Conserved Protein Domain Family
PKc_MAPKK_plant_like

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cd06623: PKc_MAPKK_plant_like 
Catalytic domain of Plant dual-specificity Mitogen-Activated Protein Kinase Kinases and similar proteins
PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (ST) or tyrosine residues on protein substrates. Members of this group include MAPKKs from plants, kinetoplastids, alveolates, and mycetozoa. The MAPKK, LmxPK4, from Leishmania mexicana, is important in differentiation and virulence. Dictyostelium discoideum MEK1 is required for proper chemotaxis; MEK1 null mutants display severe defects in cell polarization and directional movement. Plants contain multiple MAPKKs like other eukaryotes. The Arabidopsis genome encodes for 10 MAPKKs while poplar and rice contain 13 MAPKKs each. The functions of these proteins have not been fully elucidated. There is evidence to suggest that MAPK cascades are involved in plant stress responses. In Arabidopsis, MKK3 plays a role in pathogen signaling; MKK2 is involved in cold and salt stress signaling; MKK4/MKK5 participates in innate immunity; and MKK7 regulates basal and systemic acquired resistance. The MAPKK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.
Statistics
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PSSM-Id: 132954
View PSSM: cd06623
Aligned: 28 rows
Threshold Bit Score: 323.775
Threshold Setting Gi: 67605389
Created: 4-Apr-2007
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
Feature 1:active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                   #####   #            # #                                 #         
Q9S7U9      68 SDLDMV-----KVIGKGSSGVVQLVQHkwtgQFFALKVIQLNide--aiRKAIAQELKINQSSq--CPNLVTSYQSFYDn 138  thale cress
XP_822772   53 VLVNNT-----SFLGRGSSGSVRRATHrktgKEIALKEIKFTgq---trMMEIRRELETLHRGggpSPYLVDFYGAFCHe 124  Trypanosoma bruc...
EAS05692   280 SELRRV-----KVLGHGSSGLVELAVHdatgIVIGIKSIPLLmns--sfRKQLDQELKTLIQCe--SDSIVKCYGAYIQk 350  Tetrahymena ther...
CAK76127    92 IQLQDLis--iDDLGQGSSGRVIKALHrptnLLVALKTIQVVnde--kfTKQINLELETLVSCd--HSNIIRCYGAFLEg 165  Paramecium tetra...
CAJ09039    52 SDLEVVpetagGFLGKGSSGSVRRAVHrgskKMVAVKEIKVTgq---thINEIRRELETLHAGdfaTPYLVSFYGAFAHe 128  Leishmania major
CAL51803    15 ADLELV-----GVIGTGSGGVVRLATHkrtgEALAVKTIAISlardeneRKRIVTELRTLHKSe--CDYIVRSSGAYFDr 87   Ostreococcus tauri
CAJ07921    56 ENLKRV-----RQLGQGTQGNVSMYVTad-kSVFAVKKITIPvtldtrtRQTVAAELRNIFSAq-sNEYTVNLYNAFYRn 128  Leishmania major
AAX69304    72 EDLQTR-----HVLGKGSQGKVKLVRHrptgKTYALKYIHLDgdt-dnmREALESELRQVRAVr--HRNVVTSYEAYFRe 143  Trypanosoma brucei
XP_807996   55 DSLDCV-----KCLGKGTQGKVSKCINqkdgAVYAVKRLLIPrttdrmnKSTVAGELRNIFSQg-tNAYTVELYNAFYKd 128  Trypanosoma cruz...
CAK90252    70 ENLVTV-----GQLGQGASGQVEKVQDqvtgQYFAMKKIPVAsdp--qyLKQLSDELKLALECs--SPYVVKCYGAFYKs 140  Paramecium tetra...
Feature 1            ####  ##  #                                                 # #### #      
Q9S7U9     139 gAISLILEYMdgGSLADFLksv-kaiPDSYLSAIFRQVLQGLIYLHHd------------RHIIHRDLKPSNLLINh-rG 204  thale cress
XP_822772  125 gSVFIAMECMd-GSLDGVAgs----vPPKVLECITRSILRGLSYLHKd------------RHLIHRDIKPSNILYSr-dG 186  Trypanosoma bruc...
EAS05692   351 cMINITLEYMdlGTVHDLVkkv-gplPEIIVAIMAIQVLKGLDYIHNk------------AKVIHRDIKPSNLLVNs-kG 416  Tetrahymena ther...
CAK76127   166 aQVAIALEFMnlGTLQDVIkks-gkiPEGMLGLIAYQLLKGLDYLHRt------------KKIIHRDIKPSNLLINs-aG 231  Paramecium tetra...
CAJ09039   129 gSVFIAMEAMd-GSLHELYkp----vPPPVLASITRLMLKGLTYLHRt------------RHLIHRDLKPSNVLYNsrtG 191  Leishmania major
CAL51803    88 gSVSLVMEYMdgGTMSDATkyl-gkwVEQDLAAATSMLADGLHYLHTk------------LNVVHRDIKPCNVLLNl-rG 153  Ostreococcus tauri
CAJ07921   129 rALRLVMEYMdwGNIDELIaek-vkiPPTVCGYIASQMLHALAVLHTksnivtepnqhksLRQIHRDIKPANVLLSt-tG 206  Leishmania major
AAX69304   144 gRLYIVLEYMdaGSMADILkrrsnhfTEEMLAYVARELLYGVEHLHS-------------LKMIHRDIKPVNVLANs-yG 209  Trypanosoma brucei
XP_807996  129 gTLSLVMEYMdwGNLEELIaic-ptiPEPACAYIASQILHALQILHTkanhpt-etdqkgRRQIHRDIKPANVMLSk-nG 205  Trypanosoma cruz...
CAK90252   141 gTLHIILEYMdvGSIDSLIkkv-knlNEPVMALLLYQILLGIDYLHNk------------KKIIHRDIKPQNILVNk-kG 206  Paramecium tetra...
Feature 1          ##  #             #### #                          #        #                
Q9S7U9     205 EVKITDFGVSTVMTNTAGLanTFVGTYNYMSPERIVGnKYGNKSDIWSLGLVVLECAtgKFPYAPpnqee---twtsVFE 281  thale cress
XP_822772  187 SIKISDFGASSCLECTRGNafSFVGTLTYMSPERLKGePYSFPADIWSLGLAVAELAlgKCPFIDrlsrangstegcFWV 266  Trypanosoma bruc...
EAS05692   417 QVKIADFGVSANLESAVEVk-NWVGTVTYMSPERFRGqAYTANTDIWSLGLTICECAlgTYPYFDsnqyek-kenlsFWE 494  Tetrahymena ther...
CAK76127   232 EVKISDFGVSGQLLNTQDQrsTWVGTVTYMSPERFLCePYSSNTDVWSLGLSLLECAwgVFPYPHpgtnet-tpslgFWE 310  Paramecium tetra...
CAJ09039   192 DIKISDFGVSSNLECTKADahSFVGTVTYMSPERLRGeHYSYGADIWSLGLVVAELAvgVCPYAGlrggs---searFWA 268  Leishmania major
CAL51803   154 EAKLSDFGVSGHLTDASKCh-SWVGTVTYMSPERIQGeSYEYTADVWSFALTMVECAlgRFPYNPpdvs----rrlvFWD 228  Ostreococcus tauri
CAJ07921   207 CVKLADFGIATSAETIGVN--SFVGTATYMSPERIQGrRYSTPSDIWSVGVVVAQMLlgHYPFSSvg--------kgFMA 276  Leishmania major
AAX69304   210 EVKIADFGVAKKLSDGGEGtmSAQGSVIYMSPERINGeLYSFSSDIWSVGLTIAECAlgVYPFTSlk--------nnIFD 281  Trypanosoma brucei
XP_807996  206 VVKLTDFGIAASTETIGVN--SFVGTATYMSPERIQGrTYSTPSDIWSVGVLTAQLLlgHFPFSAae--------ggFMA 275  Trypanosoma cruz...
CAK90252   207 EIKITDFGISGTIETMQQRk-TYVGTAVYMSPERLNGeMYGRDSDIWSIGILTAECLmgKHPIQKt----------qFID 275  Paramecium tetra...
Feature 1                                                                  
Q9S7U9     282 LMEAIV-DQPPPALPSGn--FSPELSSFISTCLQKdPNSRSSaKELMEHPFL---NKYDY 335  thale cress
XP_822772  267 LLQHLNgDGPVISLPSS---MNASMTDFITTCIQRePSKRPTcDELRRHPFV---AEGDE 320  Trypanosoma brucei TREU927
EAS05692   495 LLEYFN-MKPAPRLPEN---YSEEMKDFVAKCFKKsPLDRPHsHDLLNHEMV---KKFSQ 547  Tetrahymena thermophila SB210
CAK76127   311 IKEYIV-SRPAPPSPPE---FSQMGADFIAMCLQKdPRKRRSaAELLEHPFI---KQYED 363  Paramecium tetraurelia
CAJ09039   269 LLQHLNgDGAALELPPE---MDSDLADFISACVVKsPDRRPTcTELLRHPFIv--RHTAA 323  Leishmania major
CAL51803   229 LLDIVV-QDPVPNLRPEl-dVSDEFDNFVALGLNKdPTGRMLtKNMIAHPWI---FGRDR 283  Ostreococcus tauri
CAJ07921   277 LLREIN-SVEKYPLMEEt-gCSQEAQDFIDSCLRQdPDDRSSaFELLESPWI---KYCEE 331  Leishmania major
AAX69304   282 LLQAIAtRTASIDWKSTgreHSAQLIDFVNHCLLP-AASRPSaRELLQHPLI---QVAEG 337  Trypanosoma brucei
XP_807996  276 LLRQVT-ECCSLSLVDQc-aCSQKAENFINHCICRnPDDRSTaTELLQHEWIv--QNASN 331  Trypanosoma cruzi strain CL Brener
CAK90252   276 MVNEIS-SFNIESVQAK---ISAEMKNFISMCVKLkPEERATvDQLLNHKIIlrtKKIDK 331  Paramecium tetraurelia

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