Conserved Protein Domain Family
TM_PBP1_transp_AraH_like

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cd06579: TM_PBP1_transp_AraH_like 
Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group also contains E. coli RbsC, AlsC, and MglC, which are TMs of other monosaccharide transporters, the ribose transporter, the D-allose transporter and the galactose transporter, respectively. The D-allose transporter may also be involved in low affinity ribose transport. These transporters generally bind type 1 PBPs. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP, which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. Proteins in this subgroup have a single TM which homodimerizes to generate the transmembrane pore.
Statistics
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PSSM-Id: 119321
View PSSM: cd06579
Aligned: 305 rows
Threshold Bit Score: 119.821
Threshold Setting Gi: 115358081
Created: 9-Sep-2008
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
TM-ABC
Feature 1:TM-ABC transporter signature motif
Evidence:
  • Comment:a signature motif (the EAA motif) conserved in all TMs of ABC transporters.
  • Comment:a conserved hydrophilic segment, part of a loop which interacts with the cytoplasmic ATPase.
  • Citation:PMID 7934906

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                       
P0AGI1       53 TSVNAIMAVGMTLVILTSGIDLSVGSLLALTGAVaasiv-gievnALVAVAAALALGAAIGAVTGvIVAKGRVQAFIATL 131 Escherichia coli...
YP_707642    73 EAVLILVALGAMLPLIVGQYDLSVGANMGMASIAvamatselgfsTGAGIAVAIVLSTLLGFVNGfLVAKIGISSFVATL 152 Rhodococcus sp. ...
YP_921831    88 QAVIGVISLGLLLPLLCQEFDLSVGNIAGLAAIVvaayv-ssegnVLAAVVLALTIGLAIGAVNAlIVTRLHVNGVIATL 166 Nocardioides sp....
YP_712744    49 QSILGILAIATVIPLVAGQIDLSVGPNAGLTSVLcaglmsksgwpLFPAILAAIVVGLVIGTINAiLVASVGINSIIATL 128 Frankia alni ACN14a
YP_921893    73 QATAAMLAMGVTLVLIIGEFDLSVAAVMGLSASLiaylttehgvsVPLACLVALALAAIVGLVNAaLVVGAGLNSFIVTL 152 Nocardioides sp....
ZP_01155968  63 AAFLTLAAQGQALVIMARGIDLSVPAIVTLSSTVllavsggtegnSLLAILVALAAAMLVGAVNGfFIAVLRMNALIVTL 142 Oceanicola granu...
ZP_01443598  64 AAILAITAVGMTVVIQQRGLDMSLPGTMTIAGLLfakig-fmtgsTLLAVPLTLLIALGIGIVNGlLVAKVNITPIVVTL 142 Roseovarius sp. ...
YP_921333    65 QAVPLVLTLCLVLPLVCGDYDMSVASVATLTAMVigilnvnhgwsIGAAILAGLLAALLAGLVNGaVIVIFGVDSLIVTL 144 Nocardioides sp....
YP_708979    75 QATVLLLAVAITIPLRSGDMDLSVAAVMVMCATVvgaly-sngvsALLSCVIAVGVGLVIGVLNAvLIVVAGLESIIVTL 153 Rhodococcus sp. ...
EDY91344     47 EAVLVIVTLGLIIPLTAGDFDLSIAQVLTLVSMStalmdarmdvpLLIVIPIALAIGALIGFINGaITLYFRVNSLIVTL 126 Octadecabacter a...
Feature 1                                                                                  #####
P0AGI1      132 VMMLLLRGVTMVYTNGspvntgftenadlfgwfgigrplgvptpVWIMGIVFLAAWYMLHHTRLGRYIYALGGNEAATRL 211 Escherichia coli...
YP_707642   153 AVSSLLSGIVIWSTDGtvivdnipsaltd---igrssilyipipFLLVIVIALVMGYVLRMTPTGRYLYAVGGSSEASRL 229 Rhodococcus sp. ...
YP_921831   167 GMSTILGGIVLQRTGGlapasdipqsltn---fgtglvagvpiiFITLLVIAGITYFVLNHTSLGRQIYAVGSNMEAAKL 243 Nocardioides sp....
YP_712744   129 GMSSVIGAAVLAYSGGvsittgvspgllr---lgpgkwlsvptlFYFLLGIALVAWYLLEKTPTGKNLYAIGSNPRAALL 205 Frankia alni ACN14a
YP_921893   153 AVGTLVQGLAIGVAGSvtigglptslty----pfqsrfldvqaaFFFMLAVAFVLYLVVGRMPIGRSMFFTGNARAAAEL 228 Nocardioides sp....
ZP_01155968 143 AVGAIVTGLTLSFRQAlpaeanvpaalad---fgggrtlgisnpFWIALVVTVLATLVLRKTVIGRKFEAVGANPAAARA 219 Oceanicola granu...
ZP_01443598 143 ATNAILMGAVRAVSGGspmtapaelaef-----shsklfgvpmtLVLALLFILVISVVTKRSIAGRRFVAVGQNPAAATA 217 Roseovarius sp. ...
YP_921333   145 GTGTVIQGLVLWISDSttvsgistslvdl---vigyklfsvpaaFYYGLALCVVLWYLLQHTALGMRMLFIGRGRDVARL 221 Nocardioides sp....
YP_708979   154 GMYTLVAGLTSFVSGGnlvttipkslkd----fattpfltlpaiVWIGWLVALVVWFVFEFTPMGRYLLFVGGNRAAATL 229 Rhodococcus sp. ...
EDY91344    127 GVGTFLHGVTLWIGNSqtisgvspmlmew---viiqrvfgipiaFYYAMMLAVLIWYMLGYTAFGQQLLFTGRGREVGRL 203 Octadecabacter a...
Feature 1       ##############                                                                  
P0AGI1      212 SGINVNKIKIIVYSLCGLLASLAGIIEVARLSsaqpTAGTGyELDAIAAVVLGGTsLAGGKGRIVGTLIGALILGFLNNG 291 Escherichia coli...
YP_707642   230 SGLSVDRLTITTFAASGFLCGIGGVLLVSKLGsanpTTGPEfLLPAFAACFLGATsIRPGTFNVTGTILAVLVLAVGSTG 309 Rhodococcus sp. ...
YP_921831   244 VGLRTDGLRAVTFAAGGLLCGLGGLLYVSRAGgaspNVGMTfTLPAFAAAFLSAAsVRPGRFNVWGTIIAVYFLAVLNNG 323 Nocardioides sp....
YP_712744   206 VGIGVSRQTFGSLVLAGGIAGGAGVLLVAAVGagspQLGSNyTLPAIAAAFLGATsIQPGRYNVWGTITAVFFLAISVNG 285 Frankia alni ACN14a
YP_921893   229 AGVRTARVRVGVMMTAGLLAGAAGVMFVGQTGaaspSIADPfLLPAYAAGFLGATaFTPGRFNVWGSVWAVYLLAVGTTG 308 Nocardioides sp....
ZP_01155968 220 AGIETMRFQAGAYISAALLYGIMAVLISGFIRnptlEVGAPyLLAPIAAAVLGATsINGGIGSMIAILGAALFLTQLGQQ 299 Oceanicola granu...
ZP_01443598 218 AGIPILRYQVATYAVAALCFAVAGMLFTGFIGsasqTAGIDyLLPAIAAVVVGGTpFSGGRGSVIASGAAALFMALLGQM 297 Roseovarius sp. ...
YP_921333   222 SGIAVPRVRMGALVASAGLAGVAGTLYAGTTGsadpSSGTSfLLPAFAAVFLGATtVIPGRFNAWGAFIAVYFLATGITG 301 Nocardioides sp....
YP_708979   230 AGLRVSRIRITALIAAAVISAIAGVLFAGSIGsvdpSSGHSyLLAPATAAFLGTTmIHMGRFNIIGTLIGLYLLAFGITG 309 Rhodococcus sp. ...
EDY91344    204 TGVAVGRVRLTAFVLSGIMGAIAGILYTGTTGsanpSSGTFlLLPAFAAAFLGATcIKPGRFNPWGAVIAVYFLVTGING 283 Octadecabacter a...
Feature 1                                 
P0AGI1      292 LNLLGvssyYQMIVKAvVILLAVLVD 317 Escherichia coli O157:H7 str. TW14588
YP_707642   310 LQLIGvpfyIEPIFAGvVLLIAALVT 335 Rhodococcus sp. RHA1
YP_921831   324 LSLAGvdpyVNDYVNGgALIAGVALA 349 Nocardioides sp. JS614
YP_712744   286 LTLWGaapwVSELFDGaALIVGVGLG 311 Frankia alni ACN14a
YP_921893   309 FQFLGldnwVINVFNGgVLVLAVGLS 334 Nocardioides sp. JS614
ZP_01155968 300 LRLFGletsYQMIIQGiAIAIGMWLS 325 Oceanicola granulosus HTCC2516
ZP_01443598 298 VLAFGaetsVQLLVQAgAIIVAVSVR 323 Roseovarius sp. HTCC2601
YP_921333   302 LQLLGaesfVQQLFYGgALVIAVSLA 327 Nocardioides sp. JS614
YP_708979   310 LQLLGvqgwVSDVFNGaALIVAITFA 335 Rhodococcus sp. RHA1
EDY91344    284 LSVLGfrtfVQDLFYGgALVLALMVS 309 Octadecabacter antarcticus 238

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