Conserved Protein Domain Family
TM_PBP1_transp_TpRbsC_like

?
cd06580: TM_PBP1_transp_TpRbsC_like 
Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters, which are mainly involved in the uptake of branched-chain amino acids (AAs) or in the uptake of monosaccharides including ribose, galactose, and arabinose, and which generally bind type 1 PBPs. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP, which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction.
Statistics
?
PSSM-Id: 119322
View PSSM: cd06580
Aligned: 160 rows
Threshold Bit Score: 85.1834
Threshold Setting Gi: 152966087
Created: 9-Sep-2008
Updated: 2-Oct-2020
Structure
?
Aligned Rows:
 
TM-ABC
Feature 1:TM-ABC transporter signature motif
Evidence:
  • Comment:a signature motif (the EAA motif) conserved in all TMs of ABC transporters.
  • Comment:a conserved hydrophilic segment, part of a loop which interacts with the cytoplasmic ATPase.
  • Citation:PMID 7934906

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                        
O83343        15 STPILITALGGLFSERSGVINIALEGLMMFGAFstatvtvl--cepytiaaPWIALGVGMAVAASVALFYAYLSVRLCSD 92  Treponema pallidum
YP_476570     68 LAPLVLCCCGLVFTFVAGLYNLGIEGQMVVGAIaatflvrleagwlppplaITLALLAGILGGAGWGLLAGILNVWGRVN 147 Synechococcus s...
YP_001637437  60 AAPLLLCAVGLSITFAGGLYNLGVEGQMIMGAIaamvplrlw-pdvsppllWLLAALCGMAGGAFWAGLIGLLRRYAGVS 138 Chloroflexus au...
Q988C0        21 AIPLLLAGLGEQMSEKAGVLNIGIEGMMLAGAYlgfvga-------fysgsLWLGFLTGAAGGVAVALIMALLCVCIGLN 93  Mesorhizobium loti
YP_001012317  66 FVPIGLSAAGLALAYRAGFITIGSEGQVILGLTvthgllayvlwdapglagLVAALVLAAIVGGACGLLVGAMRAYLGTN 145 Hyperthermus bu...
NP_146935      9 LIPLSLAALGEAVLERTGRVNLGVDGLMAVGAAvgalag-------vetgsLLAGLAAGALAGGVGSLSYIILTDRLGVN 81  Aeropyrum perni...
YP_001012316  14 AAIVAVAAYGELLMERAGMLNLGLEGLVYFSSAaaaaaa-------aatgsLSAGFAVGALAGIALILVYYVAAIVFRAN 86  Hyperthermus bu...
YP_001602934  13 TTPILLAALGGAINRQGGTVNVGLDSFILAGALagevas-------avtgsSLGGVAGAAIAGGGTAALMAAVIRFARTD 85  Gluconacetobact...
NP_146934     52 AAILVAAASGLVLSYRAGLITIGVEAQVTASAVaalyal------ayaglgLPGALTLAAIVSLAIGIVIAALRVYLDVN 125 Aeropyrum perni...
YP_001040155  15 FLAYYLAALGHAIVEKSGVLNLAIDGVFVLSVStafata------vythnnIGAALIVSMIIALIFGGLMAFLVTKFPIS 88  Staphylothermus...
Feature 1                                                                                        
O83343        93 QIIAGTAINLCATGMTVFFaqvifgqqgtqaysrglvktsygffsripvlgpmvfthtyptVYLGFVLVALAWYVLYRTP 172 Treponema pallidum
YP_476570    148 EIFAGLGLNFVAQGWVLYLifgpwkrpgvasmsgtevl-----dprlwlptwgrseaspvaLLLALLALALTVLVVGNTR 222 Synechococcus s...
YP_001637437 139 EIFAGLGMNFLASGIAMYMvlgpwrrqtsaslsgtdll-----prelwwptidrlrlapaaPVIALLALAVVWWALTKTR 213 Chloroflexus au...
Q988C0        94 QIVIGIALTLGLEGLTALLhhfqfsrsyprlpaaeatvi---pllsdipvvgpalfkhhliVYLAVALVFGMGYLYRRTQ 170 Mesorhizobium loti
YP_001012317 146 ETLISLMLNYVVVAIVNYLvsgpwkagrftmtv---------------vlpekfwvsgataAAVAAAAIVVLDLVHRFTR 210 Hyperthermus bu...
NP_146935     82 MIVAGLLVFFAGIGLGDLVgskiagrpg------------------------pvltslyttAATIGIAAVALHLILYNTV 137 Aeropyrum perni...
YP_001012316  87 QAVTGLAIVFLGIGLGDLVgsnaagtplps---------------------lslgvknyasLALLVLPAVVLYALLYRTW 145 Hyperthermus bu...
YP_001602934  86 QIVTGLGFDMSAQAVCRLVvklafgvtgllslpaar---------rlpvvaipelgtldalTLLSWSLVPACAWFLRHHR 156 Gluconacetobact...
NP_146934    126 EILSSLMINYIVLYMVNGLvsgplregaftkt-----------------rsieafvgpleaGLAAVSMAALSWILLERTS 188 Aeropyrum perni...
YP_001040155  89 HGATGLSLMFLGYGLASLIglparnlqgrtgiei-------------gytlditnpmwigvYVITILLGIAFLYIINKTK 155 Staphylothermus...
Feature 1                    ###################                                                 
O83343       173 FGVHVRATGDQpYAVDGAGLSVFRLRSAAVVISGLCAGLGGGVLILTQDiqy-tvYSTHG---TGFIALAALISGRWHPF 248 Treponema pallidum
YP_476570    223 FGLQLRAVGKNpVAAFRLGIPATRRLLMAFACCGGLAGLAGALQVLALFhrl-ipNISSN---LGFLALLVVMLAGFNPL 298 Synechococcus s...
YP_001637437 214 WGLEVRAVGLNpAAAGRLGVAAARRMLETLAACGALAGLAGMVQVVAVHhal-ipNISSG---IGLLGLLVALLARADPR 289 Chloroflexus au...
Q988C0       171 LGLNLQAAGDKpAALDVAGIDVIRTRTIAVLTTGALAGLGGAYLANVGAglf-ipFITNG---AGFLGIVLAMLARGRPV 246 Mesorhizobium loti
YP_001012317 211 LGVAIDAVGAArKAAETYGVDPRRTILAAAALSGAAAGLGGALYIVSIHtp--ltTIGKGglgYGYMGVLAAWLAGLRPL 288 Hyperthermus bu...
NP_146935    138 TGTALRVVGENpAAAKERGVPVWRLRLSAALVQGLSAGLAGYIMVAGLSygkwysGVTAG---LGWVALGIVILGYWTPI 214 Aeropyrum perni...
YP_001012316 146 VGYAVRSLGEDvEAARFLGVNVAVYRLAVALTAGALAGIAGAFIFLSRPgtw-saGVALG---WGWLALGSVILGYWHPV 221 Hyperthermus bu...
YP_001602934 157 LGLRLRAAGESpGAATALGFDPKRLQAAATIAAGVLAGLAGADLSLGIVgaf-stNISNG---RGFMALAAFYIGRARPF 232 Gluconacetobact...
NP_146934    189 LGISLRASGPApRAADIYTIGRARAMLLSSLPQSLAAAAAGLILLGGIQtvftalKQPQG---YGYAAVLVSWMAELSPT 265 Aeropyrum perni...
YP_001040155 156 LGASIRAAGEDpAAAEALGANVLSVRLIAGIIGFALIGLGGAIFEISYTqvw-seGQGLG---HGWLAFAISLSAGRHPL 231 Staphylothermus...
Feature 1                                                                  
O83343       249 GVLVTSVLFGFSQI-----LNVYAtsvellkhlpielFSALPYa--------LTVVVL 293 Treponema pallidum
YP_476570    299 LILPIAFFFSSLNI-----GSLQLplslq---lesslAGVIQGs--------LVLFVL 340 Synechococcus sp. JA-2-3B'a(2-13)
YP_001637437 290 WLLPVTIAFAAFTV-----GSIQLpltlg---idsaiAGVLQGa--------LVLFAL 331 Chloroflexus aurantiacus J-10-fl
Q988C0       247 WVLLGALLFGVCLS-----LTTAMqvagin--iptdvIQMLPFl--------AVMIML 289 Mesorhizobium loti
YP_001012317 289 GALAAGMLLAVLYNm----VSMLQ-------------LQGIPAslvyafeaiLVLSVL 329 Hyperthermus butylicus DSM 5456
NP_146935    215 GVLIASTAVSTVFS-----MRTQIaaatg----ipplADAIPYi--------LVLILL 255 Aeropyrum pernix K1
YP_001012316 222 GVAAAAYLIGLANT-----LIMVLeglgv----pavvAENTPYi--------MVVVAL 262 Hyperthermus butylicus DSM 5456
YP_001602934 233 STAAACLMLGLLTE-----AAIHAqadgl----ptalAQAAPYl--------AVICVL 273 Gluconacetobacter diazotrophicus PAl 5
NP_146934    266 TLIPVSLFFAWIAGagfilQAYGMps---------slVLLLQSia------lTVYMVA 308 Aeropyrum pernix K1
YP_001040155 232 LILISAGVFAGLVN-----YMTAIqaays---lppdlAKMLPFvaa---ilaMVIFMA 278 Staphylothermus marinus F1

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap