Conserved Protein Domain Family
TM_PBP1_LivH_like

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cd06582: TM_PBP1_LivH_like 
Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of branched-chain amino acids (AAs). These types of transporters generally bind type 1 PBPs. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP, which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. E. coli LivH forms a heterodimer with another TM, LivM, to generate the transmembrane pore. LivM is not included in this subgroup. The LIV-1/LS transporter is comprised of two TMs (LivM and LivH), two ABCs (LivG and LivF), and one of two alternative PBPs, LivJ (LIV-BP) or LivK (LS-BP). In addition to transporting branched-chain AAs including leucine, isoleucine and valine, the E. coli LIV-1/LS transporter is involved in the uptake of the aromatic AA, phenylalanine.
Statistics
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PSSM-Id: 119324
View PSSM: cd06582
Aligned: 381 rows
Threshold Bit Score: 87.4864
Threshold Setting Gi: 196237274
Created: 9-Sep-2008
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
TM-ABC
Feature 1:TM-ABC transporter signature motif
Evidence:
  • Comment:a signature motif (the EAA motif) conserved in all TMs of ABC transporters.
  • Comment:a conserved hydrophilic segment, part of a loop which interacts with the cytoplasmic ATPase.
  • Citation:PMID 7934906

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                        
P0AEX7        15 GVTLGSTYALIAIGYTMVYgIIGMINFAHGEVYMIGSYvsfmiiaalmmmgidtGWLLVAAGFVGAIVIASAYGw----- 89   Escherichia coli
YP_428610    157 ALPVIALYGLLAASYTLIYaLGRTILLVFGELAMIGAMacfagv-----alfsgLGGLGTAGVVGGAVVFALLAsav--- 228  Rhodospirillum...
NP_105881     11 GLHSGALYALLAFGYVLINgILHRTNLAYGALFAFSGQamilsv----afgyqvLWLTLLVSVLFGVVAAFLYAali--- 83   Mesorhizobium ...
YP_001524458 151 ALPNMTAYAALAAAFTLIHgLTGRIILAMGEIAVAGGGamlava-----alapaTGAFTLAHLLLGLVAGTATGglw--- 222  Azorhizobium c...
NP_354143     11 AVPVAALYAVLAFGYAIAFsVTKRADVTYGAIFAFAGQtcll--------fadfGWNRLWLVLPATLALGAGAGlfgglw 82   Agrobacterium ...
YP_923343     11 GITSGAVYGLLAVAICLTYrVSKVINAAIGELMVLGALiass---------ligRGWPLAIAVVVGVGVVGLVAa----- 76   Nocardioides s...
YP_001507536   8 GLALGSIYAIASSALVITYvSTGVFNFAFGSMAFFVARfyyw--------lnseHGMSTVSAGLLSILVMAPLLg----- 74   Frankia sp. EA...
YP_001990564  12 GALIGAIYGLLAFPVSLLFvTTETVDLAVGAYAVLAAAv--------------aASFAAPLGIALGIAAAVAASl----- 72   Rhodopseudomon...
YP_001509010  11 GAVAGGLYAILAAGVVLTYqTSGIFNFAHGAVAFATAYlfvq--------lnvtAGVPVVPAAIISILVFAPLLg----- 77   Frankia sp. EA...
YP_001508331  27 GVPPGAVYALVALGFVLTYkTSGVFNLAFGAQAYVSAAmyfk--------arviWEWPTVPSVILAVFVMAPLIg----- 93   Frankia sp. EA...
Feature 1                                                                                        
P0AEX7        90 ---SIERVAYRPV---RNSKRl-IALISAIGMSIFlqnyvsltegsrdva-----------lpslfngqwvvghseNFSA 151  Escherichia coli
YP_428610    229 hgdALRRLVLQPA---AGRTPl-ALLVASFALAIVvqdyvrlsqdagdrl-----------lptlpgrthvlaragEFVV 293  Rhodospirillum...
NP_105881     84 -shVLSRSVFEPL---ADRSPnaIVVTTLGILIVLseasriaadthdlwl------------ppmlaqpivfaegaGFKA 147  Mesorhizobium ...
YP_001524458 223 -mlTFGRLVLRRMaerREASQa-VIIASIGLALVLreamtlaqsgsglwl------------prlvhtpiplagsaAFTA 288  Azorhizobium c...
NP_354143     83 aagLIGRAVMRPL---AKASPn-AVTVASIGVLIAltesarlaadtrqlw-----------lppllsqpvrfwiegGFAV 147  Agrobacterium ...
YP_923343     77 ---AFSGIILRPAi-kAKSTMs-QLLLVTFSLSILlqgvmlvaygrdi---------------hsapawiggdgmtIGGV 136  Nocardioides s...
YP_001507536  75 --vLLYGALFRFM---RGSSMl-VKIVSTIGLSVAlppisdlifgtdtit------------sapglaslndkpyhVFGT 136  Frankia sp. EA...
YP_001990564  73 ---VVAVLSLRTGastAKDPLa-IVLMTFGVSVFLesmvltgfgqnp------------------wirqpfetfwlAGPL 130  Rhodopseudomon...
YP_001509010  78 --lLLDRLVYRRL---AHAPLa-VKIVVPIGLLIAvpglclfissrlnlwfhldiagiedlflipglgptpkktwtLGGV 151  Frankia sp. EA...
YP_001508331  94 --lILERLIFRPL---RTAPAvaRLVVAAGLAVAIpylfdiladftavagv---------tpvgvvpdganvfydpFGVY 159  Frankia sp. EA...
Feature 1                                                ###################                     
P0AEX7       152 SITTMQAViWIVTFLAMLALTIFIRYSRMGRACRACAEDLKMASLLGINTDRVIALTFVIGAAMAAVAGVLLGQFYGvin 231  Escherichia coli
YP_428610    294 AVTDFQLVlVGGAGIVLGALVWGMGRGRFGRCWRAMAEDPQMATLCGVSKTRLWAICFALAATLAGLAGVVVLLRFGlan 373  Rhodospirillum...
NP_105881    148 TLTLIQVLdCAVVLAAVALATSAFARSSFGRRWRAVSDDPRAAALCGVDVRGVFRHAVLLGGFCAALAGVMASLYYGnvs 227  Mesorhizobium ...
YP_001524458 289 TVTPAMIGgALASGCGVAGVLALLRFSRFGRGWRAFRDDPLMASLCAVAPSRLLGATFLLAGALSGLAGASLVLVFGnvd 368  Azorhizobium c...
NP_354143    148 TLTPIQMLnTAVFCLLILTGSLYLGRSAFGRRWKAVSDDAFAASLLGVNASRIFLLSYCAAGLVAAIAGVLATFYYGtmd 227  Agrobacterium ...
YP_923343    137 VLQPQRLLiLAATLALGTGLVLYFSRSVHGRAMTATSQNPVGAALVGISVSRFRDVAFVGTAVIAALLGCMLIPITPf-v 215  Nocardioides s...
YP_001507536 137 VVTTDQLItYGFLVFTVVAGTAVLRLTDVGLRVRAMVDSEAMASLSGTNPGRVSLGVWAASSTLAGLAGILVAPTNGl-n 215  Frankia sp. EA...
YP_001990564 131 RISPQGAVnVGVGVALMAGLYVWLYRTAAGRDMRACAANAIAATLAGIPVRRITLMTHVIGGLLAGIAGVLILYTTGa-s 209  Rhodopseudomon...
YP_001509010 152 LLDSNQIAvFGAAVLTAVGLWVLLQRTRLGLQMRAVVDRRSLAALRGVDPDRTSAVSWMLGSFLAGLAGVLVAPIFT--- 228  Frankia sp. EA...
YP_001508331 160 AYSRNELVsMGVALVAMAGLVALFRFSAIGVRMRAVVESPKMTELNGIPADRVSALSWALSSLFAGVAGVLIAPRFNt-l 238  Frankia sp. EA...
Feature 1                                                                                        
P0AEX7       232 PYIGFMa--GMKAFTAAVLGGIgSIPGAMIGGLILGIAEAl-SSAYLst-------------eyKDVVSFa--LLILVL- 292  Escherichia coli
YP_428610    374 AFMGAMl--GFKALTAAVVGGIgRIQGAILGAVVIGGLETy-WAAYFdm-------------awRDVAVFa--LLAAAL- 434  Rhodospirillum...
NP_105881    228 FGSGLVy--GLKILFVTAVGGYlSPPRAALGAAAFGMAESl-WAGYFpi-------------ewRDAWMYl--FLVAMLi 289  Mesorhizobium ...
YP_001524458 369 AALGLPl--TLKTLAGAILGGVgSVGGAAAGGLLVGALEGgwSSVWDia--------------wRDVAIYg--LLILGL- 429  Azorhizobium c...
NP_354143    228 FGAGLVf--GLKVVLISAAGGYaSPLICGLGAAAIGFAETf-WVGYGpv-------------awRDAAVLa--LLVGWLi 289  Agrobacterium ...
YP_923343    216 YNAGLPl--ALVGMVGATLARFvNIGVAMAAGIVIGVLEQm-IARYVsa-------------dlQTSLVY---IVLTVLm 276  Nocardioides s...
YP_001507536 216 TGGMTSl--MCAAIAAVVAARLrSLPGAVAAALAMGVITDv-IQKYLptnst-------ltaaiVPSIPFa--FMLVFLv 283  Frankia sp. EA...
YP_001990564 210 YSSSLGl--TISGFGAAAILGLhSPLRSFFGGVAIGMAEAl-AVGYLpv-------------glGAAAPLl--FILLVLi 271  Rhodopseudomon...
YP_001509010 229 LNTPVFttvVLISTPAVVFARFrSMPLALAGGLLIGVLQNl-IVGYAdfaqn--------isgfSTSVPF---ILLLGLl 296  Frankia sp. EA...
YP_001508331 239 AAADFFs-lMVVAIAAAAVGRLtSLPKAMAGGLLLGIIIAq-LNTFLprwsddhawvstiqdnlTPSVPFvvlFGVVVLv 316  Frankia sp. EA...
Feature 1                                     
P0AEX7       293 ---------------------LVMPTGIL 300  Escherichia coli
YP_428610    435 ---------------------VLRPQGLV 442  Rhodospirillum rubrum ATCC 11170
NP_105881    290 l------------------igAGRDTGKV 300  Mesorhizobium loti MAFF303099
YP_001524458 430 ---------------------VARPEGLF 437  Azorhizobium caulinodans ORS 571
NP_354143    290 ---------------------VMRSRVEA 297  Agrobacterium tumefaciens str. C58
YP_923343    277 ---------------------LAVPSAFA 284  Nocardioides sp. JS614
YP_001507536 284 fyvvrsgsvdenagaggpldaAIRPASQD 312  Frankia sp. EAN1pec
YP_001990564 272 tg----------------kanIGHAGGRA 284  Rhodopseudomonas palustris TIE-1
YP_001509010 297 fv-----------------faVDRSRRAG 308  Frankia sp. EAN1pec
YP_001508331 317 p-------------------sIRRSRETG 326  Frankia sp. EAN1pec

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