1S9I,1S9I


Conserved Protein Domain Family
PKc_MEK2

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cd06649: PKc_MEK2 
Click on image for an interactive view with Cn3D
Catalytic domain of the dual-specificity Protein Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase 2
PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (ST) or tyrosine residues on protein substrates. MEK2 is a dual-specificity PK and a MAPK kinase (MAPKK or MKK) that phosphorylates and activates the downstream targets, ERK1 and ERK2, on specific threonine and tyrosine residues. The ERK cascade starts with extracellular signals including growth factors, hormones, and neurotransmitters, which act through receptors and ion channels to initiate intracellular signaling that leads to the activation at the MAPKKK (Raf-1 or MOS) level, which leads to the transmission of signals to MEK2, and finally to ERK1/2. The ERK cascade plays an important role in cell proliferation, differentiation, oncogenic transformation, and cell cycle control, as well as in apoptosis and cell survival under certain conditions. Gain-of-function mutations in genes encoding ERK cascade proteins, including MEK2, cause cardiofaciocutaneous (CFC) syndrome, a condition leading to multiple congenital anomalies and mental retardation in patients. The MEK subfamily is part of a larger superfamily that includes the catalytic domains of other protein serine/threonine kinases, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.
Statistics
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PSSM-Id: 132980
View PSSM: cd06649
Aligned: 4 rows
Threshold Bit Score: 655.581
Threshold Setting Gi: 94732519
Created: 15-Nov-2007
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 22 residues -Click on image for an interactive view with Cn3D
Feature 1:ATP binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                 ##### # #            # #                             #              
1S9I_B     12 ELKDDDFERISELGAGNGGVVTKVQHRPSgLIMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISI 91  human
Q90891     64 ELKDDDFERISELGAGNGGVVTKVQHKPSgLIMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISI 143 chicken
CAK04317   63 ELKDEDFEPICELGAGNGGVVHKVRHKPSrLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISI 142 zebrafish
1S9I_A     12 ELKDDDFERISELGAGNGGVVTKVQHRPSgLIMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISI 91  human
Feature 1      ####  ##  #                                      # ## #          #             
1S9I_B     92 CMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRGLAYLREkHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMAN 171 human
Q90891    144 CMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRGLAYLREkHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMAN 223 chicken
CAK04317  143 CMEHMDGGSLDQVLKEARRIPEEILGKVSIAVLRGLAYLREkHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMAN 222 zebrafish
1S9I_A     92 CMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRGLAYLREkHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMAN 171 human
Feature 1                                                                                     
1S9I_B    172 SFVGTRSYMAPERLQGtHYSVQSDIWSMGLSLVELAVGRYPIPPPDAKELEAIFGRPVVDGEEGEPHSISPRPRPPGRPV 251 human
Q90891    224 SFVGTRSYMSPERLQGtHYSVQSDIWSMGLSLVELSIGRYPIPPPDSKELEAIFGRPVVDGAEGESHSVSPWARPPGRPI 303 chicken
CAK04317  223 SFVGTRSYMSPERLQGtHYSVQSDVWSMGLSLVELAIGRYPIPPPDAKELEAIFGRPVLDAGGAEGHSMSPRPRPPGRPV 302 zebrafish
1S9I_A    172 SFVGTRSYMAPERLQGtHYSVQSDIWSMGLSLVELAVGRYPIPPPDAKELEAIFGRPVVDGEEGEPHSISPRPRPPGRPV 251 human
Feature 1                                                                                     
1S9I_B    252 sghgmDSRPAMAIFELLDYIVNEPPPKLPNGvFTPDFQEFVNKCLIKnPAERADLKMLTNHTFIKRSEVEEvDFAGWLCK 331 human
Q90891    304 sghgmDSRPAMAIFELLDYIVNEPPPKLPNGvFTQDFQEFVNKCLIKnPAERADLKMLMNHTFIKRSEVEEvDFAGWLCK 383 chicken
CAK04317  303 sghgmDSRPAMAIFELLDYIVNEPPPKLPHGvFTTDFEEFVTKCLIKnPADRADLKMLMGHTFIKRAEVEEvDFAGWLCK 382 zebrafish
1S9I_A    252 sghgmDSRPAMAIFELLDYIVNEPPPKLPNGvFTPDFQEFVNKCLIKnPAERADLKMLTNHTFIKRSEVEEvDFAGWLCK 331 human
Feature 1                
1S9I_B    332 TLrLNQPGTPT 342 human
Q90891    384 TLrLNQPSTPT 394 chicken
CAK04317  383 TMgLHQPSTPT 393 zebrafish
1S9I_A    332 TLrLNQPGTPT 342 human

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