Conserved Protein Domain Family
PKc_PBS2_like

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cd06622: PKc_PBS2_like 
Catalytic domain of fungal PBS2-like dual-specificity Mitogen-Activated Protein Kinase Kinases
PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (ST) or tyrosine residues on protein substrates. Members of this group include the MAPKKs Polymyxin B resistance protein 2 (PBS2) from Saccharomyces cerevisiae, Wis1 from Schizosaccharomyces pombe, and related proteins. PBS2 and Wis1 are components of stress-activated MAPK cascades in budding and fission yeast, respectively. PBS2 is the specific activator of the MAPK Hog1, which plays a central role in the response of budding yeast to stress including exposure to arsenite and hyperosmotic environments. Wis1 phosphorylates and activates the MAPK Sty1 (also called Spc1 or Phh1), which stimulates a transcriptional response to a wide range of cellular insults through the bZip transcription factors Atf1, Pcr1, and Pap1. The PBS2 subfamily is part of a larger superfamily that includes the catalytic domains of STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.
Statistics
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PSSM-Id: 132953
View PSSM: cd06622
Aligned: 4 rows
Threshold Bit Score: 513.242
Threshold Setting Gi: 28189093
Created: 16-Nov-2007
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
Feature 1:active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1             #####   #            # #                             #               ###
P08018    358 DELEFLDELGHGNYGNVSKVLHkptnVIMATKEVRLELDeakFRQILMELEVLHKCnSPYIVDFYGAFFIegAVYMCMEY 437 baker's yeast
BAC56235  289 DEVEVMDELGKGNYGTVYKVRHs---KVMAMKEIRLELDeskFSTILKELVILHECaSPYIIDFYGAFYQegAVYMCIEY 365 Neurospora crassa
P33886    318 SEIIKLEELGKGNYGVVYKALHqptgVTMALKEIRLSLEeatFNQIIMELDILHKAvSPYIVDFYGAFFVegSVFICMEY 397 fission yeast
AAW41278  293 DEIEVLGELGKGNYGSVHKVFHrptgVTMAMKEIRLELDdskLNGIIMELDILHRAvAPEIVEFYGAFTIesCVYYCMEY 372 Cryptococcus neofo...
Feature 1     #  ##  #                                                   # #### #          ## 
P08018    438 MdgGSLDKIYdesse------------iggiDEPQLAFIANAVIHGLKELKEqHNIIHRDVKPTNILCSanqGTVKLCDF 505 baker's yeast
BAC56235  366 MdgGSIDKLYag-----------------giPENVLRKITYATIMGLKCLKEdHNIIHRDVKPTNILVNt-nGQVKICDF 427 Neurospora crassa
P33886    398 MdaGSMDKLYagg----------------ikDEGVLARTAYAVVQGLKTLKEeHNIIHRDVKPTNVLVNs-nGQVKLCDF 460 fission yeast
AAW41278  373 MdaGSLDSLTgggvaakdqtkeeeddatervPEDVLRRITARIVKGLRFLKDeLQIIHRDVKPTNVLINg-kGEVKMCDF 451 Cryptococcus neofo...
Feature 1      #           #### #                                     #        #              
P08018    506 GVSGNLVASLAKTNIGCQSYMAPERIKSlnp------draTYTVQSDIWSLGLSILEMAlgRYPYPPEtydnIFSQLSAI 579 baker's yeast
BAC56235  428 GVSGNLVASIAKTNIGCQSYMAPERISGggmsaaggaaagTYSVQSDIWSLGLTIIECAmgRYPYPPEvsstIFSQLSAI 507 Neurospora crassa
P33886    461 GVSGNLVASISKTNIGCQSYMAPERIRVggpt----ngvlTYTVQADVWSLGLTILEMAlgAYPYPPEsytsIFAQLSAI 536 fission yeast
AAW41278  452 GVSGQLEKSLAKTNIGCQSYMAPERIKSetan-----qnpTYTVSSDVWSVGLSIVELAkgCYPYPPEtyanVFAQLQAI 526 Cryptococcus neofo...
Feature 1                                                                                     
P08018    580 VdgPPPRLPSDkFSSDAQDFVSLCLQKiPERRPTyAALTEHPWLVKYRNq------------------------------ 629 baker's yeast
BAC56235  508 VegDPPGLPSEgYSGTAQDFVKSCLNKiPAKRHTyPMLLMHPWIKSLGRpetiteeveaeekaaddqladatgsldinsn 587 Neurospora crassa
P33886    537 CdgDPPSLPDS-FSPEARDFVNKCLNKnPSLRPDyHELANHPWLLKYQNa------------------------------ 585 fission yeast
AAW41278  527 VhgTPPTLPPG-YSDDANDFVAKCLEKdPNRRPTyAQLLEHPFLVADKGa------------------------------ 575 Cryptococcus neofo...
Feature 1                           
P08018    630 -------dVHMSEYITERLERR 644 baker's yeast
BAC56235  588 gpindqgdREVAEWVTNVLDRK 609 Neurospora crassa
P33886    586 -------dVDMASWAKGALKEK 600 fission yeast
AAW41278  576 -------eVDMVGWVEGALKRK 590 Cryptococcus neoformans var. neoformans JEC21

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