Conserved Protein Domain Family
SURF1

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cd06662: SURF1 
SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring complex of the respiratory chain, is an assemblage of nuclear and mitochondrially-encoded subunits. Its assembly is mediated by nuclear encoded assembly factors, one of which is Surf1/Shy1. Mutations in human Surf1 are a major cause of Leigh syndrome, a severe neurodegenerative disorder.
Statistics
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PSSM-Id: 119401
View PSSM: cd06662
Aligned: 196 rows
Threshold Bit Score: 78.9247
Threshold Setting Gi: 85373378
Created: 8-Jan-2008
Updated: 2-Oct-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
P53266        84 SFYLGTWQVRRLKWKTKLIAACet---------klTYEPIPLPksftpd-------------mcedweYRKVILTGHFLH 141 baker's yeast
YP_057001     38 MVFLGLWQMNVFESQRDDSTQAr-----------iNGPVITWNeapkka-------------dvmaqyGRRVTVTGTFQR 93  Propionibacteri...
YP_001792844  26 TARLGFWQLDRGDQKSRLQTQIet---------rqQLPPLDRSelapdad------------taatqfDRQVQLQGRWVP 84  Leptothrix chol...
AAV66318       9 CVRLGFWQLDRAAAKQALRAEVaa---------raALPPLAAAalaatpe------------aaaaqhYRRVTLAGRWLA 67  Rubrivivax gela...
YP_001022364  72 TARLGAWQLSRAAEKEALQASLdt---------rgALPPLPAValardaa------------taagqwHRRITLAGRWRP 130 Methylibium pet...
YP_972219     35 TAALGRWQLARAAEKQAWQAMIda---------rqAMPPVPAAalaslppvagpesgspampaaealvHRPAVLRGRWLA 105 Acidovorax aven...
ZP_01517834   26 TASLGFWQLSRAAHKQAVFDAIerqqalepwhnaeLAAEVALAaestgea------------qkatllHRPVQLRGQWLA 93  Comamonas testo...
YP_001562709  21 TLSLGRWQLQRAAYKQQLFDAVqr---------qqGLPPLDNAqlapmqpgaa------lnteaapwlHRPVRLQGHWIA 85  Delftia acidovo...
YP_522947      4 TLALGRWQLSRAAQKVAMQAGMea---------ksTMSILDGRvlaara-------------dpalelHRRVALRGQWIP 61  Rhodoferax ferr...
YP_548100     24 TFSLGQWQLRRAAQKEALHAAVea---------knGLSPLDNQtffaik-------------dianetHRRVSIQGVWQP 81  Polaromonas sp....
P53266       142 neemfvgprkKNGEKGYFLFTPFIRDdtg---ekVLIERGWISEEkvapdsrnlhhlslpqeehlkVVCLVRppkkRGSL 218 baker's yeast
YP_057001     94 stt-----tlIGTSWPVRVVTGIKLTtg----etMAIVRGKLSKGervpaa---------ptgvitVTGVLAaseaDDGR 155 Propionibacteri...
YP_001792844  85 qgtvflenrqMHGRPGFFVVTPLLLDhg----daVMVQRGWVPRDgldrtrlpe---iatpdglqtLRGRMApppaRLYD 157 Leptothrix chol...
AAV66318      68 drtvaldnrqVDGRPGFVLVTPLVLAdg----saVAVQRGWLPRDaaersriaa---pplpaalvqVAGQLApppsRLFA 140 Rubrivivax gela...
YP_001022364 131 ehsvfldnrqMNGRPGFFLLTPLELApg----daVLVQRGWAPRDlrdrallpd---vptaggrveLVGQIApapaRLYA 203 Methylibium pet...
YP_972219    106 qdtvfldnrqMQGRPGFFVVTPLRLTspgaegavVLVQRGWVPRDfqdrtrlpa---vpapsedveVHGRIAaapsRLYE 182 Acidovorax aven...
ZP_01517834   94 eqtlfldnrqMQGRAGFYVLTPFRLSapha-nrvVVVQRGWAPRNfmdrsvlpe---vqtpagtvsIEGRLEappsRLME 169 Comamonas testo...
YP_001562709  86 gqslyldnrqMQGQPGFFVLTPLRLAaphe-dvvIAVQRGWVPRNfldrtalpe---vqtpeglvtVEGRMEaapsRLYE 161 Delftia acidovo...
YP_522947     62 ertvfldnrpMNGRTGLYVVTPMRLEgsa---avVLVQRGWVARNfmdrshlpt---iespagvreIVGRIApppaKLYE 135 Rhodoferax ferr...
YP_548100     82 ahtiyldnrpMGGKTGFWVLTPLALQgss---qvVLVQRGWVPRDftrrtrlpe---vstpaglvtVEGRIApppsKLYE 155 Polaromonas sp....
P53266       219 QWAkkdpnsrl------wqvpdiydMARSSGctpiqfqalydmkdhpiieehtrneasqnnstsslwkfwkrepttavng 292 baker's yeast
YP_057001    156 RNSqmpaavl--------pslrlevLTQTWPqplvpatltldkknal--------------------------------- 194 Propionibacteri...
YP_001792844 158 FGDagsgpi-----------rqnldLAAHAGslglrlrpwsvlqtdpv-------------------------------- 194 Leptothrix chol...
AAV66318     141 FGAdapgaair-------qnldlgaWSAEIGvplrplslvqldgprt--------------------------------- 180 Rubrivivax gela...
YP_001022364 204 FADeesgrlr--------qnividaYARETGlglrplsivqteggv---------------------------------- 241 Methylibium pet...
YP_972219    183 PGGpasaagsegss-rirqnldlaaYRAETGlqrlapltvietggp---------------------------------- 227 Acidovorax aven...
ZP_01517834  170 LETanggadpdeqqsrirqnadialWAQQGGlpllalsvvqsgsa----------------------------------- 214 Comamonas testo...
YP_001562709 162 FGRagadpdgqks--rirqnvdiaeWAVASGlplrewsllqtgea----------------------------------- 204 Delftia acidovo...
YP_522947    136 LSGsdtglir--------qnidlagLAVETGlallpvsvqqtgaa----------------------------------- 172 Rhodoferax ferr...
YP_548100    156 FKGedagrir--------qnldlnaFRVETGlpllgvallqtgap----------------------------------- 192 Polaromonas sp....
P53266       293 tqavdnntskprsrqemptdqtiefderqfikagvpigrkptidlKNNHLQYLVTWYGLSFLSTIF 358 baker's yeast
YP_057001    195 -----------------------------aqglapaqpvlpkgdgGERNRGYALQWWVFAIFTVAM 231 Propionibacterium acnes KPA17...
YP_001792844 195 ----------------------------aasesplqrdwpspatgVQKHLGYATQWFALSALTAGL 232 Leptothrix cholodnii SP-6
AAV66318     181 ------------------------------psdglrremplpsadVSRHQVYAGQWFLFAALAVVL 216 Rubrivivax gelatinosus
YP_001022364 242 ------------------------------pedgllrqwprpavdVHKHYGYAFQWFALATLLTGL 277 Methylibium petroleiphilum PM1
YP_972219    228 -------------------------------egplqrdwpavdagVARHHGYAFQWFGLCALVAIL 262 Acidovorax avenae subsp. citr...
ZP_01517834  215 -------------------------------segllrdwpqinagVQKHYGYAFQWFGLSVLVVLL 249 Comamonas testosteroni KF-1
YP_001562709 205 -------------------------------seglrrdwpvvtagVEKHHGYAFQWFGLAALITLL 239 Delftia acidovorans SPH-1
YP_522947    173 -------------------------------gdgmlrdwpqpavgVEKHYGYAFQWFALSSLIAIL 207 Rhodoferax ferrireducens T118
YP_548100    193 -------------------------------gegllrewaapnlgVDKHYGYAFQWFALCSLVVVL 227 Polaromonas sp. JS666
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