Conserved Protein Domain Family
TM_PBP1_LivM_like

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cd06581: TM_PBP1_LivM_like 
Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of branched-chain amino acids (AAs). These types of transporters generally bind type 1 PBPs. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP, which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. E. coli LivM forms a heterodimer with another TM, LivH, to generate the transmembrane pore. LivH is not included in this subgroup. The LIV-1/LS transporter is comprised of two TMs (LivM and LivH), two ABCs (LivG and LivF), and one of two alternative PBPs, LivJ (LIV-BP) or LivK (LS-BP). In addition to transporting branched-chain AAs including leucine, isoleucine and valine, the E. coli LIV-1/LS transporter is involved in the uptake of the aromatic AA, phenylalanine.
Statistics
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PSSM-Id: 119323
View PSSM: cd06581
Aligned: 387 rows
Threshold Bit Score: 84.4177
Threshold Setting Gi: 171185691
Created: 9-Sep-2008
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
TM-ABC
Feature 1:TM-ABC transporter signature motif
Evidence:
  • Comment:a signature motif (the EAA motif) conserved in all TMs of ABC transporters.
  • Comment:a conserved hydrophilic segment, part of a loop which interacts with the cytoplasmic ATPase.
  • Citation:PMID 7934906

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                        
P22729       118 TMIYIILGLGLNVVVGLSGLLVLGYGGFYAIGAYtfalln----hyyglgFWTCLPIAGLMAAAAGFLLGf---PVLRLR 190 Escherichia coli
NP_884566    332 ILIAALFAVSLHFMMGPGGMHSFGHAAYFGLGAYgaalll----kaaslpMEAALAFAPLVAALGALIFGw---FCVRLS 404 Bordetella para...
NP_770466    339 IAIFVIFAVSLHFLMSVGGLASFGHAAYFGLGAYgiafla----kmaglpMIVCLLLGPLLGCMGAAVFGf---FAVQLS 411 Bradyrhizobium ...
YP_345240     50 TLIQAVFALSWNLLFGFTGLASFGHAGFFAIGAYftgaalr---ydfhlpFLAVLAVAGLLGALVALAIGv--vALKRLT 124 Rhodobacter sph...
NP_766835     66 VIILALFALSFDLVWGYAGIMSFGQALFFGSAGYgvallar---dlditnIFLVLPAGTIIGLTFALLLGg--fLLLGRH 140 Bradyrhizobium ...
YP_556464     36 VLILSLLALSFDLVWGYAGILSFGQALFFGGGGYvaavlar---dygvnaAIVALPAAILAGALLSAVVAgvvvLGKSAT 112 Burkholderia xe...
YP_981851    344 ALILMIFGISLQSMMALGGLVSFGHAAFFALGAYgaalsh----slwgatLPVALATGCGAALAVAGVFGa---AVVRSS 416 Polaromonas nap...
EDY79238      36 FMVWTFMAMGLGIVWGYCGVLSFGQTAFFGLAGYaygvvsin-lgaafglTWLALVLSVTIGGAFALLIGyf-mFYGRIK 113 Octadecabacter ...
YP_001889470  42 CLLWAFSALGLAAMWGYGGILSFGQTAFFGLSGYtygiftln-ygdtwfeSWLGLGAGIVVSIVAAGLIGym-vFYGRIK 119 Burkholderia ph...
EDY78111      39 WIIFGLLGLSLDVIWGRGGLLSLAQTAFYGLGGYfgaviainmapsfgmtLVWALPAAAVFGALIAAALGyi-iFYSRMG 117 Octadecabacter ...
Feature 1                                                                                        
P22729       191 GDYLAIVTL---GFGEIVRILLlnn--------teITGGPNGISQIPkptlfglefsrtareggwdtfsnffglkydpsd 259 Escherichia coli
NP_884566    405 GVYLAMLTL---AFSQIVWSVVfqw--------ddFTGGSNGMIGVWpaewlsg-------------------------- 447 Bordetella para...
NP_770466    412 GVYFAMLTL---AFAQIVWSIAfqw--------vsVTGGDNGILGVWpekwaas-------------------------- 454 Bradyrhizobium ...
YP_345240    125 GIFLAVLTV---ALTEAMAKIIgf---------spALGEQDGLGNIPrpviemglfqi-------------------dlt 173 Rhodobacter sph...
NP_766835    141 PSSVIFVSLgtlTGSYAADRLArg---------wyYLGGQNGIPSIApmtlggyef-----------------------s 188 Bradyrhizobium ...
YP_556464    113 QIFIALGTM---TASYAAYRLAis---------wyYLGGQNGISSLPllktgsyef-----------------------d 157 Burkholderia xe...
YP_981851    417 GVYLAMLSL---ALAQVVWAGAaqw--------vsLTGGDNGLIGLAlvtddgr-------------------------- 459 Polaromonas nap...
EDY79238     114 GVFIGIVTL---SVTLVLETFMaqtagpnwrigdaRLNGFNGMSGMPpltvpwpggdi-------------------vly 171 Octadecabacter ...
YP_001889470 120 GVFIGIVTL---SVTLVLETFMsqtagpqwaigeaRLNGYNGMGGMPqltipwpggpl--------------------tl 176 Burkholderia ph...
EDY78111     118 ELQSTILSY---TFTLLLWSVTqtfkl---dvgeaTIGGDNGLSNIPgiilgfgaeag--------------------kl 171 Octadecabacter ...
Feature 1                                               ###################                      
P22729       260 rviflylvALLLVVLSLFVINRLLRMPLGRAWEALREDeIACRSLGLSPRRIKLTAFTISAAFAGFAGTLFAARQGFVSP 339 Escherichia coli
NP_884566    448 --tayyylALAVVAAAVLGLRRVLFSPFGYAMRAGRDSsLRADAIGIDVKRVQWAAFVVAGAFGGLAGALYAFSKGSISP 525 Bordetella para...
NP_770466    455 -pshfywlALGVAALVTVALRAMVFSPFGYALRATRDSlLRSEAIGINAKRIQWTAFVIAGTTAGIGGALFAYLKGSVFP 533 Bradyrhizobium ...
YP_345240    174 hgddyyrfLVVATVLIVAALWWVVHSRLGRTFRAIREDaDRARFVGIDVARYRVISFMISGGTAALAGALSAPLTRIVTL 253 Rhodobacter sph...
NP_766835    189 egpafyylVLGILVVVYLLCRFLVRSQFGLALAGLRENeQRIAFFGYKAQHLKAIIFTIGGGVAGLAGSLYAFHEGFVWP 268 Bradyrhizobium ...
YP_556464    158 egprfyylALALLIVIYAVSRFLVRSQLGLALTGIRENvRRMVFLGYRVNVFKAAVFVFSGAIAGLAGGLTAFHEGFIGP 237 Burkholderia xe...
YP_981851    460 --pvfyalLVALALIAVFALRFLSRSVMGAALQAVRDApLRAAASGLSVGWLKYRVFVESAVLAGLAGGLFAAHKGAVFP 537 Polaromonas nap...
EDY79238     172 sgtalyfvLLVMVVVCYLGLRMLLNAPFGNVLVAIRENpERAEMLGYDIRLYQTLAFGLGGALAALSGTLYTAWGQYITP 251 Octadecabacter ...
YP_001889470 177 envsfyylVLLLLIAVYAIMRKLLDGTFGLTLIAIRENpQRAEMLGVDIRRHQLMVFVLGCTLGGLSGALYTIWGSYITP 256 Burkholderia ph...
EDY78111     172 kpngafatVVVVSAAVYFFTHWLMRSNFGKVVDCIRIDiEKTELLGYDIRKIQVLNFAYSGAIAGIAGALFALWANYLNP 251 Octadecabacter ...
Feature 1                                                                              
P22729       340 eSFTFAESAFVLAIVVLGGMgSQFAVILAAILLVVSRELMRDFne--ySMLMLGGLMVLMMIWRPQGLLP 407 Escherichia coli
NP_884566    526 dTMAVSKSVDGLVMVLLGGIqTLIGPVVGATAFNVLQDYIMRAte--yWRALFGGVILLLVLVFPQGIAG 593 Bordetella parapertussis ...
NP_770466    534 dNLGISLSVDALVMVLLGGVeTVSGAVIGAIVYKALNIWLVSQtd--lSKLVLGGFIVLIVVVFPKGIVG 601 Bradyrhizobium japonicum ...
YP_345240    254 dQVNWLASTQPILNSLLGGFtSFWGPIVGSAAFSTINYFTRGFpg--lSEIMVGGILVVVILVAPTGILG 321 Rhodobacter sphaeroides 2...
NP_766835    269 nMVGVVVSTQVVLYVLFGGSgTLIGAVIGAIIVEGVSFWLSDNyr-diWPIILGLLLLLVILFRPLGLIS 337 Bradyrhizobium japonicum ...
YP_556464    238 gSLGTVLSTQAVLYSLLGGSgTLIGAVFGAVIIETLGFGLSDRlp-elWPVLLGIILLLLIIYRPQGLIS 306 Burkholderia xenovorans L...
YP_981851    538 sLAAVSTSVDALLVVLLGGVhQLWGAVVGSLVLTYASAELGREvt--yWRGLLGVFIMLIMVASPSGLLG 605 Polaromonas naphthalenivo...
EDY79238     252 sSMGLTAAALPIVWVAVGGRrDITATLLGSILVIAGFQTLTIYgs-qyALIVMGALLVFTVLVTPDGLIS 320 Octadecabacter antarcticu...
YP_001889470 257 sTMGLTAAAMPVIWVATSGRkSIGGTIIGTAFLVWLSQNLAVYgs-qyALILLGAILLIVVLAAPEGLLP 325 Burkholderia phytofirmans...
EDY78111     252 sIFSVQEALLIPIYVLVGGLgTLAGPFLGAIVIGALSFWLGGGaaggqTTLILGAILILLVLFLQNGFLG 321 Octadecabacter antarcticu...

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