2J7T,2J51


Conserved Protein Domain Family
STKc_SLK_like

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cd06611: STKc_SLK_like 
Click on image for an interactive view with Cn3D
Catalytic domain of Ste20-Like Kinase-like Serine/Threonine Kinases
STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Members of the subfamily include SLK, STK10 (also called LOK for Lymphocyte-Oriented Kinase), SmSLK (Schistosoma mansoni SLK), and related proteins. SLK promotes apoptosis through apoptosis signal-regulating kinase 1 (ASK1) and the mitogen-activated protein kinase (MAPK) p38. It also plays a role in mediating actin reorganization. STK10 is responsible in regulating the CD28 responsive element in T cells, as well as leukocyte function associated antigen (LFA-1)-mediated lymphocyte adhesion. SmSLK is capable of activating the MAPK Jun N-terminal kinase (JNK) pathway in human embryonic kidney cells as well as in Xenopus oocytes. It may participate in regulating MAPK cascades during host-parasite interactions. The SLK-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.
Statistics
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PSSM-Id: 132942
View PSSM: cd06611
Aligned: 7 rows
Threshold Bit Score: 518.529
Threshold Setting Gi: 167537886
Created: 2-Aug-2006
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 23 residues -Click on image for an interactive view with Cn3D
Feature 1:ATP binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                     #####   #             # #               #             #             
2J7T_A         15 LDPNEVWEIVGELGDGAFGKVYKAKNke-tGALAAAKVIETkseEELEDYIVEIEILATCd-HPYIVKLLGAYYhdgkLW 92   human
2J51_A         33 LNPEDFWEIIGELGDGAFGKVYKAQNke-tSVLAAAKVIDTkseEELEDYMVEIDILASCd-HPNIVKLLDAFYyennLW 110  human
AAN72832       28 VNPTDIWEIISELGDGAFGKVYKTHKrn-tDLFAALKRVDFeseDELEDFMLEIDILTNFk-HKNILTLHEVYIyeskLW 105  Schistosoma m...
NP_510290      28 VNPRDHWNIIGELGDGAFGKVEKAVSrtdpKLFAASKSIEIqegEELEDFLVEIEILSECkgHPVMLGLYSTYFfenkLT 107  nematode
XP_001640804   16 VDPNSNWELVGELGDGSFGKVYKAQHkt-eSSLSAAKIIIVndeNELEDFMVEIDILSECk-HKNLVGLFETFLhdgkLW 93   starlet sea a...
XP_001750610   14 ENPITIWQITGDLGAGTYGKVHLVRHrq-tGQKAAAKIAQIgasAQLSDFSTEVDILTSCr-HDNITNFIDGYFnkpdLW 91   Monosiga brev...
NP_995936      31 TDPAEFWEMVGELGDGAFGKVYKAQHke-qKRFAAAKMCQLedeENLSDHMVEIDILSEIk-HPNIVELYEAFSiddkLW 108  fruit fly
Feature 1         # ####  ##  #                                        ## #         ##            
2J7T_A         93 IMIEFCPGGAVDAIMLELDrgLTEPQIQVVCRQMLEALNFLHSKRIIHRDLKAGNVLMTleGDIRLADFGVSAKNLKTLQ 172  human
2J51_A        111 ILIEFCAGGAVDAVMLELErpLTESQIQVVCKQTLDALNYLHDNKIIHRDLKAGNILFTldGDIKLADFGVSAKNTRTIQ 190  human
AAN72832      106 IYLELCGGGALDSIMEALEkpLTEPQIRFVSREVLQGLEFLHEKLIIHRDMKAGNILLTlsNEVKLADFGVSAKLADEKQ 185  Schistosoma m...
NP_510290     108 MLLEFCGGGAVDNIIVELGhvLKEDQIRYIGYYVCDALKWLHSQNVIHRDLKAGNILLTqdGQVRLADFGVSAKLKSERE 187  nematode
XP_001640804   94 MMLEFCSGGALDDLMLELErgLNEPEIRAVTRQLFEGLQFLHNHKVIHRDLKAGNLLLAsdGNVKMADFGVSAKNKKTLQ 173  starlet sea a...
XP_001750610   92 IIIELCDGGSLGSLVDKTEagFDEGYIAPIMHQMLKALVFLHAHFVIHRDINCANTLITrhGTVKLADFGVSALGKSEDQ 171  Monosiga brev...
NP_995936     109 MLIEYCDGGALDSIMVELEkpLTEPQIAYVCKHMTEGLTFLHRNKVIHRDLKAGNVLLTmeGGVKLADFGVSAKNKHTMQ 188  fruit fly
Feature 1                                                                                         
2J7T_A        173 KRDSFIGTPYWMAPEVVMCETMKDTPYDYKADIWSLGITLIEMAQIEPPHHElnPMRVLLKIAKSDPPTLLTPskWSVEF 252  human
2J51_A        191 RRDSFIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGITLIEMAEIEPPHHElnPMRVLLKIAKSEPPTLAQPsrWSSNF 270  human
AAN72832      186 KRSTFIGTPYWMAPEVINCETFKDAPYNWKADIWSFGITLIELAQKRPPHNAtnPTRVLLKILKSDPPTLSRPhlWSSKF 265  Schistosoma m...
NP_510290     188 KRDTFIGTPYWMAPEVMACETFKDQPYDCISDIWSFGITLIEMAQGEPPHSDvsVMRVIIKVQKSEPPTLLQPshWTRSF 267  nematode
XP_001640804  174 KRSTFIGTPYWMAPEVVVTETYKDDPYDYKADIWSAGITLIELAQMVPPNHNmhPMRVLFKIPKSDPPTFDNPnkWSNDL 253  starlet sea a...
XP_001750610  172 RRHTFVGSPHWMAPEVVACENDSSNAYNSRADIWSLGITALELAQRRPPHADlhPIKVLFKILSGPSPTLDASrgFSSSF 251  Monosiga brev...
NP_995936     189 KHDTFIGTPYWMAPELVLCETFRDNPYDHKVDIWSLGITLIELAQMEPPNSEmsPMRVLLKIQKSEPPKLEQPsrWSKEF 268  fruit fly
Feature 1                                                     
2J7T_A        253 RDFLKIALDKNPETRPSAAQLLEHPFVssi--tsNKALRELVAE 294  human
2J51_A        271 KDFLKKCLEKNVDARWTTSQLLQHPFVtv---dsNKPIRELIAE 311  human
AAN72832      266 KTFLGRTLQKDPNQRPECRDLLLDPFVsdvtesdRKVIQILLCE 309  Schistosoma mansoni
NP_510290     268 SDILTRCLVKDPRNRPPAAEIFKHQWFqna-pskRKMIMDLLAE 310  nematode
XP_001640804  254 NDFLASCVVKNPDMRASATEMIKHPFIadf--tdNKALKDLYNE 295  starlet sea anemone
XP_001750610  252 HDFVASALVKKPTDRITAGALSKHPFVseq--gdKGKLKTLVQS 293  Monosiga brevicollis MX1
NP_995936     269 NDFLKKSLVKDPQVRPTTDVLMQHAFInrn--ldAKPIKDLLLE 310  fruit fly

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