIENATsasckkrsEINLLAVSKTKPVEQVMAVYaLGQRKFGENYLQEAVEKITHLQQdgn----yddI 78  Moritella sp. PE36
ZP_01552513   3 KIKKNLLILNQQIESIKas-----nRTVIVAVSKKQDSSKIIEAIkSGQTIFGENYVQEALEKQEILKKy--------nL 69  Methylophilales ...
YP_944341     3 NISKKIKNVEQTIIQAAqragrnadQIQLLAVSKTKPVALIKEAYlAGLRHFGENYVQESIEKIQQIKLdtdf---eqaV 79  Psychromonas ing...
Feature 1           #                                                                           
1W8G_A       78 EWHFIGPLQSNKSRLVAEHFDWCHTIDRLRIATRLNDQRPaELPPLNVLIQINISDEnSKSGIQLAELDELAAAVAE-LP 156 Escherichia coli
Q89A48       73 EWHYIGQIQSNKAHIIAKNFSWCHTITNKKTAVLLNKYRPySLPKLNTLIQINIRDNtINIDDDIETIKQLAKTINS-LD 151 Buchnera aphidic...
Q8K929       76 IWHFIGKVQSNKTKIIAENFDWCQTIDREKIAILLNKYREkKSFPMNVLMQINISNEvTKNGICIKNYKKLAKTISL-MP 154 Buchnera aphidic...
NP_871083    80 IWHMIGQIQSNKSKLIAKYFDWCHTINNIKISKKLNNYRKiKKKPLKVLIQININEEkNRYGSSLKEFDNIYEFIFQkCN 159 Wigglesworthia g...
YP_096030    74 CWHFIGPIQSNKTKGIAKYFNWVHSIDRNKTAKLLNQFRSeQLPPLNVCLQINLTGEtTKSGIPPEHAIDLALEVKQ-LP 152 Legionella pneum...
ZP_01916369  82 EWHFIGPIQSNKTKPIAENFSWVHSVDRLKIAQRLSDQRPdKLGPLNVLVQINTSGEdSKSGVNAEQTADLCLQIQS-LK 160 Limnobacter sp. ...
AAQ95748     79 EWHFIGPLQSNKSKLVAERFDWVQSVDREKLIERLNNQRPaGLAPLNVCLQINISGEsSKSGTSEQEIFRLAELVSR-CE 157 Aeromonas hydrop...
ZP_01898121  79 EWHFIGPIQSNKTRPIAEHFDWVQSIDRLKVAQRLNDQRPaDMPKLNVCIQINISAEdSKSGADVQQAHLLAEQVAN-LP 157 Moritella sp. PE36
ZP_01552513  70 EWHFIGPIQSNKCKAIAENFSWVQTVDRLKTAIRINDARE-GMEPINVCLQINISSEdSKGGVMLEAAEDLFKEVSK-LK 147 Methylophilales ...
YP_944341    80 FWYFIGPLQSNKTRPVAENFDWVQSVERLKIAQRLNDQRPdHLPKLNVCLQVNISGEqSKSGTTLLQVIELASQVNN-LP 158 Psychromonas ing...
Feature 1                #                                      #               # ##     
1W8G_A      157 RLRLRGLMAIPAPeseyvrQFEVARQMAVAFAGLKTry-phIDTLSLGMSDDMEAAIAAGSTMVRIGTAIFGA 228 Escherichia coli
Q89A48      152 NLNLRGIMAMPYFkntyleQIQSYKYIHLYFDILKKky-tyIDTVSLGTSHDIQAALYSGSTLLRIGSSIFDV 223 Buchnera aphidicola (Ba...
Q8K929      155 NLNFRGIMMMPEVekkmikQNDNYKNGNFIFNELKKey-qsIDTLSLGTSFDIENALLFHSNMIRIGRFIFKN 226 Buchnera aphidicola (Sc...
NP_871083   160 NLMLKGIMIFPIItddlnkKIYNFNIIIDKFNTLKNkn-snFNVLSFGTTSDIDHAIKIGSTLLRIGKGIFEN 231 Wigglesworthia glossini...
YP_096030   153 NLQLRGLMTIPPQqnnmqtQYNLFLKLNQLKESINKalhlkMDTLSMGMSDDLVPAIKAGSTIVRIGRAIFGE 225 Legionella pneumophila ...
ZP_01916369 161 NIALRGLMTIPSNtdnvdqLKAEFLKCKLIFDSLNSkg-lrMDTLSMGMSADLELAIECGSSCVRVGSALFGA 232 Limnobacter sp. MED105
AAQ95748    158 RLRLRGLMAIPEHtsdeavLAAQMVRMQTLFTELARqy-pgVDTLSMGMTEDLELAIGHGSTMVRVGTAIFGA 229 Aeromonas hydrophila
ZP_01898121 158 NLVLRGIMAIPEKtadidkLKSQFSQLESLYLSLQHqy-nqIDTLSMGMTNDMELAIAQGSNMVRVGTAIFGA 229 Moritella sp. PE36
ZP_01552513 148 NLNIRGLMAIPSNtsnahvLKKEFQLLKNAYDEFKKty-psIDTLSMGMSNDYLEAIQQGANMIRVGSNIFGE 219 Methylophilales bacteri...
YP_944341   159 RLTLRGIMAIPEKtddqlrLEKQFNELHNIYLHLQQly-pqVDTLSMGMSGDLEKAIACGSTMVRIGTDIFGS 230 Psychromonas ingrahamii 37

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