1DCZ,1PMR,1ZKO,2EJM,1BDO,2PNR,1HPC


Conserved Protein Domain Family
Biotinyl_lipoyl_domains

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cd06663: Biotinyl_lipoyl_domains 
Click on image for an interactive view with Cn3D
Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl, or methylamine, respectively, between components of the complex/protein via a biotinyl or lipoyl group, which is covalently attached to a highly conserved lysine residue.
Statistics
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PSSM-Id: 133456
View PSSM: cd06663
Aligned: 7 rows
Threshold Bit Score: 69.7779
Threshold Setting Gi: 159162200
Created: 8-Jan-2008
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
lipoyl-biotinyl
Conserved site include 1 residue -Click on image for an interactive view with Cn3D
Feature 1:lipoyl-biotinyl attachment site [posttranslational modification site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                    #                                
1DCZ_A     10 EIPAPl-------AGTVs-------kILVKeGDTVKAGQTVLVLEAmKMETEINAPTDGKVekVLVKerda-------vq 68  Propionibacterium ...
1PMR_A      4 DILVPdlpe-svaDATVa-------tWHKKpGDAVVRDEVLVEIETdKVVLEVPASADGILdaVLEDegtt-------vt 68  Escherichia coli
1ZKO_A     33 TVGITnhaqeqlgDVVYv--------DLPEvGREVKKGEVVASIESvKAAADVYAPLSGKIveVNEKldtepelinkdpe 104 Thermotoga maritima
2EJM_A     16 GPLAPm-------TGTIe-------kVFVKaGDKVKAGDSLMVMIAmKMEHTIKSPKDGTVkkVFYRegaq-------an 74  human
1BDO_A      6 IVRSPm-------VGTFyrtpspdakAFIEvGQKVNVGDTLCIVEAmKMMNQIEADKSGTVkaILVEsgqp-------ve 71  Escherichia coli
2PNR_G     29 QVLLPalsp-tmtMGTVq-------rWEKKvGEKLSEGDLLAEIETdKATIGFEVQEEGYLakILVPegtr------dvp 94  human
1HPC_A     24 TIGITdhaqdhlgEVVFv--------ELPEpGVSVTKGKGFGAVESvKATSDVNSPISGEVieVNTGltgkpglinsspy 95  pea
Feature 1             
1DCZ_A     69 gGQGLIKI 76  Propionibacterium freudenreichii
1PMR_A     69 sRQILGRL 76  Escherichia coli
1ZKO_A    105 gEGWLFKX 112 Thermotoga maritima
2EJM_A     75 rHTPLVEF 82  human
1BDO_A     72 fDEPLVVI 79  Escherichia coli
2PNR_G     95 lGTPLCII 102 human
1HPC_A     96 eDGWMIKI 103 pea

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