3COM


Conserved Protein Domain Family
STKc_MST1_2

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cd06612: STKc_MST1_2 
Click on image for an interactive view with Cn3D
Catalytic domain of the Serine/Threonine Kinases, Mammalian STe20-like protein kinase 1 and 2
STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of MST1, MST2, and related proteins including Drosophila Hippo and Dictyostelium discoideum Krs1 (kinase responsive to stress 1). MST1/2 and Hippo are involved in a conserved pathway that governs cell contact inhibition, organ size control, and tumor development. MST1 activates the mitogen-activated protein kinases (MAPKs) p38 and c-Jun N-terminal kinase (JNK) through MKK7 and MEKK1 by acting as a MAPK kinase kinase kinase. Activation of JNK by MST1 leads to caspase activation and apoptosis. MST1 has also been implicated in cell proliferation and differentiation. Krs1 may regulate cell growth arrest and apoptosis in response to cellular stress. The MST1/2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.
Statistics
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PSSM-Id: 132943
View PSSM: cd06612
Aligned: 23 rows
Threshold Bit Score: 434.386
Threshold Setting Gi: 66811352
Created: 2-Aug-2006
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 20 residues -Click on image for an interactive view with Cn3D
Feature 1:ATP binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                   #####   #                   # #                               #       
3COM_A         27 PEEVFDVLEKLGEGSYGSVYKAIHKe-------tGQIVAIKQVPVEsd----lQEIIKEISIMQQC-DSPHVVKYYGSYF 94   human
XP_644702      38 GETSFEIQEKLGEGSFGSVYRAIHKs-------sNTSIAIKEFEIFean--dvEPISKEIQILKKC-NNPYVVSYFGSIM 107  Dictyostelium...
XP_644216     390 GHNDFILDEKLGDGAYGSVYKGTHKd-------lGFTLAIKVIEMKes---esVSLQNEINILKNC-KSPNIVSYFGSLQ 458  Dictyostelium...
XP_628883     646 VEDTFEFKEKLGQGGYGAVFKVLHRe-------tNFPLAIKVLSITpt---riKDIEKEIDLLKKC-RCPNVLSYYGSIS 714  Dictyostelium...
CAK63242        8 PEDSYRLEGVIGEGSYGQVYKATQLe-------nGKVVAIKIVPTTge----iESLKREIQILRDC-RSDNIVKYFGSYH 75   Paramecium te...
CAK91506        7 PEEQFELNELIGQGAYAKVYKGRHKn--------GQIVAIKIVPSNge----iQSLIKEIQILKQEcQHAHIVQYYGSFY 74   Paramecium te...
XP_001021866    9 PEEIFDIICILGQGNYGKVFKALCKq-------dKKEYAIKVMLVNed----iFQISKEISILQNC-KNQNIVGYFGSFF 76   Tetrahymena t...
XP_636883      17 PEQLFRVLEVIGQGSFGVVCTCINTv-------nNEVVAIKFLEMEge---enSSLKKEITILKNTvRCPYIVKYHGCYI 86   Dictyostelium...
XP_635106      19 PEAIFQIVEVVGSGSFGTVCACRWMkkkdresngNRLIACKFVEVNaddvetnLNLVKEIDILKESmDCPYIVEYKGCYL 98   Dictyostelium...
XP_001029922   17 PEEIFEILDLLGEGSYGQVYKALHKq-------tGELVAVKMVPNEg-----dSALEKEIRMLKEC-QSEYVVKYYASYY 83   Tetrahymena t...
Feature 1                  ####  ##  #                                           ## #          #  
3COM_A         95 Kn-tDLWIVMEYCGaGSVSDIIRLRn---KTLTEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFG 170  human
XP_644702     108 Lk-nKYWILMDYCSlSSFNDIMQSIg---KTFKEKEISLILQQSLLGLVYLHSKQIIHRDIKSANILLDETGQVKIADFG 183  Dictyostelium...
XP_644216     459 Te-sHIWILLDFCAlGSIRDIIESTe---KTLNEAQISFVVKNTLKGLIYLHSQNIIHRDVKAANVLLSEGCDVKIADFG 534  Dictyostelium...
XP_628883     715 SkltELWILMDHCAvGSINDMMKICc---DTLDEEQIAVVTLNVLNGLGYLHSKGIVHLDVKAANILLTEDKQIKIADFG 791  Dictyostelium...
CAK63242       76 Sn-gQLWLVMEYCAgGSVIDLVKAMsfngSSLPEELIATILYQTLKGIDYMHNHKKIHRDIKCGNILIDHIGNIKLADFG 154  Paramecium te...
CAK91506       75 Kd-gNLWLVMEYCVgGSIIDLLKITq---KTLTESEIAAILYHVLLGIEYLHANKKIHRDIKAGNILLDEKGTIKIADFG 150  Paramecium te...
XP_001021866   77 Kd-nAIWLVTEYCEgGSALDLIKIIq---RTFNEQEISAILYQALLGLQYLHDNKKIHRDIKAGNILLNEKGEAKLADFG 152  Tetrahymena t...
XP_636883      87 Ke-nNLMIVMEYCDgGSILDIMQMCs---ITLTEAQIAAILYQIVEGLVYLHSNKILHRDIKAGNVLVNKLGQAKLADFG 162  Dictyostelium...
XP_635106      99 Ks-sMLLIVMEYCKgGSLLDIIELCg---KRLIEEEIAAVCAGVVKGLVYLHSKRTTHRDIKAGNVLLDEEGLPKLADFG 174  Dictyostelium...
XP_001029922   84 Kd-qHLWLIMEYCAaGSIIDLVKITr---IQLNEQQIASILQSTLKGLQYLHSNKIIHRDIKAGNILLDQRGNAKLADFG 159  Tetrahymena t...
Feature 1                                                                                         
3COM_A        171 VAGQLTDXMaKRNXVIGTPFWMAPEVIQEi----gYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPTNPPPTFR 246  human
XP_644702     184 VSQQIQSTF-SKGSIAGTPYWMAPEILNQt----dYNNKIDVWSLGIVAIELADGEPPLSEVNPMRAMYMIGRRPPPTFK 258  Dictyostelium...
XP_644216     535 VSEKLNGALdQSKEMIGTPLWMAPEVILKk----nYDYKADIWSLGITIIEMADGLPPHIDLPPMRAMKMVPNWPPPTFA 610  Dictyostelium...
XP_628883     792 VSQQLQTEYgQANVYIGSPLYMAPEVILKa----pYNSKADIWSLGITLIELAEGRPPNRGLRSMNQLVEIPNMPPPKLS 867  Dictyostelium...
CAK63242      155 VSTQLVHTMaDTDTVIGSPFWMSPEILLKs----rYNKKTDIWSLGITAIEMAEGEPPYAHIHPIRAMFAIKNNPPNSLT 230  Paramecium te...
CAK91506      151 VAAQLIYTNaDKGTVIGTPVYMSPEVISKn----rYNHLTDIWSLGVTAIELAEGKPPYSHIHPVRAMFAIKNNPPQGLT 226  Paramecium te...
XP_001021866  153 VSAEQTYTNaEKQTLMGTPYWMSPEVLGNs----kYNNKTDIWSLGITAIELAEGEPPYSNIHPFRAMFAIKKNPPQGLS 228  Tetrahymena t...
XP_636883     163 VSAILVNTGfKQKTVVGSPYWMSPEVISPpkgsngYDSKADIWSLGITAIEMAESKPPLFNLNPVKVIFVIPFRQAPTLE 242  Dictyostelium...
XP_635106     175 VSTIAEQGQ-KMNTVIGSPYWMAPEIIMGq----gYDQKADIWSLGITAIEIAELVPPRFDVPPSRVIFTIPHQPPPSLK 249  Dictyostelium...
XP_001029922  160 VSFQQIHTQaKAESKIGTPCWMAPEVIMHl----kYDSKADIWSLGITAIELAEGEPPYSDVKPSMVMAKIQQKPPQGLK 235  Tetrahymena t...
Feature 1                                             
3COM_A        247 KPElWSDNFTDFVKQCLVKsPEQRATATQLLQHPFV 282  human
XP_644702     259 DPKkWSPEFVSFVDKCLTKdINERWSPSQLLDHPFI 294  Dictyostelium discoideum AX4
XP_644216     611 EPKkWSPLLNDFLARCLVKdPEKRASPIDLLCHPFL 646  Dictyostelium discoideum AX4
XP_628883     868 NPKdWSPCFNNFLATCLVKdPVQRPSVIDLLSHDFI 903  Dictyostelium discoideum AX4
CAK63242      231 DQTrWSKEFNAFVKKCLILdPKERPSTKELLQDPFF 266  Paramecium tetraurelia
CAK91506      227 NPEkWSKEFNDFVKSCLRVqVSERPSAQQLLQSPFI 262  Paramecium tetraurelia
XP_001021866  229 NPTqWSQEFSDFVKKCLTLdSNLRPSAKDLLSHPFI 264  Tetrahymena thermophila
XP_636883     243 VPGnWSPEFNDFISVCLNKeADKRPSAVDLLNHPFI 278  Dictyostelium discoideum AX4
XP_635106     250 IPSdWSPEFNDFVKQCLSMnPALRPSAQQLLSHPFI 285  Dictyostelium discoideum AX4
XP_001029922  236 NPSqWSQQFNDFVKQCLQQdPQKRPTAEQLLQHPFI 271  Tetrahymena thermophila

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